5-Amino-1,2,3,4-tetrahydrophtha-lazin-1,4-dion

Luminol

HCID 10638

Grundinformationen

CAS
521-31-3
Standard-SMILES
Nc1cccc2c(=O)[nH][nH]c(=O)c12
InChIKey
HWYHZTIRURJOHG-UHFFFAOYSA-N
Summenformel
C8H7N3O2
Durchschnittliche Molmasse
177,16 g/mol
Monoisotopische Masse
177,05382646

Überblick

O-aminophthalyl hydrazide appears as yellow crystals or light beige powder. (NTP, 1992)

Namen und Bezeichner

Bevorzugter Name
Luminol
IUPAC
5-amino-2,3-dihydrophthalazine-1,4-dione
Lokaler Name
5-Amino-1,2,3,4-tetrahydrophtha-lazin-1,4-dion
Englischer Name
Luminol
Summenformel
C8H7N3O2
Molmasse
177.16

Namen und Synonyme

LUMINOL521-31-35-Amino-2,3-dihydro-1,4-phthalazinedione3-Aminophthalic hydrazide1,4-Phthalazinedione, 5-amino-2,3-dihydro-o-aminophthalylhydrazide3-Aminophthalic acid hydrazideDTXSID5024504o-Aminophthaloyl hydrazide5EXP385Q4FNSC-5064DTXCID004504
Weitere Namen anzeigen
5-aminophthalazine-1,4-diol3-Aminophthalhydrazide (Luminol)Luminol and sodium saltuminoLRuminosLuMinol 97%
RefChem:5965208-309-43-Aminophthalhydrazide5-amino-2,3-dihydrophthalazine-1,4-dione5-Amino-1,2,3,4-tetrahydrophthalazine-1,4-dioneMFCD000068903-AminophthalylhydrazideNSC 5064

Datenbank-Bezeichner

CAS
521-31-3
PubChem CID
10638
DTXSID
DTXSID5024504
ChEMBL
CHEMBL442329
UNII
5EXP385Q4F
EC Number
208-309-4
Nikkaji
J9.432C

Eigenschaften

Berechnete Struktureigenschaften

XLogP
0,3
Polarare Oberfläche (TPSA)
84,2 Ų
H-Brücken-Donoren
3
H-Brücken-Akzeptoren
3
Frei drehbare Bindungen
0
Schwere Atome
13

Experimentelle und physikochemische Eigenschaften

Chemical ClassesDyes -> Indicator Dyes
SpringerMaterials PropertiesLuminescence
Solubilityless than 1 mg/mL at 66 °F (NTP, 1992)
Melting Point606 to 608 °F (NTP, 1992)
Physical Description · 2 Einträge

O-aminophthalyl hydrazide appears as yellow crystals or light beige powder. (NTP, 1992)

Yellow or light beige solid; [CAMEO] Light yellow powder; [Sigma-Aldrich MSDS]

Physikochemische Eigenschaften

Schmelzpunkt
300 °C · >300 °C (lit.)
Siedepunkt
309.07 °C · 309.07°C (rough estimate)
Dichte
1.3393 · 1.3393 (rough estimate)
Brechungsindex
1.65 · 1.6500 (estimate)
storage temp.
30 °C · Store below +30°C.
Löslichkeit
Insoluble in water, soluble in dimethyl sulfoxide.

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 5 Einträge

This chemical does not meet GHS hazard criteria for 1.7% (1 of 59) of reports.

Warning

H302 (15.3%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 59 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory Information · 2 Einträge

Chemical: 1,4-Phthalazinedione, 5-amino-2,3-dihydro-

5-Amino-2,3-dihydro-1,4-phthalazinedione: Does not have an individual approval but may be used under an appropriate group standard

Fire HazardsFlash point data for this material are not available, but it is probably combustible. (NTP, 1992)
Health HazardsACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes. (NTP, 1992)
Hazards SummaryAcute oral lethal-dose > 500 mg/kg; [RTECS] A skin and strong eye irritant; [Sigma-Aldrich MSDS]
Reactive GroupAmides and Imides
Reactivity ProfileOxidation of O-AMINOPHTHALYL HYDRAZIDE is accompanied by a striking emission of light. (NTP, 1992). It is incompatible with strong oxidizing agents, strong reducing agents, strong acids, and strong bases [Sigma-Aldrich MSDS].

Sicherheit und Schutzausrüstung

Fire FightingFires involving this material can be controlled with a foam, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 Eintrag

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 Eintrag

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then dampen the solid spill material with toluene, then transfer the dampened material to a suitable container. Use absorbent paper dampened with toluene to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash all contaminated surfaces with toluene followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Personal Protective Equipment (PPE) · 1 Eintrag

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Sicherheitsdaten

F
10-23
wgk
3
tsca
TSCA listed
hs_code
29339990
RTECS-Nr.
TH8890060
risk_code
36/37/38-22-20/21/22

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological Classification · 2 Einträge

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)

Compound such as LUMINESCENT PROTEINS that cause or emit light (PHYSICAL LUMINESCENCE).

Verwendung und Herstellung

UsesUsed to detect copper, iron, peroxides, and cyanides--produces light when oxidized; [Merck Index]
General Manufacturing Information1,4-Phthalazinedione, 5-amino-2,3-dihydro-: ACTIVE
Anwendungen · 1 Eintrag

VerwendenLuminol is used in the detection of copper, iron, peroxides and cyanides. It exhibits chemiluminescence and utilized to measure opsonic and phagocytic function. It acts as a biological sensor and involved in the detection of polymorphonuclear leukocytes response in a patient with a myeloperoxidase deficiency. Further, it is used as a forensic test for blood.

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