Tripotassium citrate

Between 7,5 and 9,0 (5 % aqueous solution)

THE AQ SOLN IS ALKALINE TO LITMUS; PH ABOUT 8.5

ODORLESS

HAS COOLING, SALINE TASTE

1.98 @25 °C

WHITE CRYSTALS, GRANULES, OR POWDER

TRANSPARENT CRYSTALS

1 G DISSOLVES IN 0.65 ML WATER

1 G DISSOLVES VERY SLOWLY IN 2.5 ML GLYCEROL

ALMOST INSOL IN ALCOHOL

Liquid

Liquid; Large Crystals; Dry Powder

White, hygroscopic, granular powder or transparent crystals

Monohydrate: White odorless solid; [Merck Index] White odorless crystalline granules; [MSDSonline]

LOSES WATER AT 180 °C

This chemical does not meet GHS hazard criteria for 96.3% (572 of 594) of all reports.

Not Classified；Reported as not meeting GHS hazard criteria by 572 of 594 companies (only 3.7% companies provided GHS information). For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 594 reports by companies from 4 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 572 of 594 reports by companies.；There are 2 notifications provided by 22 of 594 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

This chemical does not meet GHS hazard criteria for 100% (14 of 14) of all reports.

Not Classified；Reported as not meeting GHS hazard criteria by 14 of 14 companies. For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 14 reports by companies from 2 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 14 of 14 reports by companies.；There are 0 notifications provided by 0 of 14 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 19-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14309

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt: Does not have an individual approval but may be used under an appropriate group standard

IMAP assessments - 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt: Human health tier I assessment

Potassium salts by mouth in doses less than 2 mEq/kg are usually not toxic in patients with normal renal function; [HSDB] May cause irritation; [MSDSonline]

121.101; LIMITATIONS: GRAS SEQUESTRANT; GRAS MISCELLANEOUS AND/OR GENERAL-PURPOSE FOOD ADDITIVE.

Chemical: Potassium citrate, anhydrous； Green circle - The chemical has been verified to be of low concern based on experimental and modeled data.

Not Classified

Not Classified

2.1 [mg/m3]

23 [mg/m3]

140 [mg/m3]

12 OF 40 HEART PT TREATED WITH POTASSIUM CITRATE SHOWED SLIGHT MALABSORPTION OF VITAMIN B12. MECHANISM OF THE DISTURBANCE APPEARED TO BE ACIDIFICATION OF CONTENTS OF THE ILEUM.

CONGENITAL MALFORMATIONS AND SURVIVAL IN RELATION TO THE FIRST TRIMESTER USE OF SPECIFIC DRUGS AND VACCINES ARE PRESENTED.

Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 19-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14309

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt: Does not have an individual approval but may be used under an appropriate group standard

121.101; LIMITATIONS: GRAS SEQUESTRANT; GRAS MISCELLANEOUS AND/OR GENERAL-PURPOSE FOOD ADDITIVE.

86R1NVR0HW

POTASSIUM CITRATE ANHYDROUS

Mechanisms of Action [MoA] - Alkalinizing Activity

Established Pharmacologic Class [EPC] - Metabolic Alkalinizer

Potassium citrate anhydrous is a Metabolic Alkalinizer. The mechanism of action of potassium citrate anhydrous is as an Alkalinizing Activity.

Agents that promote the excretion of urine through their effects on kidney function.

Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here.

Used as a food additive (sequestrant, stabilizer, and buffer), a preservative for cut flowers, and a medication (potassium supplement, diuretic, expectorant, and alkalizer); [HSDB] Used as chemical intermediate; [MSDSonline]

MEDICATION

MEDICATION (VET)

SEQUESTRANT FOOD ADDITIVE

STABILIZER, BUFFER IN FOODS

IN PRESERVATION OF CUT FLOWERS

2023: 75,000 - <100,000 lb；2022: 75,000 - <100,000 lb；2021: 75,000 - <100,000 lb；2020: 50,000 - <250,000 lb

2023: 1,000,000 - <2,500,000 lb；2022: 2,500,000 - <4,000,000 lb；2021: 2,500,000 - <4,000,000 lb；2020: 1,000,000 - <2,500,000 lb

Soil amendments (fertilizers)；Emulsifier

pH regulating agent；Soil amendments (fertilizers)；Emulsifier

BY ADDING POTASSIUM BICARBONATE OR CARBONATE TO A SOLN OF CITRIC ACID UNTIL EFFERVESCENCE CEASES, FILTERING THE SOLN & EVAPORATION TO GRANULATION.

POTASSIUM CITRATE, NF. POWDER, NF. TABLETS, 2.3 MEQ OF K+ AND 0.8 MEQ OF C6H5O7(3-) (250 MG), 2.8 MEQ OF K+ AND 0.9 MEQ OF C6H5O7(3-) (300 MG), AND 5.6 MEQ OF K+ AND 1.8 MEQ OF C6H5O7(3-) (600 MG).

IT IS AT LEAST 99% PURE.

GRADES: TECHNICAL; CP; NF; FCC.

Information on 2 consumer products that contain Potassium Citrate in the following categories is provided:；• Commercial / Institutional

EPA Safer Chemical Functional Use Classes -> Chelating Agents;Processing Aids and Additives

Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern

Food additives

Fragrance Ingredients

Food Additives -> ACIDITY_REGULATOR; SEQUESTRANT; STABILIZER -> JECFA Functional Classes

Food Additives -> ACIDITY_REGULATOR; SEQUESTRANT; STABILIZER -> JECFA Functional Classes

Other (requires additional information)；Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing；Soap, Cleaning Compound, and Toilet Preparation Manufacturing

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3): ACTIVE

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?): ACTIVE

INCOMPATIBILITIES: AQUEOUS SOLUTIONS...WILL REACT WITH ACIDIC SUBSTANCES. ALKALOIDAL SALTS MAY BE PPT FROM...AQ OR HYDROALCOHOLIC SOLN. ACIDIFICATION OR ADDITION OF ALCOHOL WILL RESTORE SOLN. CALCIUM & STRONTIUM SALTS CAUSE PRECIPITATION OF CORRESPONDING CITRATES.