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Ecothiopatiodid

Echothiophate Iodide

HCID 10547
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GrundinformationenÜberblickNamen und BezeichnerEigenschaftenSicherheit und RegulatorischesChemie und IndustrieZugehörige ReaktionenNotizen zur Verbindung
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Grundinformationen

CAS
513-10-0
Standard-SMILES
CCOP(=O)(OCC)SCC[N+](C)(C)C.[I-]
InChIKey
OVXQHPWHMXOFRD-UHFFFAOYSA-M
Summenformel
C9H23INO3PS
Durchschnittliche Molmasse
383,23 g/mol
Monoisotopische Masse
383,0181

Überblick

Ecothiopate iodide is the iodide salt of ecothiopate. An irreversible acetylcholinesterase inhibitor, it is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inadequate. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor, an antiglaucoma drug and a miotic. It is an iodide salt and a quaternary ammonium salt. It contains an ecothiopate.

Namen und Bezeichner

Bevorzugter Name
Echothiophate Iodide
IUPAC
2-diethoxyphosphorylsulfanylethyl(trimethyl)azanium iodide
Lokaler Name
Ecothiopatiodid
Englischer Name
Ecothiopate iodide
Summenformel
C9H23INO3PS
Molmasse
383.227051

Namen und Synonyme

Echothiophate iodideECOTHIOPATE IODIDE513-10-0EchodideEcothiophate iodideEcothiopati iodidumPhospholine iodideIodure d'ecothiopateIoduro de ecotiopato217-miDiethoxyphosphoryl-thiocholine iodideEchothiophate iodide (USP)
Weitere Namen anzeigen
ECHOTHIOPHATEEcothiopate217MIEcostigmineECOTHIOPHATEPHOSPHOLINEIODIDEEchothiopate iodide
2-Diethoxy-phosphinylthioethyl-trimethylammonium iodideBA9QH3P00TEthanaminium, 2-((diethoxyphosphinyl)thio)-N,N,N-trimethyl-, iodideN-(2-(Diethoxyphosphinylthio)ethyl)trimethylammonium iodideO,O-Diethyl S-2-trimethylammonium ethylphosphonothiolate iodideDTXSID1022976S-(2-(N,N,N-Trimethylammonio)ethyl) O,O-diethylphosphorothiolate iodide(2-Mercaptoethyl)trimethylammonium iodide S-ester with O,O-diethyl phosphorothioate

Datenbank-Bezeichner

CAS
513-10-0
PubChem CID
10547

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
60,8 Ų
H-Brücken-Donoren
0
H-Brücken-Akzeptoren
5
Frei drehbare Bindungen
8
Schwere Atome
16
Formalladung
0
Komplexität
208

Experimentelle und physikochemische Eigenschaften

Human Drugs · 3 Einträge

Breast Feeding; Lactation; Cholinesterase Inhibitors; Miotics; Parasympathomimetics

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Physikochemische Eigenschaften

Schmelzpunkt
138 ° · 138° (Tammelin); mp 124-124.5° (Fitch)
storage temp.
-20 °C · Store at -20°C
Löslichkeit
DMSO: Slightly Soluble; Methanol: Slightly Soluble; Water: Slightly Soluble
Aggregatzustand
A solid
Stabilität
Hygroscopic
EPA chemische Informationen
2 · Ethanaminium, 2-[(diethoxyphosphinyl)thio]-N,N,N-trimethyl-, iodide (513-10-0)

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

Toxikologische Informationen

Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

Sicherheitsdaten

ridadr
3249
hazard_class
6.1(a)
packing_group
II

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological Classification · 3 Einträge

Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.

Agents causing contraction of the pupil of the eye. Some sources use the term miotics only for the parasympathomimetics but any drug used to induce miosis is included here.

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.

Anwendungen · 2 Einträge

VerwendenCholinergic (ophthalmic).

VerwendenEchothiophate is a phosphorylthiocholine with pharmacological action analogous to that of isofluorophate; however, spontaneous reduction of phosphorylated enzyme occurs faster after using isofluorophate. It is used in various forms of glaucoma.

Vor- und nachgelagerte Produkte

Vorgelagerte Rohstoffe

MethyljodidNatriumDiethylchlorphosphat

Anbieter11 Anbieter

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Notizen zur Verbindung

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Auf dieser SeiteGrundinformationenÜberblickNamen und BezeichnerEigenschaftenSicherheit und RegulatorischesChemie und IndustrieZugehörige ReaktionenNotizen zur Verbindung
DTXSID
DTXSID1022976
ChEMBL
CHEMBL1200367
ChEBI
CHEBI:59849
UNII
BA9QH3P00T
EC Number
208-152-1
安耐吉化学&3A(安徽泽升科技有限公司)021-58432009 400-005-6266 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
Chongqing jooe co., ltd+86-15223382610 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
艾吉析科技(上海)有限公司17717235263 17717235263 · [email protected]
TargetMol中国(陶术生物)4008200310 15002144251 · [email protected]
ChemeGen 中国18818260767 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]
AFINE CHEMICALS LIMITED+86-571-85134551 +86-18958018566 · [email protected]

Ergänzende Hinweise

DefinitionChEBI: The iodide salt of ecothiopate. An irreversible acetylcholinesterase inhibitor, it is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inadequate.