十一烯酸 → 1-Undecene, 11-fluoro-

HRID 879950

反应方程式

HRID 879950 反应方程式
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12]CCC.C(OCC(F)(F)[F:31])(=O)CCCCCCCCC#C.C(OCC(F)(F)F)(=O)CCCCCCCCC=C.C(O)(=O)CCCCCCCCC#C.C(O)(=O)CCCCCCCCC=C.FC(F)(F)CO.C1(N=C=NC2CCCCC2)CCCCC1>CS(C)=O.CN(C)C1C=CN=CC=1>[F:31][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH:11]=[CH2:12]

参与物

10

反应物 7

HCID 5634十一烯酸HCID 64092,2,2-三氟乙醇HCID 8208溴代十四烷HCID 10868N,N'-二环己基碳二亚胺HCID 3103910-十一碳炔酸HCID 114825012,2,2-trifluoroethyl Undec-10-enoateHCID 866583042,2,2-Trifluoroethyl undec-10-ynoate

产物 1

HCID 680461-Undecene, 11-fluoro-

试剂、催化剂与溶剂 2

HCID 142844-二甲氨基吡啶(DMAP)催化剂HCID 679二甲基亚砜溶剂

实验过程

Glassware used for surface modification was cleaned with organic solvents and etched overnight in basic detergent solution. Prior to use, it was rinsed with ultrapure water and dried at 120° C. 1-Hexadecene (98%, Sigma-Aldrich) was purified by column chromatography and vacuum distillation. 1-Hexadecyne was obtained by reacting 1-bromotetradecane with lithium acetylide ethylenediamine complex in dimethylsulfoxide. 11-Fluoroundec-1-ene was synthesized as described elsewhere.14 2,2,2-Trifluoroethyl undec-10-ynoate and 2,2,2-trifluoroethyl undec-10-enoate were synthesized by esterification of 10-undecynoic acid, respectively 10-undecenoic acid, with 2,2,2-trifluoroethanol using N,N′-dicyclohexylcarbodiimide as a coupling reagent and 4-dimethylaminopyridine as a catalyst. Solvents used were either of analytical grade or distilled prior to use.

后处理

  1. distillationdistilled

来源与证据

ORD记录
ord-0b2f3dd8dcb24da89fa6a77c85fd4e20
来源数据集
uspto-grants-2015_03
专利号
US08993479B2

关联笔记

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