Grundinformationen
- CAS
52558-73-3- Standard-SMILES
CCCCCCCCCCCCCC(=O)N(C)CC(=O)O- InChIKey
NGOZDSMNMIRDFP-UHFFFAOYSA-N- Summenformel
- C17H33NO3
- Durchschnittliche Molmasse
- 299,4 g/mol
- Monoisotopische Masse
- 299,24604391
Überblick
The CIR Expert Panel concluded that the following ingredients are safe as used in cosmetics when formulated to be non-irritating. The Expert Panel cautions that these ingredients should not be used in cosmetic products in which N-nitroso compounds can be found...Myristoyl Sarcosine...
Namen und Bezeichner
- Bevorzugter Name
- Myristoyl Sarcosine
- IUPAC
- 2-[methyl(tetradecanoyl)amino]acetic acid
- Lokaler Name
- N-(1-Oxotetradecyl)sarkosin
- Englischer Name
- N-(1-oxotetradecyl)sarcosine
- Summenformel
- C17H33NO3
- Molmasse
- 299.45
Namen und Synonyme
52558-73-3Myristoyl sarcosineN-(1-Oxotetradecyl)sarcosineHamposyl mGlycine, N-methyl-N-(1-oxotetradecyl)-N-Myristoylsarcosine acidn-tetradecanoylsarcosinemyristoyl sarcosinateZL6OI6P595CRODASINIC MMyristoyl N-methylglycineEINECS 258-007-1
Weitere Namen anzeigen
N-MyristoylsarcosineN-Methyl-N-myristoylglycineN-(1-Oxotetradecyl)sarkosinN-Tetradecanoyl-N-methylglycine
SARCOSINE, N-MYRISTOYL-DTXSID7068766N-Methyl-N-(1-oxotetradecyl)glycineRefChem:819747DTXCID6041210MYRISTOYL SARCOSINE [INCI]n-methyl-n-tetradecanoylglycine2-[methyl(tetradecanoyl)amino]acetic acid
Datenbank-Bezeichner
- CAS
52558-73-3- PubChem CID
- 104234
- DTXSID
DTXSID7068766- ChEMBL
CHEMBL4462773- UNII
- ZL6OI6P595
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 5,6
- Polarare Oberfläche (TPSA)
- 57,6 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 3
- Frei drehbare Bindungen
- 14
- Schwere Atome
- 21
- Formalladung
- 0
- Komplexität
- 279
Experimentelle und physikochemische Eigenschaften
Cosmetics
Cosmetic ingredients (Myristoyl Sarcosine) -> CIR (Cosmetic Ingredient Review)
Cleansing; Surfactant; Hair conditioning; Antistatic
Physikochemische Eigenschaften
- Siedepunkt
- 439.5 · 439.5±28.0 °C(Predicted)
- Dichte
- 0.971 · 0.971±0.06 g/cm3(Predicted)
- Dampfdruck
- 0.174 Pa · 0.174Pa at 25℃
- pka
- 3.96 · 3.96[at 20 ℃]
- Wasserlöslichkeit
- 900 mg/L · 900mg/L at 25℃
- Kosmetik-Inhaltsstoffe Funktionen
- SURFACTANT - CLEANSINGANTISTATICHAIR CONDITIONINGCLEANSING
- LogP
- 5.256 · 5.256 (est)
- EPA chemische Informationen
- Glycine, N-methyl-N-(1-oxotetradecyl)- (52558-73-3)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H314 (98.3%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
P260, P264, P264+P265, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 59 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
Chemical: Glycine, N-methyl-N-(1-oxotetradecyl)-
REACH registered substance: N-(1-oxotetradecyl)sarcosine (EC: 258-007-1)
Glycine, N-methyl-N-(1-oxotetradecyl)-: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesSkin Corr. 1C (98.3%)
Toxikologische Informationen
Health EffectsAcyl sarcosines may cause irritation to the skin and eyes. They may also react to produce N-nitrososarcosine, which is believed to be carcinogenic. (A2881)
Exposure RoutesOral (A2881) ; inhalation (A2881) ; dermal (A2881)
Toxicity Summary
The CIR Expert Panel concluded that the following ingredients are safe as used in cosmetics when formulated to be non-irritating. The Expert Panel cautions that these ingredients should not be used in cosmetic products in which N-nitroso compounds can be found...Myristoyl Sarcosine...
Chemie und Industrie
Pharmakologische Informationen
Metabolism/Metabolites
Acyl sarcosines can be absorbed following oral or dermal contact, while nitrosamines can enter the body via ingestion, inhalation, or dermal contact. Once in the body, nitrosamines are metabolized by cytochrome P-450 enzymes, which essentially activates them into carcinogens. Sarcosine is metabolized to glycine by the enzyme sarcosine dehydrogenase. (A2878, A2879, L1892)
Verwendung und Herstellung
Uses
CIR ingredient: Myristoyl Sarcosine
Acyl sarcosines are used as hair-conditioning agents and surfactant-cleansing agents in cosmetics, as well as to improve wetting and penetration of topical pharmaceutical products. Acyl sarcosines and their sodium salts are also used in the metal finishing and processing industries for their crystal modifying, anti-rust, and anti-corrosion properties. (A2881)
Use ClassificationCosmetics -> Cleansing; Surfactant; Hair conditioning; Antistatic
General Manufacturing InformationGlycine, N-methyl-N-(1-oxotetradecyl)-: ACTIVE
Anbieter11 Anbieter
陕西格列弗生物科技研究有限责任公司18409274651; 13892423764 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
上海钰康生物科技有限公司+86-18930848214 +86-021-56762820 · [email protected]
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