HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Oxycinchophen
Oxinofen · Fenidrone · Chinoxone · Sintofene · Magnofenyl · Reumartril · Magnophenyl · oxycinchophen
Identifikatoren & physikalische Daten
| CAS No. | 485-89-2 |
|---|---|
| Summenformel | C16H11NO3 |
| Durchschnittliche Molmasse | 265,26 g/mol |
| Monoisotopische Masse | 265,07389321 g/mol |
| SMILES | O=C(O)c1c(O)c(-c2ccccc2)nc2ccccc12 |
| InChIKey | XAPRFLSJBSXESP-UHFFFAOYSA-N |
| PubChem CID | 10239 |
| ChEMBL | CHEMBL219376 |
| ChEBI | CHEBI:135094 |
| EC No. | 207-624-4 |
| DTXSID | DTXSID0057750 |
| Lokaler Name | Oxycinchophen |
Chemische & physikalische Eigenschaften
| XLogP | 3,6 |
|---|---|
| Polarare Oberfläche (TPSA) | 70,4 |
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 2 |
| Schwere Atome | 20 |
| Formalladung | 0 |
| Komplexität | 354 |
| Schmelzpunkt | 206.5°C (rough estimate) |
| Siedepunkt | 408.48°C (rough estimate) |
| Dichte | 1.1861 (rough estimate) |
| Brechungsindex | 1.5300 (estimate) |
| Lagerbedingungen | 2-8°C |
| pKa (Säurekonstante) | 0.55±0.10(Predicted) |
| Farbe | Minute, deep yellow prisms from alc |
Sicherheit & Vorschriften
| Toxizität | LD50 orl-dog: >5 mg/kg PEMNDP 9,643,91 |
|---|
Anwendungen & Verwendung
Verwenden
Oxicinchophen has bene used to study P-selectin antagonistic activity, DHOD inhibitory activity, SAR of quinoline salicylic acids using Pfitzinger reaction of isatin derivatives with (acetyloxy)acetophenone derivatives; effect of antiinflammatory drugs on vascular smooth muscle; increase in oxygen consumption in the absence of a phosphate acceptor and to inhibit ATP synthesis in the isolated rat liver mitochondria.