HCID6420138

Cyc-116

4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine

C18H20N6OS368.5 g/molCAS 693228-63-6

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IDENTITY

结构与身份

标准SMILES: Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1
InChIKey: GPSZYOIFQZPWEJ-UHFFFAOYSA-N
分子式: C18H20N6OS
平均分子量: 368.5 g/mol
单同位素质量: 368.14193046

COMPUTED

结构计算性质

已同步

XLogP: 2.6
极性表面积: 117 Å²
氢键供体: 2
氢键受体: 8
可旋转键: 4
重原子: 26
形式电荷: 0
复杂度: 443

PHARMACOLOGY

药理信息

来源：PubChem

Protein Binding

CYC116, an orally-available inhibitor of Aurora kinases A and B, and VEGFR2, in patients with advanced solid tumors.

Mechanism of Action

Aurora kinases are enzymes that help dividing cells share their materials between two daughter cells. In many people with cancer Aurora kinase malfunctions and normal control of cell division is lost resulting in abnormal growth. CYC116 inhibits Aurora kinase may slow down the growth of cancer cells and lead to their death by apoptosis.

ALIASES

名称与别名

共 67 条

693228-63-6CYC-116CYC116CYC 116YAX4981K2DRefChem:5801704-methyl-5-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)thiazol-2-amine4-methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amineCHEMBL4829674-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amineMFCD141558052-Pyrimidinamine,4-(2-amino-4-methyl-5-thiazolyl)-N-[4-(4-morpholinyl)phenyl]-4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amineKinome_6362uue2-PYRIMIDINAMINE, 4-(2-AMINO-4-METHYL-5-THIAZOLYL)-N-(4-(4-MORPHOLINYL)PHENYL)-2-Pyrimidinamine, 4-(2-amino-4-methyl-5-thiazolyl)-N-[4-(4-morpholinyl)phenyl]-GPSZYOIFQZPWEJ-UHFFFAOYSA-N4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin-4-yl)phenyl]pyrimidin-2-amine2c5t

REACTIONS

参与反应

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