2-Methylthiomethyl-3,4,6-trifluoroaniline → 3,4,6-Trifluoro-2-methylaniline

HRID 864327

反应方程式

HRID 864327 反应方程式
CS[CH2:3][C:4]1[C:10]([F:11])=[C:9]([F:12])[CH:8]=[C:7]([F:13])[C:5]=1[NH2:6]>[Ni].C(O)C>[CH3:3][C:4]1[C:10]([F:11])=[C:9]([F:12])[CH:8]=[C:7]([F:13])[C:5]=1[NH2:6]

参与物

4

反应物 1

HCID 189744612-Methylthiomethyl-3,4,6-trifluoroaniline

产物 1

HCID 226251783,4,6-Trifluoro-2-methylaniline收率 71.3%

试剂、催化剂与溶剂 2

HCID 935Nickel催化剂HCID 702乙醇溶剂

实验过程

To 2-methylthiomethyl-3,4,6-trifluoroaniline (22.2 g) are added ethanol (400 ml) and Raney nickel (200 g) and the mixture is stirred at room temperature for 30 minutes. After the catalyst is filtered off, the filtrate is added with water and extracted with dichloromethane. The is dried over magnesium sulfate and concentrated to give 2-methyl-3,4,6-trifluoroaniline (12.3 g).

后处理

  1. filtrationAfter the catalyst is filtered off
  2. additionthe filtrate is added with water
  3. extractionextracted with dichloromethane
  4. dry with materialThe is dried over magnesium sulfate
  5. concentrationconcentrated

来源与证据

ORD记录
ord-909b848f416c4d2fb54608b479e09d05
来源数据集
uspto-grants-1996_10
专利号
US05563138

关联笔记

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