邻氨基苯甲酸 → 2-(甲苯-4-磺酰基氨基)-苯甲酸

HRID 990108

反应方程式

HRID 990108 反应方程式
C(=O)([O-])[O-].[Na+].[Na+].[C:7]([OH:16])(=[O:15])[C:8]1[C:9](=[CH:11][CH:12]=[CH:13][CH:14]=1)[NH2:10].[C:17]1([CH3:27])[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=1.Cl>O>[CH3:27][C:17]1[CH:22]=[CH:21][C:20]([S:23]([NH:10][C:9]2[C:8](=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:7]([OH:16])=[O:15])(=[O:25])=[O:24])=[CH:19][CH:18]=1

参与物

6

反应物 4

HCID 227邻氨基苯甲酸HCID 313海萝胶HCID 7397对甲苯磺酰氯HCID 10340Carbonic acid sodium salt (1:2)

产物 1

HCID 227632-(甲苯-4-磺酰基氨基)-苯甲酸

试剂、催化剂与溶剂 1

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

实验过程

A solution of 3.45 g (25 mmol) of sodium carbonate and 1.0 g (7.3 mmol) of anthranilic acid in 50 ml of water at 60° was treated with 2.09 g (10.95 mmol) of p-toluenesulfonyl chloride and held at 70° for 30 min. The reaction mixture was cooled to ambient temperature and acidified with 10% HCl. After standing for 18 hr the product was collected by filtration, washed with water and dried to give N-4-methylphenylsulfonylanthranilic acid as a solid, mp 226-229°.

后处理

  1. waitAfter standing for 18 hr
  2. filtrationthe product was collected by filtration
  3. washwashed with water
  4. customdried

来源与证据

ORD记录
ord-8ea78ecd93754de4ba3e88942421c7d1
来源数据集
uspto-grants-2002_10
专利号
US06458845B1

关联笔记

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