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Trimethylphosphat
TMP · METHYL PHOSPHATE · (CH3O)3PO · Trimethyl phosphate(Trimethoxyphosphine oxide,Trimethyl orthophosphate) · zCCCCFYZX · NCI-C03781 · TriMethylphosp · Trimethylfosfat
Identifikatoren & physikalische Daten
| CAS No. | 512-56-1 |
|---|---|
| Summenformel | C3H9O4P |
| Durchschnittliche Molmasse | 140,07 g/mol |
| Monoisotopische Masse | 140,0238454 g/mol |
| SMILES | COP(=O)(OC)OC |
| InChIKey | WVLBCYQITXONBZ-UHFFFAOYSA-N |
| PubChem CID | 10541 |
| ChEMBL | CHEMBL1236486 |
| ChEBI | CHEBI:46324 |
| EC No. | 208-144-8 |
| DTXSID | DTXSID1021403 |
| Lokaler Name | Trimethylphosphat |
Chemische & physikalische Eigenschaften
| XLogP | -0,5 |
|---|---|
| Polarare Oberfläche (TPSA) | 44,8 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 3 |
| Schwere Atome | 8 |
| Formalladung | 0 |
| Komplexität | 82,4 |
| Stoffklassen | Other Classes -> Organophosphates, Other |
| SpringerMaterials Properties | Schoenflies notation |
| LogP (Verteilungskoeffizient) | log Kow = -0.52 and -0.78-0.52,-0.78 |
| Geruch | Pleasant smelling |
| Dichte | 1.2144 at 68 °F (NTP, 1992) - Denser than waterwill sink1.2144 g/cu cm at 20 °CRelative density (water = 1): 1.21.97 @ 19.5°C1.197 g/mL at 25 °C (lit.) |
| Color/Form | LiquidColorless liquid |
| Löslichkeit | greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)In water, 5.0X10+5 mg/L at 25 °CSlightyl soluble in ethanolsoluble in ethyl etherSoluble in alcohol, ether and organic solventsSoluble in gasolineSolubility in water, g/100ml at 25 °C: 50 (good)1000g/l500 G/L (25 ºC) |
| Flammpunkt | greater than 300 °F (NTP, 1992)107 °C150 °C (302 °F) (Closed cup) |
| Siedepunkt | 387 °F at 760 mmHg (NTP, 1992)197.2 °C197.2 °C @760 [mm Hg]197 °C (lit.) |
| Decomposition | When heated to decomposition it emits toxic fume of phosphorus oxides. |
| Schmelzpunkt | -51 °F (NTP, 1992)-46 °C-46 °C (lit.) |
| Dampfdruck | 1 mmHg at 78.8 °F5 mmHg at 128.7 °F10 mmHg at 154.0 °F (NTP, 1992)0.85 mm Hg at 25 °CVapor pressure, kPa at 20 °C: 0.111.133 hPa (25 °C) |
| Brechungsindex | n20/D 1.395(lit.) |
| Lagerbedingungen | Store below +30°C. |
| Aggregatzustand | Liquid |
| Farbe | Clear |
| Wichte | 1.197 |
| BRN | 1071731 |
| Henry-Konstante | 1.4×103 mol/(m3Pa) at 25℃, Wolfenden and Williams (1983) |
| Dielektrizitätskonstante | 21.260000000000002 |
| InChI | 1S/C3H9O4P/c1-5-8(4,6-2)7-3/h1-3H3 |
| InChIKey | WVLBCYQITXONBZ-UHFFFAOYSA-N |
| SMILES | COP(=O)(OC)OC |
| LogP (Verteilungskoeffizient) | -0.46 at 25℃ |
| CAS Datenbank | 512-56-1(CAS DataBase Reference) |
| NIST chemische Informationen | Phosphoric acid, trimethyl ester(512-56-1) |
| EPA chemische Informationen | Trimethyl phosphate (512-56-1) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 35.1% (121 of 345) of reports.DangerH302 (58.6%): Harmful if swallowed [Warning Acute toxicity, oral]P203, P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P351+P338, P318, P321, P330, P332+P317, P337+P317, P362+P364, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 345 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | Chemical: Phosphoric acid, trimethyl esterHazard Traits - CarcinogenicityPhosphoric acid, trimethyl ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Phosphoric acid, trimethyl ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 16-11-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/22505Trimethyl phosphate: Does not have an individual approval but may be used under an appropriate group standard |
| Weitere Sicherheitsinformationen | IMAP assessments - Phosphoric acid, trimethyl ester: Human health tier II assessment |
| Brandgefahren | This chemical is nonflammable. (NTP, 1992)Combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| Gesundheitsgefahren | SYMPTOMS: Symptoms of exposure to this compound include strong irritation of the skin and eyes. Irritation of the mucous membranes and respiratory tract also occurs. |
| Gefahrenübersicht | Danger of cutaneous absorptionCarcinogenicity in man cannot be assessed conclusively because of insufficient data (Group 3B)Germ cell mutagens that have shown to increase the mutant frequency in the progeny of exposed mammals. [MAK] A skin, eye, and respiratory tract irritantChronic or repeated exposure may cause flaccid paralysis and genetic damage[ICSC] An irritantTargets CNS[MSDSonline] |
Anwendungen & Verwendung
Verwenden
Trimethyl phosphate is used as an intermediate in organic synthesis. Its industrial applications are much fewer than those of other organic phosphates.Trimethyl phosphate undergoes hydrolysis in contact with water, so it should be stored in a moisture-proof manner. Due to its hydrolysis and release of PO43-, thus becoming a homogeneous precipitant for the formation of insoluble phosphate precipitation, often used as a precipitation reagent for zirconium and hafnium and as a diffusion source for the determination of semiconductors. In addition, trimethyl phosphate is also a phospholipid extractant for the extraction and separation of certain metal ions.