Methoxyfenozide

Remain upwind. Avoid breathing smoke. Use water spray to cool containers exposed to fire. Contain run-off. /Intrepid 2F Insecticide/

Wear positive-pressure, self-contained breathing apparatus and full protective clothing. Do not allow water from fire-fighting to enter water supplies. /Intrepid 2F Insecticide/

Use the following extinguishing media when fighting fires involving this material: carbon dioxide, dry chemical, water spray or foam. /Intrepid 2F Insecticide/

Do not store this material near food, feed or drinking water. The minimum recommended storage temperature for this material is 32 °F (0 °C). The maximum recommended storage temperature for this material is 104 °F (40 °C). Store in a well-ventilated area. Keep container tightly closed when not in use. /Intrepid 2F Insecticide/

Store in a cool dry well-ventilated area, but not below 32 °F. /Intrepid 2F Insecticide/

Contain and absorb small spills with inert materials with sand or earth. Transfer liquids and solid diking material to separate suitable containers for recovery or disposal. Avoid breathing vapor. Keep spills and cleaning run-off out of municipal sewers and open bodies of water. ... . If exposed to material during clean-up operations, remove all contaminated clothing promptly. Wash all exposed skin areas with soap and water immediately after exposure. Thoroughly lauder clothing before reuse. Do not take clothing home to be laundered. /Intrepid 2F Insecticide/

Do not contaminate water when cleaning equipment or disposing of equipment washwaters. /Intrepid 2F Insecticide/

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Wastes resulting from the use of this product must be disposed of on site or at an approved waste disposal facility. /Intrepid 2F Insecticide/

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR Part 170. /Intrepid 2F Insecticide/

For terrestrial uses, do not apply directly to water or to areas where surface water is present or to intertidal areas below the mean high water mark. /Intrepid 2F Insecticide/

Users should: Wash hands before eating, drinking, chewing gum, using tobacco or using the toilet. Remove contaminated clothing immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing. /Intrepid 2F Insecticide/

Follow manufacturer's instructions for cleaning/maintaining personal protective equipment (PPE). If not such instructions for washables, use detergent and hot water. Keep and wash PPE separately from other laundry. /Intrepid 2F Insecticide/

For more Preventive Measures (Complete) data for Methoxyfenozide (7 total), please visit the HSDB record page.

Tolerances are established for residues of the insecticide methoxyfenozide per se; benzoic acid, 3-methoxy-2-methyl-, 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl) hydrazide in or on the following food commodities: [Table#7777]

For combined residues of the insecticide methoxyfenozide; benzoic acid, 3-methoxy-2-methyl-, 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl) hydrazide and its glucuronide metabolite RH-141,518; beta-D-Glucopyranuronic acid, 3-[2-(1,1-dimethylethyl)-2-(3,5-dimethylbenzoyl)-hydrazino]carbonyl-2-methylphenyl-] in the following commodities: [Table#7778]

Time-limited tolerances specified in the following table are established for residues of the insecticide methoxyfenozide per se (benzoic acid, 3-methoxy-2-methyl-,2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl) hydrazide), in or on the specified agricultural commodities, resulting from use of the pesticide pursuant to FFIFRA section 18 emergency exemptions. The tolerances expire and will be revoked on the date specified in the table. [Table#7779]

Tolerances with regional registrations. Tolerances are established for residues of the insecticide methoxyfenozide, including its metabolites and degradates. Compliance with the tolerance levels specified in this paragraph is to be determined by measuring only methoxyfenozide, benzoic acid, 3-methoxy-2-methyl-, 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl) hydrazide. [Table#7780]

For more Allowable Tolerances (Complete) data for Methoxyfenozide (6 total), please visit the HSDB record page.

Applicators and other handlers must wear: Long-sleeved shirt and long pants. Chemical-resistant gloves made of any waterproof material. Shoes plus socks. /Intrepid 2F Insecticide/

... Restricted-entry interval (REI) of 4 hours. Personal protective equipment (PPE) required for early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated, such as plants, soil, or water is: Coveralls, Chemical resistant gloves made of any waterproof material. Shoes plus socks. /Intrepid 2F Insecticide/

LC50; Species: Anas platyrhynchos (Mallard Duck, age 10 days) diet >5870 ppm for 8 days

LC50; Species: Colinus virginianus (Northern Bobwhite Quail, age 10 days) diet >5870 ppm for 8 days

LD50; Species: Colinus virginianus (Northern Bobwhite Quail, age 10 days) oral via capsule >2250 mg/kg

EC50; Species: Pseudokirchneriella subcapitata (Green Algae); Conditions: freshwater, static; Concentration: >3400 ug/L for 5 days; Effect: decreased population abundance /98% purity/

For more Ecotoxicity Values (Complete) data for Methoxyfenozide (10 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1,100(SRC), determined from a log Kow of 3.7(2) and a regression-derived equation(3), indicates that methoxyfenozide is expected to have low mobility in soil(SRC). Volatilization of methoxyfenozide from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.8X10-12 atm-cu m/mole(SRC), using a fragment constant estimation method(4). Methoxyfenozide is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3.5X10-11 mm Hg at 25 °C(SRC), determined from a fragment constant method(5). Biodegradation data in soil were not available(SRC, 2011).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1,100(SRC), determined from a log Kow of 3.70(2) and a regression-derived equation(3), indicates that methoxyfenozide is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 3.8X10-12 atm-cu m/mole(SRC), developed using a fragment constant estimation method(5). According to a classification scheme(6), an estimated BCF of 130(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is high, provided the compound is not metabolized by the organism(SRC). Using natural lake water, an aqueous photolysis half-life range of 7 to 10 days has been reported(7). Biodegradation data in water were not available(SRC, 2011).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), methoxyfenozide, which has an estimated vapor pressure of 3.5X10-11 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase. Particulate-phase methoxyfenozide may be removed from the air by wet or dry deposition(SRC). Methoxyfenozide contains chromophores that absorb at wavelengths >290 nm(4), and therefore may be susceptible to direct photolysis by sunlight(SRC).

The Koc of methoxyfenozide is estimated as 1100(SRC), using a log Kow of 3.70(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that methoxyfenozide is expected to have low mobility in soil.

An estimated BCF of 130 was calculated in fish for methoxyfenozide(SRC), using a log Kow of 3.70(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC), provided the compound is not metabolized by the organism(SRC).

The Henry's Law constant for methoxyfenozide is estimated as 3.8X10-12 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that methoxyfenozide is expected to be essentially nonvolatile from water and moist soil surfaces(2). Methoxyfenozide is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3.5X10-11 mm Hg(SRC), determined from a fragment constant method(3).

/LABORATORY ANIMALS: Acute Exposure/ Methoxyfenozide was not irritating to rabbit skin and produced only minimal, transient irritation to rabbit eyes. Negative results were obtained in a Magnusson and Kligman maximization test for skin sensitization in guinea-pigs.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ In an initial study, groups of five male and five female Crl: CD BR rats were given diets containing methoxyfenozide (purity, 90%) at concentrations of up to 20,000 mg/kg for 2 weeks. All rats were observed routinely for signs of ill health or reaction to treatment, body weight and feed consumption. After 2 weeks of treatment, blood samples were collected for measurement of hematology (including reticulocytes, but not methemoglobin formation) and clinical chemistry parameters. Histological examination was limited to seven major organs at the highest dose and controls, except for the liver, thyroid and pituitary where there was evidence of substance-related effects at the highest dose. There were no deaths and no effects on clinical signs, body weight or feed consumption were evident. No treatment-related adverse hematological effects were observed in either sex at any dose. No clear treatment-related clinical chemistry changes were seen in males at doses of up to 5,000 mg/kg or in females at doses of up to 20,000 mg/kg. A treatment-related decrease (by 47%, statistically significant) in triglyceride concentrations was observed in males at 20,000 mg/kg. Increases in absolute and relative weights of liver (14-23%) and adrenals (up to 30%) were noted at >5000 mg/kg. Minimal to slight hepatocyte hypertrophy was observed in all rats at 20,000 mg/kg and in three females at 5,000 mg/kg. There was evidence of single cell necrosis in the livers of animals receiving 20,000 mg/kg. A dose-related minimal to slight hypertrophy and/or hyperplasia of the follicular cells of the thyroid occurred in male and female rats at >/= 1,000 mg/kg. Minimal hypertrophy of the zona fasciculata of the adrenal cortex was seen in three females at 20,000 mg/kg. Isolated findings of adrenal hypertrophy in females at 1,000 and 5,000 mg/kg were of questionable significance. The NOAEL was 250 mg/kg (equal to 24 mg/kg per day) on the basis of follicular cell hypertrophy and/or hyperplasia of the thyroid in both sexes at 1000 mg/kg (equal to 98 mg/kg bw per day).

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ In an initial study, groups of five female Crl:CD-1(ICR)BR mice were given diets containing methoxyfenozide (purity, 99.2%) at a concentration of 0, 50, 250, 1000, 2500 or 7000 mg/kg for 2 weeks. Limited investigations of clinical chemistry and hematology were performed in addition to routine investigations of mortality, clinical signs, body weight and food consumption. Microscopic examination was performed on the thyroid, liver, spleen, adrenals, kidney and pituitary from animals in the control group and the group receiving the highest dose. In addition, the liver from each mouse in all other treatment groups was also examined microscopically. No clinical signs of ill health or reaction to treatment after 2 weeks of dietary exposure to methoxyfenozide were recorded. No treatment-related effects on hematology, clinical chemistry, body weight or food consumption were observed. The only findings of note were a statistically significant increase in relative liver weights at 7000 mg/kg and periportal hepatocyte hyperplasia at >/= 2500 mg/kg. The no-observed-adverse-effect level (NOAEL) was 1000 mg/kg (equal to 217 mg/kg per day) on the basis of histopathological changes in the liver at 2500 mg/kg.

Methoxyfenozide is stable to hydrolysis at pH 5, 7 and 9(1) and has been reported as relatively not important in the environment when compared to photolysis(2). Methoxyfenozide contains chromophores that absorb at wavelengths >290 nm(3), and therefore may be susceptible to direct photolysis by sunlight(SRC). A photolytic half-life in pond water of 77 days has been reported(1). Photodecomposition in aqueous solutions (sterilized lake water from Guishui Lake, south of Beijing China) follows first-order kinetics under UV and natural sunlight. This slightly eutrophic lake is influenced by agricultural runoff(2). Half-lives of 10.85 minutes and 6.63-10.16 days, under UV (detection performed at 230 nm) and natural sunlight conditions (sunlight intensity at 300 to 400 nm), respectively, have been reported(2). Under UV degradation, two products were identified: N-t-butyl-N-(3,5-dimethylbenzoyl) and 3,7-dimethyl-benzoatedihydrofuran(2). A soil photolysis half-life has been reported as 173 days(1).

Methoxyfenozide's production may result in its release to the environment through various waste streams; its use as an insecticide will result in its direct release to the environment. If released to air, an estimated vapor pressure of 3.5X10-11 mm Hg at 25 °C indicates methoxyfenozide will exist solely in the particulate phase in the atmosphere. Particulate-phase methoxyfenozide will be removed from the atmosphere by wet or dry deposition. Methoxyfenozide contains chromophores that absorb at wavelengths >290 nm, and therefore may be susceptible to direct photolysis by sunlight. If released to soil, methoxyfenozide is expected to have low mobility based upon an estimated Koc of 1,100. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 3.8X10-12 atm-cu m/mole. Methoxyfenozide may not volatilize from dry soil surfaces based upon its vapor pressure. Biodegradation data were not available. If released into water, methoxyfenozide is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. An estimated BCF of 130 suggests the potential for bioconcentration in aquatic organisms is high, provided the compound is not metabolized by the organism. Methoxyfenozide is stable to hydrolysis at environmental pH. Using natural lake water, an aqueous photolysis half-life range of 7 to 10 days has been reported. Occupational exposure to methoxyfenozide may occur through inhalation and dermal contact with this compound at workplaces where methoxyfenozide is produced or used. (SRC)

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

Tolerances are established for residues of the insecticide methoxyfenozide per se; benzoic acid, 3-methoxy-2-methyl-, 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl) hydrazide in or on the following food commodities: [Table#7783]

Reregistration Eligibility Decision (RED) Scheduled for 2013

For combined residues of the insecticide methoxyfenozide; benzoic acid, 3-methoxy-2-methyl-, 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl) hydrazide and its glucuronide metabolite RH-141,518; beta-D-Glucopyranuronic acid, 3-[2-(1,1-dimethylethyl)-2-(3,5-dimethylbenzoyl)-hydrazino]carbonyl-2-methylphenyl-] in the following commodities: [Table#7784]

Time-limited tolerances specified in the following table are established for residues of the insecticide methoxyfenozide per se (benzoic acid, 3-methoxy-2-methyl-,2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl) hydrazide), in or on the specified agricultural commodities, resulting from use of the pesticide pursuant to FFIFRA section 18 emergency exemptions. The tolerances expire and will be revoked on the date specified in the table. [Table#7785]

For more FIFRA Requirements (Complete) data for Methoxyfenozide (7 total), please visit the HSDB record page.

For methoxyfenozide (USEPA/OPP Pesticide Code: 121027) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

Insecticide

This is a man-made compound that is used as a pesticide.

Suspension concentrate, wettable powder.

Methoxyfenozide Technical (Dow Agrosciences, LLC) Methoxyfenozide 98.2%

Intrepid 80WSP Agricultural Insecticide (Dow Agrosciences, LLC) Methoxyfenozide 80%

Intrepid 2F Agricultural Insecticide (Dow Agrosciences, LLC) Methoxyfenozide 22.6%

Intrepid Mup (Dow Agrosciences, LLC) Methoxyfenozide 80%

Insecticides

Environmental transformation -> Pesticides (parent, predecessor)