3-氨基-6-氯哒嗪 → 6-Chloro-2-phenyl-3-pyrid-4-ylimidazo[1,2-b]pyridazine

HRID 80735

反应方程式

HRID 80735 反应方程式
Br[CH:2]([C:11]1[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=1)[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[Cl:17][C:18]1[N:23]=[N:22][C:21]([NH2:24])=[CH:20][CH:19]=1>C(O)C>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]2[N:22]([C:2]([C:11]3[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=3)=[C:3]([C:5]3[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:24]=2)[N:23]=1

参与物

4

反应物 2

HCID 216433-氨基-6-氯哒嗪HCID 134660102-Bromo-1-phenyl-2-pyrid-4-ylethanone

产物 1

HCID 594069546-Chloro-2-phenyl-3-pyrid-4-ylimidazo[1,2-b]pyridazine

试剂、催化剂与溶剂 1

HCID 702乙醇溶剂

实验过程

A mixture of 13 g (36.5 mmol) of 2-bromo-1-phenyl-2-pyrid-4-ylethanone (CAS No.: 741633-76-1) and 18.9 g (146 mmol) of 6-chloropyridazin-3-ylamine in 200 mL of ethanol is maintained at 90° C. for 5 hours 30 minutes. After cooling, the solvent is evaporated off under reduced pressure, the medium is taken up in 50 mL of water and the product is extracted with ethyl acetate. The organic phases are dried over magnesium sulfate and then concentrated under reduced pressure.

后处理

  1. temperatureAfter cooling
  2. customthe solvent is evaporated off under reduced pressure
  3. extractionthe product is extracted with ethyl acetate
  4. dry with materialThe organic phases are dried over magnesium sulfate
  5. concentrationconcentrated under reduced pressure

来源与证据

ORD记录
ord-3197f8470dfc43b6a117c10cf499bc10
来源数据集
uspto-grants-2014_09
专利号
US08846676B2

关联笔记

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