Ammonium Laureth Sulfate 分子结构式
HCID61913

Ammonium Laureth Sulfate

azane;2-dodecoxyethyl hydrogen sulfate

C14H33NO5S327.48 g/molCAS 32612-48-9

IDENTITY

结构与身份

标准SMILES
CCCCCCCCCCCCOCCOS(=O)(=O)O.N
InChIKey
OPVLOHUACNWTQT-UHFFFAOYSA-N
分子式
C14H33NO5S
平均分子量
327.48 g/mol
单同位素质量
327.20794433

COMPUTED

结构计算性质

已同步
极性表面积
82.2 Ų
氢键供体
2
氢键受体
6
可旋转键
15
重原子
21
形式电荷
0
复杂度
284

PROPERTIES

实验与物化性质

来源:PubChem
Physical Description

Light yellow viscous liquid; [MSDSonline]

GHS

GHS分类

来源:PubChem
GHS Classification

This chemical does not meet GHS hazard criteria for 12.6% (59 of 469) of reports.

Danger

H315 (87.4%): Causes skin irritation [Warning Skin corrosion/irritation];H318 (12.4%): Causes serious eye damage [Danger Serious eye damage/eye irritation];H319 (75.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

P264, P264+P265, P280, P302+P352, P305+P351+P338, P305+P354+P338, P317, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)

Aggregated GHS information provided per 469 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Reported as not meeting GHS hazard criteria per 59 of 469 reports by companies.;There are 5 notifications provided by 410 of 469 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

HAZARDS

危害信息

来源:PubChem
Regulatory Information

Chemical: Poly(oxy-1,2-ethanediyl), .alpha.-sulfo-.omega.-(dodecyloxy)-, ammonium salt (1:1)

Poly(oxy-1,2-ethanediyl), .alpha.-sulfo-.omega.-(dodecyloxy)-, ammonium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Poly(oxy-1,2-ethanediyl), .alpha.-sulfo-.omega.-(dodecyloxy)-, ammonium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

XU - indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).

Poly(oxyethylene) lauryl ether ammonium sulfate: Does not have an individual approval but may be used under an appropriate group standard

Other Safety Information

IMAP assessments - Sodium and ammonium laureth sulfate: Human health tier II assessment

Hazards Summary

An eye irritant; [MSDSonline]

EPA Safer Chemical

Chemical: Ammonium Laureth Sulfate ; Green circle - The chemical has been verified to be of low concern based on experimental and modeled data.

Hazard Classes and Categories

Skin Irrit. 2 (87.4%);Eye Dam. 1 (12.4%);Eye Irrit. 2 (75.1%)

Not Classified

Acute toxicity - category 4;Eye irritation - category 2A;Skin irritation - category 2

TOXICITY

毒理信息

来源:PubChem
Health Effects

Ammonium laureth sulfate itself only causes mild irritation. However, it may react to produce nitrosamines, which are believed to be carcinogenic. (L1888, L1890)

Exposure Routes

Oral (A2880) ; inhalation (A2880) ; dermal (L1889)

Toxicity Summary

Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org

While ammonium laureth sulfate itself is not toxic, it is a nitrosating agent. Nitrosating agents may decompose and/or react to cause nitrosamine contamination. Nitrosamines are produced from secondary amines and amides in the presence of nitrite ions and are believed to be carcinogenic. Once in the body, nitrosamines are activated by cytochrome P-450 enzymes. They are then believed to induce their carcinogenic effects by forming DNA adducts at the N- and O-atoms. (L1889, L1890, A2878, A2879, A2880)

Signs and Symptoms

Ammonium laureth sulfate can cause mild irritation. (L1888)

Carcinogen Classification

Not listed by IARC. Certain nitrosamines are classified by IARC as either probably or possibly carcinogenic to humans (Groups 2A and 2B, respectively). (L135)

REGULATORY

法规信息

来源:PubChem
Regulatory Information

Chemical: Poly(oxy-1,2-ethanediyl), .alpha.-sulfo-.omega.-(dodecyloxy)-, ammonium salt (1:1)

Poly(oxy-1,2-ethanediyl), .alpha.-sulfo-.omega.-(dodecyloxy)-, ammonium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Poly(oxy-1,2-ethanediyl), .alpha.-sulfo-.omega.-(dodecyloxy)-, ammonium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

XU - indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).

Poly(oxyethylene) lauryl ether ammonium sulfate: Does not have an individual approval but may be used under an appropriate group standard

PHARMACOLOGY

药理信息

来源:PubChem
Metabolism/Metabolites

Nitrosamines can enter the body via ingestion, inhalation, or dermal contact. Once in the body, nitrosamines are metabolized by cytochrome P-450 enzymes, which essentially activates them into carcinogens. (A2878, A2879)

USES

用途与制造

来源:PubChem
Uses

CIR ingredient: Ammonium Laureth Sulfate

Used as a foaming and cleansing agent in shampoos and cleaners; [MSDSonline]

Ammonium laureth sulfate is a surfactant often found in shampoos. (L1888)

U.S. Production

2022: 11,000 lb;2021: 50,600 lb;2020: 22,000 lb

Household Products

Information on 205 consumer products that contain Ammonium laureth sulfate in the following categories is provided:;• Auto Products;• Commercial / Institutional;• Inside the Home;• Personal Care;• Pet Care

Use Classification

EPA Safer Chemical Functional Use Classes -> Surfactants

Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern

Cosmetics -> Foaming; Surfactant; Cleansing

General Manufacturing Information

Poly(oxy-1,2-ethanediyl), .alpha.-sulfo-.omega.-(dodecyloxy)-, ammonium salt (1:1): ACTIVE

ALIASES

名称与别名

共 15 条
(2-(dodecyloxy)ethoxy)sulfonic acid amine32612-48-943ZIH89I489C50N72CDB9LPV636QCVAmmonium Laureth SulfateE1ZP93931SPEG-(1-4) Lauryl ether sulfate, ammonium saltPEG-12 Lauryl ether sulfate, ammonium saltPEG-5 Lauryl ether sulfate, ammonium saltPEG-7 Lauryl ether sulfate, ammonium saltPEG-9 Lauryl ether sulfate, ammonium saltRefChem:1076669azane;2-dodecoxyethyl hydrogen sulfateSCHEMBL675554

REACTIONS

参与反应

3
HRID 265226 反应方程式

uspto-grants-1997_07 · 10.6084/m9.figshare.5104873.v1 · US05648323

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HRID 840338 反应方程式

uspto-grants-2002_04 · 10.6084/m9.figshare.5104873.v1 · US06365709B1

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HRID 2303752 反应方程式

uspto-grants-2002_08 · 10.6084/m9.figshare.5104873.v1 · US06433132B1

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