巯基乙胺 → 硫代吗啉-3-羧酸乙酯

HRID 976967

反应方程式

HRID 976967 反应方程式
[NH2:1][CH2:2][CH2:3][SH:4].C(N(CC)CC)C.Br[CH:13]([CH2:19]Br)[C:14]([O:16][CH2:17][CH3:18])=[O:15].C(Cl)(Cl)Cl.C1(C)C=CC=CC=1>C(Cl)(Cl)Cl>[NH:1]1[CH2:2][CH2:3][S:4][CH2:19][CH:13]1[C:14]([O:16][CH2:17][CH3:18])=[O:15]

参与物

6

反应物 4

HCID 6058巯基乙胺HCID 8471三乙胺HCID 979452,3-二溴丙酸乙酯HCID 22987606Toluene trichloromethane

产物 1

HCID 13604869硫代吗啉-3-羧酸乙酯

试剂、催化剂与溶剂 1

HCID 6212三氯甲烷溶剂

实验过程

A warm solution of 2-aminoethanethiol (10.0 g, 0.130 mol) and triethylamine (36 mL, 0.260 mol) in chloroform is added over 5 minutes to a solution of ethyl 2,3-dibromopropionate (33.9 g, 0.130 mol) in a chloroform/toluene (1:1.6) solution. The reaction mixture is stirred at room temperature for 2.5 hours, filtered and concentrated in vacuo to obtain an orange liquid. The liquid is vacuum distilled to give the title product as a colorless liquid, bp 121°-124° C. at 3 mm Hg.

后处理

  1. filtrationfiltered
  2. concentrationconcentrated in vacuo
  3. customto obtain an orange liquid
  4. distillationdistilled

来源与证据

ORD记录
ord-b6b1205ffcf04966b6c5f6167c66c676
来源数据集
uspto-grants-1997_03
专利号
US05612481

关联笔记

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