硼氢化钠 → 4-Bromo-3-chloro-3,4,4-trifluorobutan-1-ol

HRID 938

反应方程式

HRID 938 反应方程式
[Br:1][C:2]([F:10])([F:9])[C:3]([Cl:8])([F:7])[CH2:4][CH:5]=[O:6].[BH4-].[Na+]>>[Br:1][C:2]([F:10])([F:9])[C:3]([Cl:8])([F:7])[CH2:4][CH2:5][OH:6]

参与物

3

反应物 2

HCID 4311764硼氢化钠HCID 218364804-Bromo-3-chloro-3,4,4-trifluorobutanal

产物 1

HCID 218364774-Bromo-3-chloro-3,4,4-trifluorobutan-1-ol

实验过程

Alternatively, the intermediate VII can be reduced with sodium borohydride without isolation to give 4-bromo-3-chloro-3,4,4-trifiuorobutanol ((IX) in high yield; or by hydrolysis of 1,4-dibromo-2-chloro-1,1,2-trifiuorobutane (XVI) to give IX. Oxidation of IX with Jones reagent to give VIII in 85% yield.

来源与证据

ORD记录
ord-4d3c86752d15461798923a512c8e5d21
来源数据集
uspto-grants-1998_03
专利号
US05723470

关联笔记

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