三苯基膦 → 三苯基(3,3,3-三氟丙基)碘化膦

HRID 854

反应方程式

HRID 854 反应方程式
[C:1]1([P:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:20][C:21]([F:26])([F:25])[CH2:22][CH2:23][I:24]>>[I-:24].[F:20][C:21]([F:26])([F:25])[CH2:22][CH2:23][P+:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

参与物

3

反应物 2

HCID 11776三苯基膦HCID 1561651-碘-3,3,3-三氟丙烷

产物 1

HCID 19694095三苯基(3,3,3-三氟丙基)碘化膦收率 76.5%

实验过程

A solution of triphenylphosphine (Aldrich, 11.7 g) and 3,3,3-trifluoropropyl iodid (Lancaster, 10 g) was vigorously refluxed in xylenes (75 mL) for 2 days. The solid which formed was filtered and washed with xylenes then air dried to yield a white solid (16.6 g). 1H NMR and elemental analysis are consistent with the proposed structure.

后处理

  1. customThe solid which formed
  2. filtrationwas filtered
  3. washwashed with xylenes
  4. customair dried

来源与证据

ORD记录
ord-05670d53f7f64813b11aec885e767cda
来源数据集
uspto-grants-1998_03
专利号
US05723458

关联笔记

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