聚脲 → N-(2-propylpentanoyl)urea

HRID 83977

反应方程式

HRID 83977 反应方程式
[C:1](Cl)(=[O:9])[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5].S(Cl)(Cl)=O.C(O)(=O)C(CCC)CCC.[NH2:25][C:26]([NH2:28])=[O:27]>C(#N)C>[CH2:3]([CH:2]([CH2:6][CH2:7][CH3:8])[C:1]([NH:25][C:26]([NH2:28])=[O:27])=[O:9])[CH2:4][CH3:5]

参与物

6

反应物 4

HCID 1176聚脲HCID 3121丙戊酸HCID 24386氯化亚砜HCID 762402,2-二-正丙基乙酰基氯

产物 1

HCID 80191N-(2-propylpentanoyl)urea

试剂、催化剂与溶剂 1

HCID 6342乙腈溶剂2 次

实验过程

Valproyl chloride (0.057 mol), prepared by coupling of thionylchloride and valproic acid according to a published method [24], was dissolved in dry acetonitrile (50 ml), and the resulting solution was slowly added to a boiling solution of urea (0.14 mole) in dry acetonitrile (100 ml) and allowed to reflux for 2 hours. Thereafter the organic solvent was evaporated under reduced pressure and the product was dissolved in ethyl acetate (100 ml) and washed three times with 20 ml of distilled water. The organic fraction was dried over MgSO4, filtered and evaporated under reduced pressure. The products were purified by crystallization from ethyl acetate.

后处理

  1. temperatureto reflux for 2 hours
  2. customThereafter the organic solvent was evaporated under reduced pressure
  3. dissolutionthe product was dissolved in ethyl acetate (100 ml)
  4. washwashed three times with 20 ml of distilled water
  5. dry with materialThe organic fraction was dried over MgSO4
  6. filtrationfiltered
  7. customevaporated under reduced pressure
  8. customThe products were purified by crystallization from ethyl acetate

来源与证据

ORD记录
ord-b43ccd2aa5be4a4bb1e813a1bc026e6d
来源数据集
uspto-grants-2014_09
专利号
US08846903B2

关联笔记

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