3-氨基-6-氯哒嗪 → 6-(4-Benzylpiperazin-1-yl)pyridazin-3-ylamine

HRID 80717

反应方程式

HRID 80717 反应方程式
[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:14][C:15]1[N:16]=[N:17][C:18](Cl)=[CH:19][CH:20]=1>C(=O)(O)[O-].[Na+]>[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([C:18]2[N:17]=[N:16][C:15]([NH2:14])=[CH:20][CH:19]=2)[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参与物

4

反应物 2

HCID 216433-氨基-6-氯哒嗪HCID 759941-苄基哌嗪

产物 1

HCID 593677126-(4-Benzylpiperazin-1-yl)pyridazin-3-ylamine收率 82.2%

试剂、催化剂与溶剂 1

HCID 516892碳酸氢钠溶剂

实验过程

48.9 g (278 mmol) of 1-benzylpiperazine and 12.0 g (92.6 mmol) of 3-amino-6-chloropyridazine are heated at 160° C. for 1 hour. The brown oil obtained is poured into 500 mL of aqueous sodium bicarbonate solution and the product is extracted with dichloromethane. The organic phase is dried and then concentrated under reduced pressure. The oil obtained is triturated in diethyl ether, and 20.5 g of a solid are isolated after filtering off and drying.

后处理

  1. customThe brown oil obtained
  2. extractionthe product is extracted with dichloromethane
  3. customThe organic phase is dried
  4. concentrationconcentrated under reduced pressure
  5. customThe oil obtained
  6. customis triturated in diethyl ether

来源与证据

ORD记录
ord-365f660cdcd04b8c95be9d01d77f0cb0
来源数据集
uspto-grants-2014_09
专利号
US08846676B2

关联笔记

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