Venturicidin
Venturicidin · AaboMycin A2 · 4,21-Dioxabicyclo[15.3.1]heneicosa-9,15,18-trien-3-one, 11-[(2,6-dideoxy-β-D-arabino-hexopyranosyl)oxy]-1-hydroxy-5-[(1R,3R,4S,5S)-4-hydroxy-1,3,5-trimethyl-6-oxooctyl]-6,8,16,18-tetramethyl-, (1R,5S,6R,8R,9E,11R,15E,17R)- · (1R,2E,7R,8E,10R,12R,13S,17R)-7-[(2R,4R,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-17-hydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4,6-dimethyl-7-oxononan-2-yl]-2,10,12,20-tetramethyl-14,21-dioxabicyclo[15.3.1]henicosa-2,8,19-trien-15-one
Identifikatoren & physikalische Daten
| CAS No. | 33538-72-6 |
|---|---|
| Summenformel | C40H66O10 |
| Durchschnittliche Molmasse | 706,95 g/mol |
| SMILES | CCC(=O)[C@@H](C)[C@@H](O)[C@H](C)C[C@@H](C)[C@H]1OC(=O)C[C@@]2(O)CC=C(C)[C@H](O2)/C(C)=C/CCC[C@@H](O[C@H]2C[C@@H](O)[C@H](O)[C@@H](C)O2)/C=C/[C@H](C)C[C@H]1C |
| InChIKey | VIOYQVOQUWWSAB-KEXSXYLYSA-N |
| PubChem CID | 10032713 |
| ChEBI | CHEBI:224229 |
Chemische & physikalische Eigenschaften
| Schmelzpunkt | 168-170°mp 145-149° (ethyl acetate-petr ether) |
|---|---|
| Siedepunkt | 823.4±65.0 °C(Predicted) |
| Dichte | 1.14±0.1 g/cm3(Predicted) |
| Löslichkeit | DMF: SolubleDMSO: SolubleEthanol: SolubleMethanol: Soluble |
| pKa (Säurekonstante) | 11.80±0.70(Predicted) |
| Aggregatzustand | White to off-white solid. |
Anwendungen & Verwendung
Beschreibung
Venturicidin B is a macrolide bacterial metabolite that has been found in Streptomyces.
Verwenden
The macrolide antibiotic Venturicidin B, isolated from a Streptomyces sp., is a potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector. Venturicidin A was originally isolated as an antifungal agent.