二苯基硅烷 → 4-(4-Bromo-3-fluorobenzyl)morpholine

HRID 874499

反应方程式

HRID 874499 反应方程式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=O)=[CH:4][C:3]=1[F:16].C1([SiH2]C2C=CC=CC=2)C=CC=CC=1>C1COCC1.C=O.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Rh]>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:10]2[CH2:11][CH2:12][O:13][CH2:14][CH2:15]2)=[CH:4][C:3]=1[F:16]

参与物

5

反应物 2

HCID 69888二苯基硅烷HCID 48474115(4-Bromo-3-fluorophenyl)(morpholin-4-yl)methanone

产物 1

HCID 534178184-(4-Bromo-3-fluorobenzyl)morpholine

试剂、催化剂与溶剂 2

HCID 53249357Carbonyltris(triphenylphosphine)rhodium(I)hydride催化剂HCID 8028四氢呋喃溶剂

实验过程

A 250 ml flask was charged with (4-bromo-3-fluorophenyl)(morpholino)methanone (4.569 g, 15.86 mmol) and dissolved in 16 mL of THF. Diphenylsilane (6.2 ml, 33.4 mmol) was added followed by carbonyltris(triphenylphosphine)rhodium(I)hydride (100 mg, 0.109 mmol) and the reaction stirred at room temperature for 20 hours.

来源与证据

ORD记录
ord-010ece6468994f4184278acfaf9b07f0
来源数据集
uspto-grants-2015_03
专利号
US08980890B2

关联笔记

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