enniatin A
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Grundinformationen
- CAS
2503-13-1- Standard-SMILES
CC[C@@H](C)[C@H]1C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)C(=O)O[C@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)C(=O)OC(C(C)C)C(=O)N1C- Summenformel
- C36H63N3O9
- Durchschnittliche Molmasse
- 681,9 g/mol
Namen und Bezeichner
- Bevorzugter Name
- enniatin A
- Englischer Name
- enniatin A
- Summenformel
- C36H63N3O9
- Molmasse
- 681.9
Namen und Synonyme
enniatin ALateritin IU-[13C]-Enniatin AN-Methylcyclo(L-Ile-D-Hmb-N-methyl-L-Ile-D-Hmb-N-methyl-L-Ile-D-Hmb-)(3S,6R,9S,12R,15S,18R)-3,9,15-tris[(2S)-butan-2-yl]-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexoneCyclo[(2R)- 2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl- N-methyl-L- isoleucyl]
Datenbank-Bezeichner
- CAS
2503-13-1- PubChem CID
- 101289749
- EC Number
- 695-563-8
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 122 · 122-124 °C
- Siedepunkt
- 847.4 · 847.4±65.0 °C(Predicted)
- Dichte
- 1.022 · 1.022±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · -20°C
- Löslichkeit
- 10 mg/mL · DMSO: soluble10mg/mL
- Aggregatzustand
- White to off-white crystalline solid.
- pka
- -0.96 · -0.96±0.70(Predicted)
- Biologische Quelle
- Gnomonia errabunda
- InChIKey
- TWHBYJSVDCWICV-BHZTXFQCSA-N
- SMILES
- N1([C@H](C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C1=O)C(C)C)[C@H](CC)C)C)C(C)C)[C@H](CC)C)C)C(C)C)[C@H](CC)C)C
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- ridadr
- 2811
- hs_code
- 2934999090
- risk_code
- 23/24/25
- hazard_code
- T
- safety_code
- 45
- hazard_class
- 6.1(a)
- packing_group
- I
- Speicherklasse
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- Hazard Classifications
- Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 3 Oral
Chemie und Industrie
Anwendungen
BeschreibungEnniatins are cyclohexadepsipeptides commonly isolated from fungi that are known to have antibiotic properties and to induce apoptosis in several cancer lines. Many function as ionophores, forming pores in cellular membranes to allow selective ion transport. Enniatin A is one of four major analogs in the enniatin complex . It has been shown to moderately inhibit acyl-CoA:cholesterol acyltranferase activity in rat liver microsomes with an IC50 value of 22 μM. Enniatin A also demonstrates anthelmintic properties against N. brasiliensis, T. spiralis, and H. spumosa.
VerwendenEnniatins are a family of depsipeptide ionophores, produced by several Fusarium species. More recently, the effects of the enniatins on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumour action have received more focus. Enniatin A is one of four major analogues of the enniatin complex and has not previously been available for investigation.
Ergänzende Hinweise
DefinitionChEBI: An enniatin obtained from formal cyclocondensation of three N-[(2R)-2-hydroxy-3-methylbutanoyl]-N-methyl-L-isoleucine units.
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