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Guanidiniumnitrat
GUN · GUANIDINIUM NITRATE · XSG · Guanidinnitrat · Uraminenitrate · GUANIDINENITRATE · Iminoureamitrate · GUANIDINE NITRATE
Identifikatoren & physikalische Daten
| CAS No. | 506-93-4 |
|---|---|
| Summenformel | CH5N3.HNO3 |
| Durchschnittliche Molmasse | 122,08 g/mol |
| Monoisotopische Masse | 122,04399005 g/mol |
| SMILES | N=C(N)N.O=[N+]([O-])O |
| InChIKey | CNUNWZZSUJPAHX-UHFFFAOYSA-N |
| PubChem CID | 10481 |
| EC No. | 208-060-1 |
| DTXSID | DTXSID3027164 |
| Lokaler Name | Guanidiniumnitrat |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 142 |
|---|---|
| H-Brücken-Donoren | 4 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 8 |
| Formalladung | 0 |
| Komplexität | 51 |
| Stoffklassen | Nitrogen Compounds -> Nitrates and NitritesReactive agents - 3rd degree |
| pH | Aq solution is neutral4.9 (165g/l, H2O, 25℃) |
| LogP (Verteilungskoeffizient) | -8.35 |
| Dichte | 1.436 g/cm³1.44 |
| Color/Form | Crystalline powder |
| Löslichkeit | Sol in 10 parts watersol in alcoholSLIGHTLY SOL IN ACETONESolubility in water, g/100ml at 20 °C: 16water: soluble50mg/mL, clear to very slightly hazy, colorless130 g/L (20 ºC) |
| Siedepunkt | Decomposes at boiling point227.45°C (rough estimate) |
| Decomposition | When heated to decomposition it emits very toxic fumes of Nitric acid and /Nitrogen oxide/. |
| Schmelzpunkt | 214 °C217 °C213-215 °C(lit.) |
| Physical Description | Guanidine nitrate appears as a white crystalline solid. Soluble in water. Takes some effort to ignite but once ignited it burns with increasing vigor as the fire progresses. If contaminated with combustible materials it accelerates their burning. Prolonged exposure to fire or heat may result in an explosion. Produces toxic oxides of nitrogen during combustion.Dry PowderLarge CrystalsLiquidWhite solid[Hawley] White crystalline powder[MSDSonline]WHITE SOLID IN VARIOUS FORMS. |
| Other Experimental Properties | Strong oxidant |
| Dampfdruck | 0Pa at 25℃ |
| Brechungsindex | 1.4164 (estimate) |
| Lagerbedingungen | Store below +30°C. |
| pKa (Säurekonstante) | 10.2[at 20 ℃] |
| Aggregatzustand | crystalline powder |
| Farbe | White |
| Geruch | Odorless |
| Merck | 14,4562 |
| BRN | 3596600 |
| Stabilität | May explode if heated. May be shock sensitive. |
| InChI | 1S/CH5N3.HNO3/c2*2-1(3)4/h(H5,2,3,4)(H,2,3,4) |
| InChIKey | CNUNWZZSUJPAHX-UHFFFAOYSA-N |
| SMILES | NC(N)=N.O[N+]([O-])=O |
| LogP (Verteilungskoeffizient) | -1.7 at 20℃ |
| CAS Datenbank | 506-93-4(CAS DataBase Reference) |
| EPA chemische Informationen | Guanidine nitrate (506-93-4) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH272 (29.8%): May intensify fireoxidizer [Danger Oxidizing liquidsOxidizing solids]P210, P220, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P370+P378, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 178 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H272: May intensify fire |
|---|---|
| Regulatorische Informationen | Guanidine, nitrate (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Guanidine, nitrate (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 29-03-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/16017Guanidinium nitrate: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| DOT-Kennzeichnung | Oxidizer |
| Brandgefahren | Excerpt from ERG Guide 143 [Oxidizers (Unstable)]:· May explode from friction, heat or contamination.Gives off irritating or toxic fumes (or gases) in a fire. Risk of fire and explosion. Explosive. |
| Brandpotenzial | Explosive. Gives off irritating or toxic fumes (or gases) in a fire.MAY IGNITE ORGANIC MATERIALS ON CONTACT... |
| Gesundheitsgefahren | Excerpt from ERG Guide 143 [Oxidizers (Unstable)]:· TOXICinhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. |
| Gefahrenübersicht | May decompose explosively from shock, friction, or concussionHeating may cause explosionA severe skin and eye irritant[ICSC] A strong oxidizer[CAMEO] A mild eye irritant and severe skin irritant in rabbits[RTECS] Can cause fire on contact with combustible materialAn irritant[MSDSonline] See Guanidine. |
| DOT-Nummer und Handbuch | 1467 143 |
| Reaktive Gruppe | Amines, Phosphines, and Pyridines |
| UN-Einstufung | UN Hazard Class: 5.1UN Pack Group: III |
| Special Reports | European Chemicals BureauIUCLID Dataset, Guanidinium nitrate (CAS # 506-93-4) (2000 CD-ROM edition). Available from the Database Query page at: http://ecb.jrc.it/esis/esis.php as of February 5, 2008. |
| Reactivity Alerts | Explosive |
| Reactivity Profile | GUANIDINE NITRATE can explode. Demolished an autoclave built to withstand 50 atmospheres when it exploded as it was being synthesized from ammonium thiocyanate and lead nitrate [C. Angew Chem. 49:23(1936)]. Acts an an oxidizing agent with organic matter. |
| Brandbekämpfung | Excerpt from ERG Guide 143 [Oxidizers (Unstable)]:Use water in large amounts. In case of fire: keep drums, etc., cool by spraying with water. |
| Erste-Hilfe-Maßnahmen | Fresh air, rest.First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention . |
| Freisetungsmaßnahmen | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· Keep combustibles (wood, paper, oil, etc.) away from spilled material. |
| Erste Hilfe | Excerpt from ERG Guide 143 [Oxidizers (Unstable)]:General First Aid: |
| Sichere Lagerung | Fireproof. Store in an area without drain or sewer access. Separated from combustible substances and reducing agents. |
| Expositionsschutz und Persönliche Schutzausrüstung | · Wear positive pressure self-contained breathing apparatus (SCBA). |
| Brandbekämpfungsverfahren | If material on fire or involved in fire: Flood with water. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.Evacuation: If fire becomes uncontrollable - consider evacuation of one-half (1/2) mile radius. |
| Lagerbedingungen | Fireproof. Store in an area without drain or sewer access. Separated from combustible and reducing substances. |
| Reinigungsverfahren | Evacuate danger area and consult an expert in case of large spill. Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Do NOT absorb in saw-dust or other combustible absorbents. Sweep spilled substance into covered containersif appropriate, moisten first to prevent dusting. |
| Freisetung ohne Brand | Excerpt from ERG Guide 143 [Oxidizers (Unstable)]: |
| Entsorgungsverfahren | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
| Verschüttetes entsorgen | Evacuate danger area! Consult an expert! Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Do NOT absorb in saw-dust or other combustible absorbents. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. |
| Treatment | Methemoglobinemia can be treated with supplemental oxygen and methylene blue 1% solution administered intravenously slowly over five minutes followed by IV flush with normal saline. Methylene blue restores the iron in hemoglobin to its normal (reduced) oxygen-carrying state. (L1613) |
| Wechselwirkungen | Growth retardation of rats exposed to the smoke of high-sugar cigarettes was decreased by the addition of guanidine nitrate to the cigarettes. |
| Gesundheitliche Auswirkungen | Nitrate and nitrite poisoning causes methemoglobinemia. Nitrites may cause pregnancy complications and developmental effects. They may also be carcinogenic. (L1137) |
| Ökotoxizitätswerte | LC50 Leuciscus idus (carp) 2420 mg/L/48 hr /Conditions of bioassay not specified in source examined/LC50 Pimephales promelas (fathead minnow) 690 mg/L/96 hrConditions: flow-through, 20 to 22 °CLC50 Ictalurus punctatus (channel catfish) 1850 mg/L/96 hrEC50 Daphnia magna (water flea) 70.2 mg/L/48 hrConditions: 20 °CEffect: immobilization testFor more Ecotoxicity Values (Complete) data for GUANIDINE, MONONITRATE (9 total), please visit the HSDB record page. |
| Expositionspfade | The substance can be absorbed into the body by ingestion.Oral (L1137)inhalation (L1137) |
| Toxizitätsübersicht | Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613) |
| Signs and Symptoms | Sore throat. Cough.Redness. Pain.Nitrate and nitrite poisoning causes methemoglobinemia. Symptoms include cyanosis, cardiac dysrhythmias and circulatory failure, and progressive central nervous system (CNS) effects. CNS effects can range from mild dizziness and lethargy to coma and convulsions. (L1137) |
| ICSC Environmental Data | The substance is harmful to aquatic organisms. |
| Human Toxicity Excerpts | /ALTERNATIVE and IN VITRO TESTS/ Guanidinium nitrate in vitro caused a significant concentration-related hemolysis of erythrocyte suspensions in humans. |
| Carcinogen Classification | Ingested nitrate or nitrite under conditions that result in endogenous nitrosation is probably carcinogenic to humans (Group 2A). (L135) |
| Non-Human Toxicity Excerpts | /LABORATORY ANIMALS: Acute Exposure/ In rabbits administered 2,000 mg/kg bw by 24 hr semi-occlusive /dermal/ application, no substance-related deaths or clinical signs of toxicity were observed./LABORATORY ANIMALS: Acute Exposure/ The test material was described as slightly irritating to rabbit skin using the Draize method as prescribed in EPA Guideline (1982). Quantity applied: 2,000 mg/kg bw semiocclusively for 24 hrafter 0.5 hr erythema in 9/10 animals and edema in 2/10 animals. After 72 hr erythema in 2/10 animals without observation of edema./LABORATORY ANIMALS: Acute Exposure/ Described as highly irritating in the rabbit using the Draize method as described in EPA Guideline (1982). Application quantity: 500 mgsemiocclusive patch for 24 hrafter 14 days, 7/8 animals showed erythemafor edema after 24 hr 4/8 animals with an index of 1, 3/8 animals with an index of 2 and 1/8 with an index of 4after 14 days no further edema was observed./LABORATORY ANIMALS: Acute Exposure/ Test material described as slightly irritating when applied to the skin /rabbit/ using OECD Guideline 404: Acute Dermal Irritation/Corrosion. Application amount: 500 mgsemiocclusive for 4 hoursslight erythema and edema in 1/3 animals after 1 hr.For more Non-Human Toxicity Excerpts (Complete) data for GUANIDINE, MONONITRATE (8 total), please visit the HSDB record page. |
| Antidote and Emergency Treatment | /SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B//SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B//SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/ |
| Wassergefährdungsklasse (WGK) | 1 |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN 1467 |
| Zollcode | 29252000 |
| RTECS-Nr. | MF4350000 |
| R-Sätze (R) | 8-22-36/37/38-5 |
| Gefahrensymbole | O,Xn,Xi |
| Sicherheitshinweise (S) | 17-26-36-15 |
| Gefahrenklasse | 5.1Acute Tox. 4 OralAquatic Chronic 3Eye Irrit. 2Ox. Sol. 3 |
| Verpackungsgruppe | III |
| Lagerklasse | 5.1B - Oxidizing hazardous materials |
| Gefahrstoffdaten | 506-93-4(Hazardous Substances Data) |
Anwendungen & Verwendung
Verwenden
Guanidine nitrate is the salt formed from guanidine and nitric acid and has been used as a high energy fuel used in gas generators and propellant applications.