Cadmium stearate

Free fatty acid: 2 wt%; total ash 19-20 wt%; moisture: 1 wt%. Bulk density: 180 g/L

White powder

Solid

When heated to decomposition it emits toxic fumes of /cadmium/.

105-115 °C

Cadmium stearate is a solid. Used as a lubricant and stabilizer for polyvinyl chloride. (EPA, 1998)

Solid; [CAMEO] White powder; [MSDSonline]

Danger

H302+H312 (25.3%): Harmful if swallowed or in contact with skin [Warning Acute toxicity, oral; acute toxicity, dermal]；H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]；H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]；H330 (25.3%): Fatal if inhaled [Danger Acute toxicity, inhalation]；H332 (74.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]；H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]；H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P260, P261, P264, P270, P271, P273, P280, P284, P301+P317, P302+P352, P304+P340, P316, P317, P320, P321, P330, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 154 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Chemical: Octadecanoic acid, cadmium salt

Chemical: Octadecanoic acid, cadmium salt, basic

Restricted substance: Cadmium distearate；EC: 218-743-6；Restriction condition document: PDF link

Restricted substance: Octadecanoic acid, cadmium salt, basic；EC: 309-794-6；Restriction condition document: PDF link

Cadmium stearate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

IMAP assessments - Cadmium(2+) salts of medium- and long-chain carboxylic acids: Environment tier II assessment；IMAP assessments - Cadmium salts of selected fatty acids: Human health tier II assessment

IMAP assessments - Cadmium(2+) salts of medium- and long-chain carboxylic acids: Environment tier II assessment；IMAP assessments - Cadmium salts of selected fatty acids: Human health tier II assessment

Poison

It emits acrid smoke when heated to decomposition. (EPA, 1998)

Similar to cadmium; acute toxicity most notably occurs secondary to cadmium ingestion or inhalation of cadmium fumes. Poisoning from inhalation is relatively rare but dangerous, having a mortality rate of about 15 percent. Toxic inhaled concentrations in humans have been reported at 147 mg/m3/35 minutes and at 1800 mg/m3/2 years. (EPA, 1998)

May cause irritation; Inhalation or ingestion may cause cadmium poisoning; [MSDSonline] See Cadmium and the linked diseases.

Hydrocarbons, Aliphatic Saturated；Salts, Basic

National Toxicology Program. Eleventh Report on Carcinogens (2005). The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. Cadmium and Cadmium Compounds are listed as known to be human carcinogens. /Cadmium and Cadmium Compounds/[Available from, as of July 31, 2009: http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s028cadm.pdf]

D006; A solid waste containing cadmium may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste. /Cadmium/

CADMIUM STEARATE has weak oxidizing or reducing powers. Redox reactions can however still occur. The majority of compounds in this class are slightly soluble or insoluble in water. If soluble in water, then the solutions are usually neither strongly acidic nor strongly basic. These compounds are not water-reactive.

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Cadmium stearate is included on this list.

/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Cadmium compound/

/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. /Cadmium compound/

/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Cadmium compound/

/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Cadmium compound/

For more DOT Emergency Guidelines (Complete) data for CADMIUM STEARATE (8 total), please visit the HSDB record page.

(Non-Specific -- Cadmium Compound) Keep upwind; keep out of low areas. Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing.；(Non-Specific -- Cadmium Compound) For small fires, use dry chemicals, carbon dioxide, water spray, or foam. For large fires, use water spray, fog, or foam. (EPA, 1998)

Warning: Effects may be delayed for several hours. Caution is advised.；Signs and Symptoms of Acute Cadmium Stearate Exposure: The following signs and symptoms may be noted following exposure to cadmium stearate: cough, dyspnea (shortness of breath), either dry mouth or increased salivation, abdominal pain, nausea, vomiting, bronchitis, and chest pain. Vertigo (dizziness), fever, and profuse sweating may also occur.；Emergency Life-Support Procedures: Acute exposure to cadmium stearate may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.；Inhalation Exposure:；1. Move victims to fresh air. Emergency personnel should avoid self-exposure to cadmium stearate.；2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.；3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.；4. Transport to a health care facility.；Dermal/Eye Exposure:；1. Remove victims from exposure. Emergency personnel should avoid self- exposure to cadmium stearate.；2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.；3. Remove contaminated clothing as soon as possible.；4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.；5. Wash exposed skin areas THOROUGHLY with soap and water.；6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.；7. Transport to a health care facility.；Ingestion Exposure:；1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.；2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.；3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of cadmium stearate is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step

Biological Exposure Indices (BEI) [ACGIH] - Cd in urine = 5 ug/g creatinine; Cd in blood = 5 ug/L; sampling time not critical; Monitoring in blood should be preferred during the initial year of exposure and whenever changes in the degree of exposure are suspected. [ACGIH]；TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol" foam, dry chemical or carbon dioxide. /Cadmium compounds, NOS/

(Non-Specific -- Cadmium Compounds) Do not touch spilled material. Stay upwind; keep out of low areas. Take up small spills with sand or other noncombustible absorbent material and place into containers for later disposal. Take up small, dry spills with clean shovel and place into clean, dry container. Dike far ahead of large spills for later disposal. (EPA, 1998)

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D006, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste. /Cadmium/

Precipitate from solution as sulfides, drying and return to suppliers. /Cadmium compounds/

The following wastewater treatment technology has been investigated for cadmium: Concentration process: Reverse Osmosis. /Cadmium/

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:；IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.；SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.；FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

0.01 [mg/m3], as Cd ( 0.002 mg/m3, as Cd, respirable fraction)

8 hr Time Weighted Avg (TWA): 0.01 mg/cu m /Cadmium and compounds, as Cd/

8 hr Time Weighted Avg (TWA): 0.002 mg/cu m (respirable fraction) /Cadmium and compounds, as Cd/

A2; Suspected human carcinogen. /Cadmium and compounds, as Cd/

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded. /Cadmium and compounds, as Cd/

0.005 [mg/m3], as Cd, see 29 CFR 1910.1027

0.30 [mg/m3]

1.3 [mg/m3]

4.5 [mg/m3]

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

9.0 [mg/m3], as Cd

LC50; Species: Oncorhynchus mykiss (Rainbow Trout) fingerling, length 6 cm, weight 2.5 g; Conditions: freshwater, static, 16.8 °C, pH 7.2-7.3; Concentration: 5.2 ug/L for 10 days /total Cd ion/

LC50; Species: Oncorhynchus mykiss (Rainbow Trout) fingerling, length 6 cm, weight 2.5 g; Conditions: freshwater, static, 16.8 °C, pH 7.2-7.3; Concentration: 7.5 ug/L for 48 hr /total Cd ion/

LC50; Species: Oncorhynchus mykiss (Rainbow Trout) fingerling, length 6 cm, weight 2.5 g; Conditions: freshwater, static, 16.8 °C, pH 7.2-7.3; Concentration: 6 ug/L for 96 hr /total Cd ion/

Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.；Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

In preemployment physical examinations emphasis should be given to a history of, or actual presence of, significant kidney disease, smoking history, and respiratory disease. A chest x-ray and baseline pulmonary function study is recommended. Periodic examinations should emphasize the respiratory system, including pulmonary function tests, kidneys, and blood. A low molecular weight proteinuria may be the earliest indication of renal toxicity. The trichloroacetic acid test may pick this up, but more specific quantitative studies would be preferable. If renal disease due to cadmium is present, there may also be increased excretion of calcium, amino acids, glucose, and phosphates. /Cadmium and compounds/

/HUMAN EXPOSURE STUDIES/ In 1963, 27 exposed and 7 non-exposed workers from a polyvinyl chloride film plant in which lead and cadmium sterates were used as stablilzers /showed that/ urinary coproporphyrin levels were not increased in exposed workers compared to that of controls, and most of the urinary lead levels were below 200 ug/L. Although lead concentrations were higher than those of cadmium, particle sizes of lead compounds were larger than those of the cadmium stearate. Eight of 17 workers re-examined in 1964 had increases in the degree of urinary protein excretion by the trichloroacetic acid (TCA) test. The numbers that were positive were significantly greater in the exposed workers, than in the controls in the 1964 tests. Statistically, this might possibly have been due to the larger number of controls, and therefore, to a more normal distribution curve which is apparent in the 1964 data (24 controls in 1964 vs 7 controls in 1963). These increases were demonstrated by all three methods of testing for urinary protein, ... 25% TCA test, sulfosalicylic acid test, and boiling test. ... No significant differences in respiratory function were found between exposed and control groups. No significant differences in mean urinary cadmium levels were demonstrated, though there were a few slightly higher urinary cadmium levels in the exposed group. No differences in olfactory acuity between the two groups were shown. Yellow discoloration of the teeth of exposed workers was looked for but not found. Liver function ... was not significantly different in exposed and control groups. ... There were no significant differences in hemoglobin, urine specific gravity, urine occult blood, but there was a slight increase in urine sugar (by test tape) in exposed workers /over/ controls. Both groups had less than 0.05% of cells with basophillic stippling. ... Each work operation, involving exposure to lead stearate and cadmium stearate, as well as to organic plasticizers, took 20 mi

/SIGNS AND SYMPTOMS/ Chronic cadmium poisoning has been reported after prolonged occupational exposure to ... cadmium stearates. Changes associated with chronic cadmium poisoning may be local, in which case they involve the respiratory tract, or systemic, resulting from absorption of cadmium. Systemic changes include kidney damage with proteinuria and anemia. Obstructive lung disease in the form of emphysema is the main symptom at heavy exposure to cadmium in air, whereas kidney dysfunction and damage are the most prominent findings after long term exposure to lower levels of cadmium in workroom air or via cadmium contaminated food. Mild hypochromic anemia is frequently found among workers exposed to high levels of cadmium. This may be due to both increased destruction of red blood cells and iron deficiency. Yellow discoloration of the necks of teeth and anosmia may also be seen in cases of exposure to very high cadmium concentrations.

/OTHER TOXICITY INFORMATION/ ... /CADMIUM SOAPS SUCH AS CADMIUM STEARATE/ CAN GIVE RISE TO THE CORRESPONDING METAL CHLORIDES, WHICH ARE BOTH SOLUBLE AND TOXIC, WHEN THEY STABILIZE THE VINYL RESIN. HENCE THEY CANNOT BE USED TO PREPARE VINYL COMPOUNDS WHICH WILL BE USED IN THE FOOD INDUSTRY.

/LABORATORY ANIMALS: Acute Exposure/ MALE RATS WERE GIVEN A SINGLE INTRATRACHEAL DOSE OF 10 MG CADMIUM STEARATE. TWO MONTHS AFTER THE ADMINISTRATION, THERE WAS ULCERATION WITH LEUKOCYTIC REACTION, SYMPTOMS OF PNEUMOSCLEROSIS, CHRONIC PNEUMONIA, BRONCHOLITHIASIS, AND WIDESPREAD HEMORRHAGES. IN 4-6 MONTHS THEY SHOWED DILATION OF THE LARGE BRONCHI, THE ACCUMULATION OF LYMPHOCYTES, DIFFUSE PNEUMOSCLEROSIS, CHRONIC EMPHYSEMA, AND SMALL HEMORRHAGIC AREAS.

/LABORATORY ANIMALS: Neurotoxicity/ CADMIUM STEARATE AT 0.58X10-6 MOLAR INHIBITED THE NERVE FIBER AND GLIAL CELL OUTGROWTH FROM CULTURED SLICES OF CEREBELLUM OF 5-9 DAY OLD RATS, AND CAUSED FORMATION OF GRANULES IN THE NERVE FIBERS AND FIBROBLASTS.

/OTHER TOXICITY INFORMATION/ ORAL DOSES OF CADMIUM STEARATE (550 MG/KG) INDUCED TESTICULAR INFLAMMATION IN RATS.

CLASSIFICATION: B1; probable human carcinogen. BASIS FOR CLASSIFICATION: Limited evidence from occupational epidemiologic studies of cadmium is consistent across investigators and study populations. There is sufficient evidence of carcinogenicity in rats and mice by inhalation and intramuscular and subcutaneous injection. Seven studies in rats and mice wherein cadmium salts (acetate, sulfate, chloride) were administered orally have shown no evidence of carcinogenic response. HUMAN CARCINOGENICITY DATA: Limited. /Classification based on former EPA guidelines/

A2; Suspected human carcinogen. /Cadmium and compounds, as Cd/

Cadmium and Cadmium Compounds: known to be human carcinogens.

According to the 2006 TSCA Inventory Update Reporting data, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use of cadmium stearate is 1 to 99; the data may be greatly underestimated(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 14,378 workers (2,152 of these were female) were potentially exposed to cadmium stearate in the US(1).

Workers in a polyvinyl chloride film plant ... are at greater exposure risk to cadmium stearate. ...

REPORTED EXPOSURE LEVELS FROM THE PRODUCTION OF CADMIUM STEARATE PVC STABILIZERS /ARE/ 20-700 UG CADMIUM/CU M ... .

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Cadmium and Related Compounds/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Cadmium and Related Compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... .... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Cadmium and Related Compounds/

LC50 (rat) = 130 mg/m3/2h

LD50 Rat oral 1200 mg/kg bw

LD50 Rat oral 1225 mg/kg

LD50 Mouse oral 590 mg/kg

LD50 Rat oral 1125 mg/kg

LC50 Rat inhalation 130 mg/cu m/2 hours

Chemical: Octadecanoic acid, cadmium salt

Chemical: Octadecanoic acid, cadmium salt, basic

Restricted substance: Cadmium distearate；EC: 218-743-6；Restriction condition document: PDF link

Restricted substance: Octadecanoic acid, cadmium salt, basic；EC: 309-794-6；Restriction condition document: PDF link

Cadmium stearate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

D006; A solid waste containing cadmium may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste. /Cadmium/

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Cadmium stearate is included on this list.

Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Cadmium stearate is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 1,000 or 10,000 lbs. Extremely hazardous substances that are solids are subject to either of two threshold planning quantities ... The lower quantity applies only if the solid exists in powdered form and has a particle size less than 100 microns; or is handled in solution or in molten form; or meets the criteria for a National Fire Protection Association (NFPA) rating of 2, 3 or 4 for reactivity. If the solid does not meet any of these criteria, it is subject to the upper ... threshold planning quantity ... .

Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Cadmium and compounds/

(AZ) ARIZONA 10 ug/L /Cadmium/

(AZ) ARIZONA 5 ug/L /Cadmium/

(ME) MAINE 3. 5 ug/L /Cadmium/

(MN) MINNESOTA 4 ug/L /Cadmium/

Maximum contaminant levels for inorganic contaminants: 0.005 mg/L /Cadmium/

Maximum contaminant level goals for inorganic contaminants: 0.005 mg/L /Cadmium/

SLOW EXCRETION RESULTS IN VERY LONG BIOLOGICAL HALF LIFE FOR ABSORBED CADMIUM, WHICH HAS BEEN EST TO BE 16-33 YR ... . /CADMIUM/

THE PERCUTANEOUS ABSORPTION OF CADMIUM STEARATE WAS INVESTIGATED IN MICE, RATS, GUINEA PIGS, AND RABBITS. IT PENETRATES THE INTACT SKIN EASILY AND IS RETAINED IN THE LIVER AND KIDNEYS FOR A LONG PERIOD BEFORE IT IS SLOWLY EXCRETED.

Gastrointestinal absorption is less than respiratory absorption and is about 5 to 8 percent. It is enhanced by dietary deficiencies of calcium and iron, and diets low in protein. Low dietary calcium stimulates synthesis of calcium binding protein which enhances cadmium absorption. Women with low serum ferritin levels have been shown to have twice the normal absorption of cadmium. Zinc decreases cadmium absorption probably by stimulating production of metallothionein. /Cadmium/

Excretion by feces of normal humans is ca 30-50 ug/day ... retention of ingested cadmium varied between 4.7-7% in 5 adult men ... only very small proportions of daily absorbed dose will be excreted ... normal urinary excretion in humans amount to CA 1-2 ug/day ... on occupational exposure, this level is not raised significantly ... . /Cadmium/

EXCRETION BY FECES OF NORMAL HUMANS IS ABOUT 30-50 UG/DAY ... RETENTION OF INGESTED CADMIUM VARIED BETWEEN 4.7-7% IN 5 ADULT MEN ... ONLY VERY SMALL PROP OF DAILY ABSORBED DOSE WILL BE EXCRETED ... NORMAL URINARY EXCRETION IN HUMANS AMT TO ABOUT 1-2 UG/DAY ... ON OCCUPATIONAL EXPOSURE, THIS LEVEL IS NOT RAISED SIGNIFICANTLY ... /CADMIUM/

About half of total body burden is found in liver & kidneys. Cadmium in these organs is mainly bound to /a/ low molecular weight protein, in form of metallothionein ... . /Cadmium/

Used as lubricant and heat stabilizer in PVC plastics; [HSDB] Metallic soaps such as cadmium stearate are used as thickeners, lubricants, release agents, and drying agents; [Ullmann]

Lubricant and stabilizer in plastics.

An organocadmium soap incorporated into plastics to prevent early discoloration

Heat stabilizer in PVC plastics

(1979) PROBABLY GREATER THAN 2.27X10+6 G

(1981) PROBABLY GREATER THAN 2.27X10+6 G

Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#5425]

Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Octadecanoic acid, cadmium salt. Aggregated National Production Volume: < 500,000 pounds.

REACTION OF CADMIUM CHLORIDE WITH SODIUM STEARATE

... Prepared from cadmium chloride solution by precipitation with sodium salt of the fatty acid.

Octadecanoic acid, cadmium salt (2:1): ACTIVE

FDA regulations have decreed that plastics that contact foodstuffs may not contain Cd-Ba stabilizers ... a decrease in consumption of Cd compounds in the stabilizer field that began in the late 1970s.

CADMIUM SOAPS (STEARATE) ... ARE REMARKABLE FOR THE HIGH DEGREE OF TRANSPARENCY WHICH, EVEN IN SMALL AMOUNTS, THEY IMPART TO VINYL FILM (SHEET).