2-氨基-5-碘吡啶 → 5-苯氧基吡啶-2-胺

HRID 839635

反应方程式

HRID 839635 反应方程式
[C:1]1([O-:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[K+].[NH2:9][C:10]1[CH:15]=[CH:14][C:13](I)=[CH:12][N:11]=1>CC(N(C)C)=O>[NH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:12][N:11]=1

参与物

4

反应物 2

HCID 885792-氨基-5-碘吡啶HCID 23670670苯酚钾

产物 1

HCID 221794545-苯氧基吡啶-2-胺

试剂、催化剂与溶剂 1

HCID 31374N,N-二甲基乙酰胺溶剂

实验过程

3.3 G. of potassium phenolate, 5.47 g. of 2-amino 5-iodopyridine and 1.78 g. of cuprous oxide in 150 ml. of dimethylacetamide are heated at reflux under a nitrogen atmosphere for 24 hours. The solvent is removed in vacuo and the residue is extracted with chloroform. Chromatography of the methylene chloride soluble portion with silica gel and elution with ethyl acetate yields 2-amino-5-phenoxy pyridine m.p. 67°-69° C.

后处理

  1. temperatureat reflux under a nitrogen atmosphere for 24 hours
  2. customThe solvent is removed in vacuo
  3. extractionthe residue is extracted with chloroform
  4. washChromatography of the methylene chloride soluble portion with silica gel and elution with ethyl acetate

来源与证据

ORD记录
ord-eaa44ef71d95469786d79e2ca79f7d0d
来源数据集
uspto-grants-1978_06
专利号
US04096264

关联笔记

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