1-(6-((17-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione
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Grundinformationen
- CAS
112648-68-7- Standard-SMILES
COc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](NCCCCCCN3C(=O)C=CC3=O)CC[C@@H]12- InChIKey
LUFAORPFSVMJIW-ZRJUGLEFSA-N- Summenformel
- C29H40N2O3
- Durchschnittliche Molmasse
- 464,65 g/mol
- Monoisotopische Masse
- 464,30389314
Namen und Bezeichner
- Bevorzugter Name
- 1-(6-((17-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione
- IUPAC
- 1-(6-{[3-Methoxyestra-1,3,5(10)-trien-17beta-yl]amino}hexyl)-1H-pyrrole-2,5-dione
- Englischer Name
- U-73122
- Summenformel
- C29H40N2O3
- Molmasse
- 464.64
Namen und Synonyme
U-73312U-73122CS-1793CS-2400U-73122 98%U 73122U-73122CAS:112648-68-7U-73122 hydrateU-73122 USP/EP/BPU-73122, 10 mM in DMSO
Datenbank-Bezeichner
- CAS
112648-68-7- PubChem CID
- 104794
- DTXSID
DTXSID3036739- ChEMBL
CHEMBL1256678- ChEBI
CHEBI:90690- EC Number
- 634-540-9
- Nikkaji
- J336.364C
Eigenschaften
Physikochemische Eigenschaften
- Siedepunkt
- 617.1 · 617.1±55.0 °C(Predicted)
- Dichte
- 1.16 · 1.16±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- Löslichkeit
- 0.7 mg/mL · ethanol: 0.7 mg/mL
- Aggregatzustand
- solid
- pka
- 10.69 · 10.69±0.40(Predicted)
- Farbe
- off-white
- Wasserlöslichkeit
- 0.5 mg/ml · Soluble in DMSO, ethanol, or DMF at approx. 0.5mg/ml. May require heating or overnight mixing. Insoluble in water
- Stabilität
- 1 year · Stable for 1 year from date of purchase as supplied. Use caution when storing DMSO solutions. Typically solutions in DMSO can be stored at -20°C for approximately 2 months. However, any solutions that turn pink should be discarded.
- InChIKey
- LUFAORPFSVMJIW-PFQOISFUNA-N
- SMILES
- [C@@]12([H])CCC3C=C(OC)C=CC=3[C@@]1([H])CC[C@]1(C)[C@H](CC[C@@]21[H])NCCCCCCN1C(=O)C=CC1=O |&1:0,12,16,18,21,r|
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26-36
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Anwendungen
BeschreibungU-73122 is an inhibitor of PLC-dependent processes, however, the mechanism of action remains unclear. The IC50 values for inhibition of platelet aggregation induced by collagen or thrombin are 0.6 and 5 μM, respectively. It also exhibits inhibitory activity against HIV-1 integrase with an IC50 value of 7 μM.
VerwendenIt is used as a phospholipase C, phospholipase A2, and 5-LO inhibitor. It is also determined that in SK-N-SH neuroblastoma cells, U-73122 inhibits agonist-induced down-regulation of muscarinic receptors. In addition, it is a useful tool to investigate receptor-mediated PI turnover in signal transduction. U-73122 is a potent inhibitor of human neutrophil adhesion to biological surfaces (IC50 = 50 nM) as well as adhesion-dependent granule exocytosis and oxidative burst. U-73343 (sc-201422) is useful as a negative control for investigations of U-73122 phospholipase C antagonism and its cellular consequences.
Anbieter78 Anbieter
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
咸宁深蓝生物医药研发有限公司18171815831 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
江苏星科元信息科技有限公司400-605-7200 15335295587 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
武汉易泰科技有限公司上海分公司
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