1-[3-[[(2,5-Dioxopyrrolidinyl)oxy]carbonyl]phenyl]-1H-pyrrol-2,5-dion
m-Maleimidobenzoyl-N-hydroxysuccinimide
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Grundinformationen
- CAS
58626-38-3- Standard-SMILES
O=C(ON1C(=O)CCC1=O)c1cccc(N2C(=O)C=CC2=O)c1- InChIKey
LLXVXPPXELIDGQ-UHFFFAOYSA-N- Summenformel
- C15H10N2O6
- Durchschnittliche Molmasse
- 314,25 g/mol
- Monoisotopische Masse
- 314,05388604
Überblick
coupling reagent; RN given refers to parent cpd
Namen und Bezeichner
- Bevorzugter Name
- m-Maleimidobenzoyl-N-hydroxysuccinimide
- IUPAC
- (2,5-dioxopyrrolidin-1-yl) 3-(2,5-dioxopyrrol-1-yl)benzoate
- Lokaler Name
- 1-[3-[[(2,5-Dioxopyrrolidinyl)oxy]carbonyl]phenyl]-1H-pyrrol-2,5-dion
- Englischer Name
- 3-Maleimidobenzoic acid N-hydroxysuccinimide ester
- Summenformel
- C15H10N2O6
- Molmasse
- 314.25
Namen und Synonyme
58626-38-33-Maleimidobenzoyl N-hydroxysuccinimideDTXSID00207335N-(m-maleimidobenzoyloxy)succinimidem-maleimidobenzoyl-n-hydroxysuccinimideRefChem:422980DTXCID00129826n-succinimidyl m-maleimidobenzoatemeta-maleimidobenzoyl N-hydroxysuccinimide3-maleimidobenzoyl N-hydroxysuccinimide esterm-maleimidobenzoic acid n-hydroxysuccinimide ester261-368-8
Weitere Namen anzeigen
MBSM-MALEIMIDOBENZOYL-N-HYDROXYSUCCINIMIDE ESTER3-(Male(MBS-1)NSC 294786MBS CrosslinkerEinecs 261-368-8MBS protein crosslinker
3-Maleimidobenzoic acid N-hydroxysuccinimide esterN-Succinimidyl 3-Maleimidobenzoate3-Maleimido-benzoic acid-OSuMFCD000055142,5-dioxopyrrolidin-1-yl 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate(2,5-dioxopyrrolidin-1-yl) 3-(2,5-dioxopyrrol-1-yl)benzoate3-N-Maleimidobenzoic Acid N-Succinimidyl Ester1-(3-(((2,5-Dioxopyrrolidinyl)oxy)carbonyl)phenyl)-1H-pyrrole-2,5-dione
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- 0
- Polarare Oberfläche (TPSA)
- 101 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 23
- Formalladung
- 0
- Komplexität
- 591
Experimentelle und physikochemische Eigenschaften
Chemical ClassesNitrogen Compounds -> Succinimides
Physical DescriptionBeige powder; [Sigma-Aldrich MSDS]
Physikochemische Eigenschaften
- Schmelzpunkt
- 175 · 175-177 °C(lit.)
- Siedepunkt
- 524.5 · 524.5±52.0 °C(Predicted)
- Dichte
- 1.59 · 1.59±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · -20°C
- Löslichkeit
- 20 mg/mL · ethyl acetate or DMF: ≤20 mg/mL may require addition of solvent to coupling buffer to at least 5% to maintain solubility
- Aggregatzustand
- crystalline
- pka
- -2.63 · -2.63±0.20(Predicted)
- Farbe
- White to Almost white
- BRN
- 1505254 · 1505254
- InChI
- 1S/C15H10N2O6/c18-11-4-5-12(19)16(11)10-3-1-2-9(8-10)15(22)23-17-13(20)6-7-14(17)21/h1-5,8H,6-7H2
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 41 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazards SummaryAn irritant; [Sigma-Aldrich MSDS]
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
Sicherheitsdaten
- F
- 10-21
- wgk
- 3
- hs_code
- 29280000
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26-36
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
Verwendung und Herstellung
UsesCoupling reagent. [ChemIDplus]
Anwendungen
Verwenden3-Maleimidobenzoic acid N-hydroxysuccinimide ester is a heterobifunctional coupling reagent useful for forming enzyme immunoconjugates. The reactive groups are the NHS ester and maeimide.
Zugehörige Reaktionen
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