uspto-grants-1986_09 · 10.6084/m9.figshare.5104873.v1 · US04610992
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IDENTITY
结构与身份
- 标准SMILES
- CC1(C)Oc2ccc(C#N)cc2[C@@H](N2CCCC2=O)[C@@H]1O
- InChIKey
- TVZCRIROJQEVOT-CABCVRRESA-N
- 分子式
- C16H18N2O3
- 平均分子量
- 286.33 g/mol
- 单同位素质量
- 286.13174244
COMPUTED
结构计算性质
- XLogP
- 0.8
- 极性表面积
- 73.6 Ų
- 氢键供体
- 1
- 氢键受体
- 4
- 可旋转键
- 1
- 重原子
- 21
- 形式电荷
- 0
- 复杂度
- 481
PHARMACOLOGY
药理信息
MeSH Pharmacological Classification
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS.
Drugs used to cause dilation of the blood vessels.
ALIASES
名称与别名
Levcromakalim94535-50-9(-)-CromakalimBRL-38227DTXSID5045677RW7PN4BLDJ2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3S,trans)-(3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chromane-6-carbonitrileDTXCID3025677levcromakalimumBRL38227RefChem:924700LemakalimBRL 38227BRL 34915CHEMBL100MLS000069770(3S,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-6-chromancarbonitrile(3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,4-dihydrochromene-6-carbonitrile(+/-)-cromakalim
REACTIONS
相关反应
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