参与物
| 角色 | 名称 | HCID | 投料 |
|---|
| 反应物 | 4-溴-2-硝基苯甲醚 | HCID 118533 | — |
| 反应物 | 1-(9-Oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)ethan-1-one | HCID 68592728 | — |
| 试剂 | 叔丁醇钠 | HCID 23676156 | — |
| 催化剂 | 4,5-双二苯基膦-9,9-二甲基氧杂蒽 | HCID 636044 | — |
| 催化剂 | 醋酸钯 | HCID 4144353 | — |
| 溶剂 | 1,4-二氧六环 | HCID 31275 | — |
| 产物 | 1-(7-(4-Methoxy-3-nitrophenyl)-9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)ethanone | HCID 68592987 | 0% |
反应步骤
1-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)ethanone (36.3 mg, 0.21 mmol), 4-bromo-1-methoxy-2-nitrobenzene (45 mg, 0.19 mmol), diacetoxypalladium (3.48 mg, 0.02 mmol), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (8.98 mg, 0.02 mmol) and sodium 2-methylpropan-2-olate (28.0 mg, 0.29 mmol) in dioxane (0.5 mL) were degassed with nitrogen and stirred at 110 °C for 4 hours => _some product formed, by-products are major + degradation_ **_ABANDONED_**
来源与证据
| 来源数据集 | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-089e5915f1ae4e9e8fd817c5c0f3bd24 |
|---|
| 来源说明 | 750 AstraZeneca ELN dataset |
|---|
