Thioetheramide PC
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Grundinformationen
- CAS
116457-99-9- Standard-SMILES
CCCCCCCCCCCCCCCCSC[C@H](COP(=O)(O)OCC[N+](C)(C)C)NC(=O)CCCCCCCCCCCCCCC- InChIKey
WLWWVTPUDQTUJU-KDXMTYKHSA-O- Summenformel
- C40H84N2O5PS+
- Durchschnittliche Molmasse
- 736,162 g/mol
- Monoisotopische Masse
- 735,58330784
Namen und Bezeichner
- Bevorzugter Name
- Thioetheramide PC
- IUPAC
- (7S)-7-[(Hexadecylsulfanyl)methyl]-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-3,5-dioxa-8-aza-4lambda~5~-phosphatetracosan-1-aminium
- Englischer Name
- 1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE
- Summenformel
- C45H93N2O4PS
- Molmasse
- 789.27
Namen und Synonyme
THIOETHERAMIDE PCWLWWVTPUDQTUJU-KDXMTYKHSA-NThioetheramide phosphorylcholine1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE1-PALMITYLTHIO-2-PALMITOYLAMINO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE1,2-DIDEOXY-1-(S-HEXADECYL)THIO-2-(N-HEXADECANOYL)AMINO-SN-GLYCERYL-3-PHOSPHORYLCHOLINE3,5-Dioxa-9-thia-4-phosphapentacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-7-[(1-oxohexadecyl)amino]-, inner salt, 4-oxide, (7S)-
Datenbank-Bezeichner
- CAS
116457-99-9- PubChem CID
- 10259407
- DTXSID
DTXSID60437378- Nikkaji
- J562.285I
Eigenschaften
Physikochemische Eigenschaften
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- Soluble in DMSO;Soluble in dimethyl formamide
- Aggregatzustand
- White solid.
Chemie und Industrie
Anwendungen
BeschreibungThioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2). The IC50 value for thioetheramide-PC is 2 μM at a substrate concentration of 0.5 mM. In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.
Anbieter10 Anbieter
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
上海阿拉丁生化科技股份有限公司6206333 13167063860 · [email protected]
BOC Sciences16314854226 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
上海源叶生物科技有限公司18916372613 · [email protected]
Aladdin Scientific[email protected]
ChemeGen 中国18818260767 · [email protected]
上海甄准生物科技有限公司18019219489 18901678489 · [email protected]
广州优南科技有限公司020-82000279 18988941452 · [email protected]
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