96892-57-8NS(=O)(=O)OCCCCCCCOS(N)(=O)=OGOJJWDOZNKBUSR-UHFFFAOYSA-NHepsulfam is a bisulfamic ester which is similar in structure to busulfan and belongs to the family of drugs known as alkylsulfonate alkylating agents. Hepsulfam forms covalent linkages with nucleophilic centers in DNA, resulting in depurination, base miscoding, strand scission, DNA-DNA and DNA-protein cross-linking, and cytotoxicity. (NCI04)
96892-57-8DTXSID90242619CHEMBL182440Water 3.6 - 2.7 (mg/mL)
Buffer, pH 4 5.0 - 3.3 (mg/mL)
Buffer, pH 9 5.6 - 3.7 (mg/mL)
Ethanol > 10.6 (mg/mL)
Dimethylacetamide > 10.0 (mg/mL)
DMSO > 11.2 (mg/mL)
Bulk: Test samples exposed to room temperature (25 °C) for three months shows very little degradation. Test samples stored at 50 °C in the dark showed significantly greater loss (g. 10 %). Solution: A test sample of 25 mg/mL in 30% DMSO /water showed no significant degradation when stored for 48 hr.
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
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