Piperazine Adipate
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Basic information
- CAS
142-88-1- Standard SMILES
C1CNCCN1.O=C(O)CCCCC(=O)O- InChIKey
BVEGEKOBSPXUJS-UHFFFAOYSA-N- Molecular formula
- C6H10O4.C4H10N2
- Average molar mass
- 232.28 g/mol
- Monoisotopic mass
- 232.14230712
Overview
Piperazine adipate appears as odorless white crystalline powder or solid. Slightly acid taste. Melting point 256-257 °C. Dissolves slowly. pH (0.2-0.01 molar aqueous solutions) 5.45. pH (5% solution) 5 - 6. (NTP, 1992)
Names & identifiers
- Preferred name
- Piperazine Adipate
- IUPAC
- hexanedioic acid;piperazine
- English name
- PIPERAZINE ADIPATE
- Molecular formula
- C10H20N2O4
- Molecular weight
- 232.28
Names & synonyms
Piperazine adipate142-88-1AdiprazinaAdiprazineVermicomprenArduverminHelmirazinPiperascatPiperaskatDietelminNometanOxurasin
Show more names
entacyloxyzin(tabl.)vermicompren(tabl.)
OxypaatPipadoxVermilasshexanedioic acid;piperazinepiperazinium adipatePiperazine adipinateV7P5P122LBNSC-74383
Database identifiers
- CAS
142-88-1- PubChem CID
- 8905
- DTXSID
DTXSID2059724- ChEMBL
CHEMBL3276110- ChEBI
CHEBI:133924- UNII
- V7P5P122LB
- EC Number
- 205-569-0
Properties
Computed structural propertiesFilling in
- Topological polar surface area
- 98.7 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 5
- Heavy atoms
- 16
- Formal charge
- 0
- Complexity
- 140
Experimental & physicochemical properties
Solubility10 to 50 mg/mL at 63 °F (NTP, 1992)
Melting Point482 °F approximately with decomposition (NTP, 1992)
Physical DescriptionPiperazine adipate appears as odorless white crystalline powder or solid. Slightly acid taste. Melting point 256-257 °C. Dissolves slowly. pH (0.2-0.01 molar aqueous solutions) 5.45. pH (5% solution) 5 - 6. (NTP, 1992)
Physicochemical properties
- Melting point
- 256 · 256-257°
- Boiling point
- 374.44 °C · 374.44°C (rough estimate)
- Density
- 1.1633 · 1.1633 (rough estimate)
- vapor pressure
- 2.8 hPa · 2.8hPa
- refractive index
- 1.471 · 1.4710 (estimate)
- storage temp.
- -20 °C · Store at -20°C
- solubility
- 571.42 mg/L · 571.42mg/L in organic solvents at 20 ℃
- form
- Solid
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 25% (1 of 4) of reports.
Danger
H314 (50%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
P233, P260, P261, P264, P264+P265, P271, P272, P273, P280, P284, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P319, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P363, P403, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 4 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Danger
Hazard information
Regulatory Information
Chemical: Hexanedioic acid, compound with piperazine (1:1)
REACH registered substance: Piperazine adipate (EC: 205-569-0)
Piperazine adipate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety InformationIMAP assessments - Piperazine salts: Human health tier II assessment
Fire HazardsFlash point data for this chemical are not available; however it is probably combustible. (NTP, 1992)
Health HazardsSYMPTOMS: Symptoms of prolonged exposure to this chemical include dizziness, vomiting, blurred vision, muscular incoordination and paresthesia.
Reactive GroupSalts, Acidic
Reactivity ProfilePIPERAZINE ADIPATE gives weakly acidic aqueous solutions. Can serve as both an oxidizing agent and as a reducing agent.
Chemistry & industry
Uses & manufacturing
General Manufacturing InformationHexanedioic acid, compd. with piperazine (1:1): INACTIVE
Applications
UsesIt is used as an anthelmintic for humans and farm animals against intestinal roundworms and pinworms infection
UsesPiperazine Adipate is used as an anthelmintic agent. Derivatives of piperazine are widely used in the pharmaceutical, biomedical and chemical fields. Piperazine derivatives are known to have high antiserotonin potency, antimicrobial activity, and potential anticancer activity in humans.
General DescriptionOdorless white crystalline powder or solid. Slightly acid taste. Melting point 256-257°C. Dissolves slowly. pH (0.2-0.01 molar aqueous solutions) 5.45. pH (5% solution) 5 - 6.
Additional notes
DefinitionChEBI: Piperazine adipate is a piperazinium salt obtained by combining equimolar amounts of piperazine and adipic acid. It has a role as an anthelminthic drug and an antinematodal drug. It contains an adipate(2-) and a piperazinium(2+).
Related reactions
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Compound notes
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