DL-Estradiol → Estradiol; Norethindrone Acetate

HRID 988926

反应方程式

HRID 988926 反应方程式
[CH3:1][C@@:2]12[C@@H:18]([OH:19])[CH2:17][CH2:16][C@H:15]1[C@H:14]1[C@@H:5]([C:6]3[CH:7]=[CH:8][C:9]([OH:20])=[CH:10][C:11]=3[CH2:12][CH2:13]1)[CH2:4][CH2:3]2.[CH3:21][C:22]([O:24][C@:25]1([C:44]#[CH:45])[C@@:29]2([CH3:43])[CH2:30][CH2:31][C@@H:32]3[C@@H:42]4[C:36](=[CH:37][C:38]([CH2:40][CH2:41]4)=[O:39])[CH2:35][CH2:34][C@H:33]3[C@@H:28]2[CH2:27][CH2:26]1)=[O:23].CC(O)COC(CO)C.C(O)CCCCCCC/C=C\CCCCCCCC>C(O)(C)C.C1(C)C=CC=CC=1.C(OCC)(=O)C>[CH3:1][C@@:2]12[C@@H:18]([OH:19])[CH2:17][CH2:16][C@H:15]1[C@H:14]1[C@@H:5]([C:6]3[CH:7]=[CH:8][C:9]([OH:20])=[CH:10][C:11]=3[CH2:12][CH2:13]1)[CH2:4][CH2:3]2.[CH3:21][C:22]([O:24][C@:25]1([C:44]#[CH:45])[C@@:29]2([CH3:43])[CH2:30][CH2:31][C@@H:32]3[C@@H:42]4[C:36](=[CH:37][C:38]([CH2:40][CH2:41]4)=[O:39])[CH2:35][CH2:34][C@H:33]3[C@@H:28]2[CH2:27][CH2:26]1)=[O:23]

参与物

9

反应物 5

HCID 5757DL-EstradiolHCID 5832炔诺酮醋酸酯HCID 328812-(2-羟基丙氧基)-1-丙醇HCID 5284499油醇HCID 178527255HCID 178527255，化合物

产物 1

HCID 3045253Estradiol; Norethindrone Acetate

试剂、催化剂与溶剂 3

HCID 1140甲苯溶剂HCID 3776异丙醇溶剂HCID 8857乙酸乙酯溶剂

实验过程

An estradiol/norethindrone acetate pressure-sensitive adhesive matrix composition was prepared by combining 0.7 parts of estradiol and 3.0 parts of norethindrone acetate along with 3.0 parts of ethyl cellulose (Ethocele® 10, Dow Chemical Corp., Midland, Mich.) in 30.0 parts ethyl acetate, 15.0 parts of toluene and 10.0 parts isopropyl alcohol. Then 12.2 parts of a polyacrylate adhesive (DURO-TAIE® 87-2510; National Starch Company, Bridgewater, N.J.) and 109.2 parts of a polysiloxane adhesive (BIO-PSA® Q7-4603; Dow Corning Corp, Midland, Mich.) were added and thoroughly mixed. Finally 9.0 parts of dipropylene glycol and 6.0 parts oleyl alcohol were added and mixed thoroughly in an appropriate container until the mixture was completely homogenous. The resulting composition had the ingredient concentrations on a dry weight percent basis (i.e., after evaporation of volatile solvents) as shown below.

后处理

  1. additionthoroughly mixed
  2. additionmixed thoroughly in an appropriate container until the mixture
  3. concentrationthe ingredient concentrations
  4. customon a dry weight percent basis (i.e., after evaporation of volatile solvents)

来源与证据

ORD记录
ord-19b297349b4b464a94791fb9bf448537
来源数据集
uspto-grants-2003_10
专利号
US06638528B1

关联笔记

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