Xenon Xe-129
Grundinformationen
- CAS
13965-99-6- Standard-SMILES
[129Xe]- InChIKey
FHNFHKCVQCLJFQ-YPZZEJLDSA-N- Summenformel
- Xe
- Durchschnittliche Molmasse
- 128,9048 g/mol
- Monoisotopische Masse
- 128,90478086
Überblick
Xenon-129 atom is the stable isotope of xenon with relative atomic mass 128.904780, 26.4 atom percent natural abundance and nuclear spin 1/2. It is a xenon(0) and a xenon atom.
Namen und Bezeichner
- Bevorzugter Name
- Xenon Xe-129
- IUPAC
- xenon-129
- Englischer Name
- XENON (129XE)
- Summenformel
- Xe
- Molmasse
- 128.9
Namen und Synonyme
Xenon Xe-129XENOVIEWXenon, isotope of mass 129129XeXe 1299C7571UDT5Xenon xe-129 hyperpolarizedXenon xe-129mXenon, xe-129mRefChem:902350xenon-12913965-99-6
Weitere Namen anzeigen
Xe-129XENON (129XE)XENON (129XE, 99%)Xenon-129 (Xe-129)
UNII-9C7571UDT5726Q6M95ZAHp 129xeUNII-726Q6M95ZAXenon xe-129, hyperpolarizedXenon-129 isotopeXenon-129Xe129mXe isotope
Datenbank-Bezeichner
- CAS
13965-99-6- PubChem CID
- 10290811
- DTXSID
DTXSID401028031- ChEMBL
CHEMBL4594411- ChEBI
CHEBI:52453- UNII
- 726Q6M95ZA、9C7571UDT5
- EC Number
- 630-791-3
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 0 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 0
- Frei drehbare Bindungen
- 0
- Schwere Atome
- 1
- Formalladung
- 0
- Komplexität
- 0
Experimentelle und physikochemische Eigenschaften
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physikochemische Eigenschaften
- Siedepunkt
- -107.1 °C · -107.1°C (lit.)
- Aggregatzustand
- gas
- InChI
- 1S/Xe/i1-2
- InChIKey
- FHNFHKCVQCLJFQ-YPZZEJLDSA-N
- SMILES
- [129Xe]
- CAS Number Unlabeled
- 7440 · 7440-63-3
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H280 (100%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]
P410+P403</a, and a href="https://pubchem.ncbi.nlm.nih.gov/ghs/#P410+P403">P410+P403 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
DOT Hazard Classification
Xenon-129m
Radioactive material
Atomic number: 54
Hazard Classes and CategoriesPress. Gas (Liq.) (100%)
Sicherheitsdaten
- wgk
- WGK 3
- Speicherklasse
- 2A - Gases
- Hazard Classifications
- Press. Gas Liquefied gas
Chemie und Industrie
Pharmakologische Informationen
Protein BindingNot available.
Pharmacodynamics
The volume of gas inhaled, the degree of xenon-129 isotopic enrichment, and the degree of hyperpolarization affect the MRI signal obtained with hyperpolarized xenon-129. When inhaled for long periods of time, xenon acts as an anesthetic at concentrations higher than 50%. Xenon has also been used in computerized tomography (CT) scans to measure cerebral blood flow.
Mechanism of Action
The nuclear polarisation of xenon-129 (Xe-129) is increased up to five orders of magnitude in a process called hyperpolarization. This process compensates for the low density of gas compared to that of solid tissue. After being inhaled, hyperpolarized xenon-129 (Xe-129) is distributed throughout the ventilated lung. Lung ventilation can be visualized using a multi-nuclear capable magnetic resonance imaging (MRI) scanner with a Xe-129 MRI coil.
Biological Half-LifeXenon-129 in a 75% Xe/25% N<sub>2</sub> gas mixture has an elimination half-life of 14.5 seconds. In a 25% Xe/75% N2 gas mixture, xenon-129 has an elimination half-life of 14.3 seconds.
Metabolism/MetabolitesAs an inert gas, xenon is not metabolized under normal conditions. It does not have an effect on renal or hepatic function.
FDA Pharmacological Classification
726Q6M95ZA
XENON XE-129, HYPERPOLARIZED
Established Pharmacologic Class [EPC] - Hyperpolarized Contrast Agent
Mechanisms of Action [MoA] - Magnetic Resonance Contrast Activity
Xenon xe-129, hyperpolarized is a Hyperpolarized Contrast Agent. The mechanism of action of xenon xe-129, hyperpolarized is as a Magnetic Resonance Contrast Activity.
XENON XE 129 HYPERPOLARIZED
Absorption, Distribution and Excretion
The pharmacokinetic parameters of hyperpolarized xenon-129 are similar to those of non-polarized xenon. Xenon has low solubility; however, it is higher in fatty tissues compared to aqueous tissues and body compartments such as plasma. A study that modelled the pharmacokinetics of hyperpolarized xenon-129 suggests that 80% is the maximum concentration that can be inhaled. Hyperpolarized xenon-129 delivered through inhalation can be detected in both pulmonary and cerebral tissues.
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