Vinyl Fluoride

log Kow = 1.19 /Estimated/

Faint, ethereal odor.

0.707 at 32 °F (USCG, 1999) - Less dense than water; will float

0.636 (liquid) at 21 °C

Heat of evaporation: 13494 J/mol at -20 °C; Density = 0.775 g/cu cm at -30 °C; Critical density = 0.320 g/cu cm

0.707 at 32 °F

0.636 @ 21°C (Liquid)

1.60(relative gas density)

3.2347E-04 pascal/seconds (liquid) @ boiling point

Colorless gas [Note: Shipped as a liquefied compressed gas].

Insoluble (NIOSH, 2024)

Soluble in ether.

Soluble in ethanol and acetone

Water solubility at 80 °C (g/100 g water): 0.94 (at 3.4 MPa), 1.54 (at 6.9 MPa)

In water, 1.29X10+4 mg/L at 25 °C /Estimated/

Solubility in water: none

Flammable gas

NA (Gas)

-98 °F at 760 mmHg (USCG, 1999)

-72 °C

-72 °C

-98 °F

-72 °C @760 [mm Hg]

-98 °F

When heated to decomposition it emits toxic fumes of /hydrogen fluoride/.

-258 °F (USCG, 1999)

-160.5 °C

-161 °C

-257 °F

-160.5 °C

-257 °F

1.6 (NIOSH, 2024) - Heavier than air; will sink (Relative to Air)

1.58 (Air= 1)

Relative vapor density (air = 1): 1.6

1.6

In the absence of inhibitor, polymerization can occur

Polymerizes freely

Danger

H220 (100%): Extremely flammable gas [Danger Flammable gases]；H280 (100%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]；H341 (45.6%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]；H350 (45.6%): May cause cancer [Danger Carcinogenicity]；H373 (45.6%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P203, P210, P222, P260, P280, P318, P319, P377, P381, P403, P405, P410+P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 114 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Chemical: Ethene, fluoro-

Hazard Traits - Carcinogenicity；Authoritative List - IARC Carcinogens - 2A; NTP RoC - reasonable; Prop 65；Report - regardless of intended function of ingredient in the product

Ethene, fluoro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethene, fluoro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 30-01-2014 https://echa.europa.eu/registration-dossier/-/registered-dossier/10395

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

IMAP assessments - Ethene, fluoro-: Human health tier II assessment；IMAP assessments - Ethene, fluoro-: Environment tier I assessment

Flammable Gas

Special Hazards of Combustion Products: Toxic hydrogen fluoride gas is generated in a fire.；Behavior in Fire: Vapor is heavier than air and may travel considerable distance to a source of ignition and flash back. Containers may explode. (USCG, 1999)

· EXTREMELY FLAMMABLE.；· Will be easily ignited by heat, sparks or flames.；· Will form explosive mixtures with air. Acetylene (UN1001, UN3374) may react explosively even in the absence of air.；· Disilane (UN3553) and Silane (UN2203) will ignite spontaneously in air and may re-ignite.；· Those substances designated with a (P) may polymerize explosively when heated or involved in a fire.；· Vapors from liquefied gas are initially heavier than air and spread along ground.；· Vapors may travel to source of ignition and flash back.；· Cylinders exposed to fire may vent and release flammable gas through pressure relief devices.；· Containers may explode when heated.；· Ruptured cylinders may rocket.

Extremely flammable. Gas/air mixtures are explosive.

Ignites in presence of heat or source of ignition.

Flammable, dangerous fire ... risk.

Inhalation of vapor causes slight intoxication, some shortness of breath. Liquid may cause frostbite of eyes or skin. (USCG, 1999)

· Vapors may cause dizziness or asphyxiation without warning, especially when in closed or confined areas.；· Some may be toxic if inhaled at high concentrations.；· Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite.；· Fire may produce irritating and/or toxic gases.

Like vinyl chloride, vinyl fluoride causes hepatic hemangiosarcoma in experimental animals. [HSDB] Inhalation of high concentrations can cause CNS depression; [ICSC] Vinyl fluoride, stabilized (UN1860) has warning of explosive polymerization; [ERG 2016]

1860 116P

1860 116P(inhibited)

Fluorinated Organic Compounds；Polymerizable Compounds

UN Hazard Class: 2.1

National Toxicology Program. Eleventh Report on Carcinogens (2005). The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. Vinyl Fluoride (875-02-5) is listed as reasonably anticipated to be a human carcinogen.[Available from, as of July 31, 2009: http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s188viny.pdf]

Kennedy GL; Crit Rev Toxicol 21 (2): 149-70 (1990). A review of the toxicology of fluorine containing monomers.

Evidence supporting the need for evaluating the toxicity of fluoroalkenes is discussed. Chemical properties, potential for worker exposure, and adequacy of information on oncogenicity, mutagenicity, teratogenicity, and other other effects are reviewed.[USEPA; Fluoroalkenes; Response to the Interagency Testing Committee; Fed Regist 46 (210): 53704-8 (1981)]

The U.S. high production volume (HPV) chemicals are those which are manufactured in or imported into the United States in amounts equal to or greater than one million pounds per year. Robust Summaries include health effects, ecotoxicity data, and environmental fate information for selected chemicals. EPA/Office of Pollution Prevention and Toxics; High Production Volume (HPV) Challenge Program's Robust Summaries and Test Plans. Available from: http://www.epa.gov/chemrtk/viewsrch.htm on Fluoroethylene as of November 3, 2004.

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Fluoroethene is included on this list.

Excerpt from ERG Guide 116 [Gases - Flammable (Unstable); polymerization hazard]:；DO NOT EXTINGUISH A LEAKING GAS FIRE UNLESS LEAK CAN BE STOPPED.；SMALL FIRE: Dry chemical or CO2.；LARGE FIRE: Water spray or fog. If it can be done safely, move undamaged containers away from the area around the fire.；FIRE INVOLVING TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not direct water at source of leak or safety devices; icing may occur. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Shut off supply; if not possible and no risk to surroundings, let the fire burn itself out. In other cases extinguish with powder, carbon dioxide. In case of fire: keep cylinder cool by spraying with water.

Fresh air, rest. Artificial respiration may be needed.

Rinse and then wash skin with water and soap. ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer immediately for medical attention.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.；· Keep unauthorized personnel away.；· Stay upwind, uphill and/or upstream.；· Many gases are heavier than air and will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.；· All equipment used when handling the product must be grounded.；· Stop leak if you can do it without risk.；· Do not touch or walk through spilled material.；· Do not direct water at spill or source of leak.；· Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material.；· If possible, turn leaking containers so that gas escapes rather than liquid.；· Prevent entry into waterways, sewers, basements or confined areas.；· Isolate area until gas has dispersed.

Excerpt from NIOSH Pocket Guide for Vinyl fluoride:；Eye: FROSTBITE - If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.；Skin: FROSTBITE - If frostbite has occurred, seek medical attention immediately; do NOT rub the affected areas or flush them with water. In order to prevent further tissue damage, do NOT attempt to remove frozen clothing from frostbitten areas. If frostbite has NOT occurred, immediately and thoroughly wash contaminated skin with soap and water.；Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible. (NIOSH, 2024)

General First Aid:；· Call 911 or emergency medical service.；· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.；· Move victim to fresh air if it can be done safely.；· Administer oxygen if breathing is difficult.；· If victim is not breathing:；-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.；-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).；-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.；· Remove and isolate contaminated clothing and shoes.；· For minor skin contact, avoid spreading material on unaffected skin.；· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.；· For severe burns, immediate medical attention is required.；· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.；· Keep victim calm and warm.；· Keep victim under observation.；· For further assistance, contact your local Poison Control Center.；· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.；Specific First Aid:；· In case of contact with liquefied gas, only medical personnel should attempt thawing frosted parts.

(General first aid procedures)；Eye: Frostbite - If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.；Skin: Frostbite - Compressed gases may create low temperatures when they expand rapidly. Leaks and uses that allow rapid expansion may cause a frostbite hazard. Wear appropriate personal protective clothing to prevent the skin from becoming frozen.；Breathing: Respiratory support

Fireproof. Separated from strong oxidants. Cool. Store only if stabilized.

Vapor is heavier than air and may travel considerable distance to a source of ignition and flash back.

· Wear positive pressure self-contained breathing apparatus (SCBA).；· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. /Vinyl fluoride, stabilized/

Evacuation: If fire becomes uncontrollable or container is exposed to direct flame - consider evacuation of one-half (1/2) mile radius. /Vinyl fluoride, stabilized/

In case of fire: Shut off supply; if not possible and no risk to surroundings, let the fire burn itself out; in other cases extinguish with powder, carbon dioxide. In case of fire: keep cylinder cool by spraying with water. ... NEVER direct water jet on liquid ...

Fireproof. Separated from strong oxidants. Cool. Store only if stabilized.

PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

Excerpt from ERG Guide 116 [Gases - Flammable (Unstable); polymerization hazard]:；ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Stop leak if you can do it without risk. Do not touch or walk through spilled material. Do not direct water at spill or source of leak. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Isolate area until gas has dispersed. (ERG, 2024)

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": ... Incineration may be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable for this purpose. The most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": HEPA (high-efficiency particulate arrestor) filters ... can be disposed of by incineration. For spent charcoal filters, the adsorbed material can be stripped off at high temp & carcinogenic wastes generated by this treatment conducted to & burned in an incinerator. ... LIQUID WASTE: ... Disposal should be carried out by incineration at temp that ... ensure complete combustion. SOLID WASTE: Carcasses of lab animals, cage litter & misc solid wastes ... should be disposed of by incineration at temp high enough to ensure destruction of chem carcinogens or their metabolites. /Chemical Carcinogens/

For more Disposal Methods (Complete) data for VINYL FLUORIDE (6 total), please visit the HSDB record page.

Vinyl fluoride was detected (concn not reported) in expired air collected from a control population of humans in a study of expired air constituents from diabetics(1).

central nervous system

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 24(SRC), determined from a structure estimation method(2), indicates that vinyl fluoride is expected to have very high mobility(SRC). Volatilization of vinyl fluoride from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 0.12 atm-cu m/mole(SRC), using a fragment constant estimation method(3). The potential for volatilization of vinyl fluoride from dry soil surfaces may exist(SRC) based upon an extrapolated vapor pressure of 1.98X10+4 mm Hg(4). Insufficient data are available to predict the relative importance or rate of biodegradation in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 24(SRC), determined from a structure estimation method(2), indicates that vinyl fluoride is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 0.12 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2 hrs and 3 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 2(SRC), from an estimated log Kow of 1.2(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Insufficient data are available to predict the relative importance or rate of biodegradation in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), vinyl fluoride, which has an extrapolated vapor pressure of 1.98X10+4 mm Hg at 25 °C(2), is expected to exist solely as a gas in the ambient atmosphere. Gas-phase vinyl fluoride is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 3 days(SRC), calculated from its rate constant of 5.56X10-12 cu cm/molecule-sec at 25 deg(3). Vinyl fluoride also reacts with ozone(4), which will contribute to its atmospheric degradation with an estimated half-life of about 16 days(SRC).

Neurotoxin - Acute solvent syndrome；Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.；IARC Carcinogen - Class 2: International Agency for Research on Cancer classifies chemicals as probable (2a), or possible (2b) human carcinogens.；NTP Carcinogen - Reasonably anticipated to be a human carcinogen.；ACGIH Carcinogen - Suspected Human.

The substance can be absorbed into the body by inhalation.

inhalation, skin and/or eye contact (liquid)

Headache. Dizziness. Confusion. Incoordination. Nausea. Vomiting. Shortness of breath.

ON CONTACT WITH LIQUID: FROSTBITE.

See Skin.

headache, dizziness, confusion, incoordination, narcosis, nausea, vomiting; liquid: frostbite

Environmental effects from the substance have not been investigated adequately.

PRECAUTIONS FOR "CARCINOGENS": Whenever medical surveillance is indicated, in particular when exposure to a carcinogen has occurred, ad hoc decisions should be taken concerning ... /cytogenetic and/or other/ tests that might become useful or mandatory. /Chemical Carcinogens/

Using a structure estimation method based on molecular connectivity indices(1), the Koc for vinyl fluoride can be estimated to be 24(SRC). According to a classification scheme(2), this estimated Koc value suggests that vinyl fluoride is expected to have very high mobility in soil.

The ability of fluoroethene to cause mutations at the gene locus coding for hypoxanthine-guanine phosphoribosyl transferase in Chinese hamster ovary cells (CHO/HPRT Assay) was evaluated in the presence and absence of metabolic activation from Aroclor induced rat liver S-9 fraction. Preliminary toxicity tests of nonactivated cultures treated with nominal concentrations of 0, 20, 40, 60, 80, and 100% fluoroethene gas produced a cloning efficiency in the range of 32.5-109% relative to the nitrogen gas control. Assays at the same nominal concentrations with metabolic activation produced cloning efficiency ranging from 76.2-179.8% relative to the nitrogen gas control. None of the nonactivated test cultures exhibited a significant increase in the mutant frequency compared to the negative control. Activated cultures exhibited a significant increase in the mutant frequency at all concentrations of fluoroethene tested.

It is not known whether vinyl fluoride occurs as a natural product(1).

/HUMAN EXPOSURE STUDIES/ /Investigators/ reported polyvinyl fluoride produced no skin reaction when /evaluated/ for irritation and sensitization on 215 human subjects. Contact with liquid vinyl fluoride may cause frost bite, and exposure to the vapor may cause headache or dizziness.

/SIGNS AND SYMPTOMS/ The vapor if inhaled will cause headache or dizziness. Liquid will cause frost bite /on contact/.

/OTHER TOXICITY INFORMATION/ In chronic fluoride poisoning of human beings it has been said that changes in the bones of the skull have sometimes led to optic atrophy through compression of the optic nerves, but no direct toxic effect on these nerves is known. /Fluorides/

Chemical: Ethene, fluoro-

Hazard Traits - Carcinogenicity；Authoritative List - IARC Carcinogens - 2A; NTP RoC - reasonable; Prop 65；Report - regardless of intended function of ingredient in the product

Ethene, fluoro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethene, fluoro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 30-01-2014 https://echa.europa.eu/registration-dossier/-/registered-dossier/10395

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Fluoroethene is included on this list.

Vinyl fluoride

1

10000

Flammable chemical that can be released at a facility.

Vinyl fluoride, vinyl bromide, fluroxene (2,2,2-trifluoroethyl vinyl ether), and acetylene alkylate the prosthetic heme group of cytochrome P-450 enzymes which catalyze their metabolism. The alkylated heme moiety has been identified in all four cases, after carboxyl group methylation and demetalation, as the dimethyl ether of N-(2-oxoethyl)protoporphyrin IX. ...The formation of the same prosthetic heme adduct with the four substrates requires introduction of an oxygen at the trifluoroethoxy or halide-substituted terminus of the pi bond and reaction of the unsubstituted terminus with a heme nitrogen atom.

...Vinyl halides induce etheno (epsilon) adducts that are identical to those formed after lipid peroxidation. Of these adducts, N2,3-ethenoguanine (epsilon G) is present in greatest amounts in tissues of exposed animals. After exposure to vinyl chloride for four weeks, epsilon G levels attain steady-state concentrations, such that the amount of newly formed adducts equals the number of adducts that are lost each day. ...Exposure to 10 ppm vinyl chloride for five days caused a two- to threefold increase in epsilon G over that of the controls, while four weeks' exposure resulted in a fivefold increase. ...Exposure to 100 ppm vinyl chloride for four weeks caused a 25-fold increase in epsilon G levels over that found in control rats, while exposure to 1100 ppm resulted in a 42-fold increase. The amount of endogenous epsilon G was similar in liver DNA from rats and humans. A comparable response to exposure was seen in rats and mice exposed to 0, 25, 250 or 2500 ppm vinyl fluoride for 12 months. There was a very high correlation between epsilon G levels in rat and mouse liver at 12 months and the incidence of hemangiosarcoma at two years. ...The expression of N-methylpurine-DNA glycosylase mRNA was induced in rat liver after exposure to either 25 or 2500 ppm vinyl fluoride.

The first step in the metabolism of ... vinyl fluoride ... has been proposed to involve microsomal oxidation leading to epoxide formation across the double bond. /It has been/ suggested that the resulting oxiranes are highly reactive and therefore can covalently bind to nucleic acids with the eventual end result of mutations and cancer.

Increased exhalation of acetone has been reported to be due to the effects of vinyl fluoride on intermediary metabolism. Intermediate metabolites of vinyl fluoride have been shown to alkylate the heme group of cytochrome P450 enzymes in vitro, suggesting potential inhibition of the metabolism of other substances.

Metabolism, measured by the decline of fluoride in the inhalation chamber, was dose-dependant and saturated after exposure of rats to concentrations greater than 75 ppm. Fluoride ion has been shown to be released from vinyl fluoride oxidative metabolism and released into the urine following acute exposures.

Based on the structural similarity to both vinyl chloride and vinyl bromide, the metabolism of vinyl fluoride is expected to involve microsomal oxidation leading to epoxide formation across the double bond, followed by rearrangement to form the 2-halo(fluoro)acetaldehyde. Both the epoxide and the acetaldehyde are capable of binding to tissue nucleophiles.

For more Metabolism/Metabolites (Complete) data for VINYL FLUORIDE (7 total), please visit the HSDB record page.

Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.

Rats were exposed in closed inhalation system to levels of halogenated ethylenes. Cmpd with low boiling point were enriched in tissues much less than those with higher boiling point. Metabolic elimination of halogenated ethylenes was saturable, dose-dependent process.

Simple fluoroalkenes are probably biodegradable, demonstrated by increased urinary excretion of free fluoride ion following exposure.

Vinyl fluoride is readily absorbed after its inhalation and reaches a tissue concentration in rats that is 90% of that in the inhaled air.

Used to produce polyvinyl fluoride, a polymer noted for its strength and weather resistance; [Hawley]

The main use of monofluoroethylene is in the production of poly(vinyl fluoride).

As chemical intermediate

2023: 10,000,000 - <50,000,000 lb；2022: 10,000,000 - <50,000,000 lb；2021: 10,000,000 - <50,000,000 lb；2020: 10,000,000 - <50,000,000 lb

Ethene, fluoro- is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and/or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B; 51FR21438).

(1975) APPROX 1.5X10+9 GRAMS

ESSENTIALLY 100% FOR POLYVINYL FLUORIDE PRODUCTION (1975)

Intermediate

... With mercury catalysts, vinyl fluoride can be produced directly from acetylene and hydrogen fluoride.

... First prepared by reaction of 1,1-difluoro-2-bromoethane with zinc.

The dehydrochlorination of 1-chloro-1-fluoroethane ... and 1-chloro-2-fluoroethane are ... utilized commercially

Grades or purity: 99.9+%

Industrial Gas Manufacturing

Ethene, fluoro-: ACTIVE

Inhibitor of polymerization: terpene b 0.2%