Grundinformationen
- CAS
521-31-3- Standard-SMILES
Nc1cccc2c(=O)[nH][nH]c(=O)c12- InChIKey
HWYHZTIRURJOHG-UHFFFAOYSA-N- Summenformel
- C8H7N3O2
- Durchschnittliche Molmasse
- 177,16 g/mol
- Monoisotopische Masse
- 177,05382646
Überblick
O-aminophthalyl hydrazide appears as yellow crystals or light beige powder. (NTP, 1992)
Namen und Bezeichner
- Bevorzugter Name
- Luminol
- IUPAC
- 5-amino-2,3-dihydrophthalazine-1,4-dione
- Lokaler Name
- 5-Amino-1,2,3,4-tetrahydrophtha-lazin-1,4-dion
- Englischer Name
- Luminol
- Summenformel
- C8H7N3O2
- Molmasse
- 177.16
Namen und Synonyme
Weitere Namen anzeigen
Datenbank-Bezeichner
- CAS
521-31-3- PubChem CID
- 10638
- DTXSID
DTXSID5024504- ChEMBL
CHEMBL442329- UNII
- 5EXP385Q4F
- EC Number
- 208-309-4
- Nikkaji
- J9.432C
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 0,3
- Polarare Oberfläche (TPSA)
- 84,2 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 3
- Frei drehbare Bindungen
- 0
- Schwere Atome
- 13
- Formalladung
- 0
- Komplexität
- 254
Experimentelle und physikochemische Eigenschaften
Physical Description
O-aminophthalyl hydrazide appears as yellow crystals or light beige powder. (NTP, 1992)
Yellow or light beige solid; [CAMEO] Light yellow powder; [Sigma-Aldrich MSDS]
Physikochemische Eigenschaften
- Schmelzpunkt
- 300 °C · >300 °C (lit.)
- Siedepunkt
- 309.07 °C · 309.07°C (rough estimate)
- Dichte
- 1.3393 · 1.3393 (rough estimate)
- Brechungsindex
- 1.65 · 1.6500 (estimate)
- storage temp.
- 30 °C · Store below +30°C.
- Löslichkeit
- Insoluble in water, soluble in dimethyl sulfoxide.
- pka
- 10.5 · (Calcd.) 10.50 ± 0.20;;0.58 ± 0.20(at 25℃)
- Aggregatzustand
- Powder
- Farbe
- Dark green to dark blue-purple
- Wasserlöslichkeit
- 0.1 g/100 · <0.1 g/100 mL at 19 ºC
- Merck
- 14 · 14,5600
- BRN
- 383929 · 383929
- Stabilität
- Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, strong bases, strong reducing agents. Emits light on reaction with oxidizers.
- Major Application
- Night vision devices, identification of product forgeries, determination of nitride in food, analytical chemistry, pharmaceuticals, iodine in biological materials, evaluating phagocytes, detecting tumors, DNA, biosensors, assay of fungi, bacteria, yeasts, assay of lipase activity
- InChI
- 1S/C8H7N3O2/c9-5-3-1-2-4-6(5)8(13)11-10-7(4)12/h1-3H,9H2,(H,10,12)(H,11,13)
- InChIKey
- HWYHZTIRURJOHG-UHFFFAOYSA-N
- SMILES
- Nc1cccc2C(=O)NNC(=O)c12
- LogP
- -0.245 · -0.245 (est)
- CAS Datenbank
- 521 · 521-31-3(CAS DataBase Reference)
- NIST chemische Informationen
- 3 · 3-Aminophthalhydrazide(521-31-3)
- EPA chemische Informationen
- Luminol (521-31-3)
Sicherheit und Regulatorisches
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 1.7% (1 of 59) of reports.
Warning
H302 (15.3%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 59 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
Chemical: 1,4-Phthalazinedione, 5-amino-2,3-dihydro-
5-Amino-2,3-dihydro-1,4-phthalazinedione: Does not have an individual approval but may be used under an appropriate group standard
Sicherheit und Schutzausrüstung
First Aid
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
Nonfire Spill Response
SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then dampen the solid spill material with toluene, then transfer the dampened material to a suitable container. Use absorbent paper dampened with toluene to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash all contaminated surfaces with toluene followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Personal Protective Equipment (PPE)
RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)
Sicherheitsdaten
- F
- 10-23
- wgk
- 3
- tsca
- TSCA listed
- hs_code
- 29339990
- RTECS-Nr.
- TH8890060
- risk_code
- 36/37/38-22-20/21/22
- hazard_code
- Xi,Xn
- safety_code
- 26-36/37-37/39-36
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
Compound such as LUMINESCENT PROTEINS that cause or emit light (PHYSICAL LUMINESCENCE).
Verwendung und Herstellung
Anwendungen
VerwendenLuminol is used in the detection of copper, iron, peroxides and cyanides. It exhibits chemiluminescence and utilized to measure opsonic and phagocytic function. It acts as a biological sensor and involved in the detection of polymorphonuclear leukocytes response in a patient with a myeloperoxidase deficiency. Further, it is used as a forensic test for blood.
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