Gluconic Acid

Cosmetic ingredients (Gluconic Acid) -> CIR (Cosmetic Ingredient Review)

Humectant; Solvent; Buffering

1.24 @ 25 °C/4 °C

1.23 g/cm³

1.24 @25 °C

NEEDLES FROM ETHANOL & ETHER

CRYSTALS

FREELY SOL IN WATER; SLIGHTLY SOL IN ALC, INSOLUBLE IN ETHER AND MOST OTHER ORGANIC SOLVENTS

316 mg/mL at 25 °C

Solubility in water, g/100ml at 25 °C: 100 (good)

131 °C

113 - 118 °C

131 °C

131 °C

SPECIFIC OPTICAL ROTATION: -3.49 TO +12.95 DEG @ 25 °C/D (WATER); MUTAROTATORY; SADTLER REFERENCE NUMBER: 8335 (IR, PRISM)

SPECIFIC OPTICAL ROTATION: -6.7 DEG @ 20 °C/D (CONCN= 1 G/100 ML WATER)

Dry Powder; Liquid; Liquid; Other Solid

Colourless to light yellow, clear syrupy liquid

Light brown solid; Commercial product is 50% aqueous solution; [Hawley] 50% aqueous solution: Pale yellow liquid; [MSDSonline]

Solid

WHITE CRYSTALLINE POWDER.

This chemical does not meet GHS hazard criteria for 33% (257 of 779) of reports.

Warning

H315 (60.6%): Causes skin irritation [Warning Skin corrosion/irritation]

P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)

Aggregated GHS information provided per 779 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Chemical: D-Gluconic acid

D-Gluconic acid is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of D-Gluconic acid are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 16-07-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/1957

D-Gluconic acid: Does not have an individual approval but may be used under an appropriate group standard

Emergency treatment: Irritants; [HSDB] No significant adverse effects in chronic studies of animals; Reproductive studies negative; No data available on carcinogenicity or inhalation toxicity; [OECD SIDS: Gluconic acid and its derivatives - 2004] 50% aqueous solution: A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis; [MSDSonline]

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Gluconic acid is found on List D. Case No: 4043; Pesticide type: Antimicrobial; Case Status: No products containing the pesticide are actively registered ... The case /is characterized/ as "cancelled." Under FIFRA, pesticide producers may voluntarily cancel their registered products. EPA also may cancel pesticide registrations if registrants fail to pay required fees or make/meet certain reregistration commitments, or if EPA reaches findings of unreasonable adverse effects.; Active ingredient (AI): Gluconic acid; AI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled."

Gluconic acid (and sodium salt) is exempted from the requirement of a tolerance when used as a sequestrant in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only.

Fresh air, rest.

Rinse skin with plenty of water or shower.

Rinse with plenty of water (remove contact lenses if easily possible).

Rinse mouth.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.

Gluconic acid (and sodium salt) is exempted from the requirement of a tolerance when used as a sequestrant in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only.

18 [mg/m3]

200 [mg/m3]

1200 [mg/m3]

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Gluconic acid is found on List D. Case No: 4043; Pesticide type: Antimicrobial; Case Status: No products containing the pesticide are actively registered ... The case /is characterized/ as "cancelled." Under FIFRA, pesticide producers may voluntarily cancel their registered products. EPA also may cancel pesticide registrations if registrants fail to pay required fees or make/meet certain reregistration commitments, or if EPA reaches findings of unreasonable adverse effects.; Active ingredient (AI): Gluconic acid; AI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled."

Gluconic acid (and sodium salt) is exempted from the requirement of a tolerance when used as a sequestrant in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only.

CIR ingredient: Gluconic Acid

Primary acid in honey; Used in pharmaceutical and food products, for cleaning and pickling metals, as a sequestrant, in paint strippers, and in alkaline rust removers; [Hawley] Used as a chelating agent, high alkalinity bottle cleanser, and finish remover; Used in the tanning and textile industries; [Merck Index] Important intermediate in carbohydrate metabolism in mammals; Used for industrial cleaning, metal surface treatment, textile bleach stabilizing, aluminum processing, and as a chelating agent in cement set retarding, cleaning products, personal care products, pharmaceuticals, and foods; [OECD SIDS: Gluconic acid and its derivatives - 2004]

Aluminum Producing [Category: Industry]

For Gluconic acid (USEPA/OPP Pesticide Code: 000104) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

The active ingredient is no longer contained in any registered pesticide products ... "cancelled."

IN DAIRY INDUST TO PREVENT MILKSTONE; IN BREWERIES TO PREVENT BEERSTONE; LATENT ACID CATALYST FOR ACID COLLOID RESINS, PARTICULARLY IN TEXTILE PRINTING COMPONENT OF MANY CLEANING COMPOUNDS... /GLUCONOLACTONE/

MAY BE PREPARED FROM GLUCOSE BY ELECTROLYTIC OXIDN IN ALKALINE MEDIUM; BY CHEM OXIDN WITH HYPOBROMITES

BY HYDROLYSIS OF ALPHA-D-GLUCOSE WITH BROMINE PLUS H2SO4; BY GAMMA-IRRADIATION OF D-GLUCOSE;

AT PRESENT PRODUCED IN COMMERCIAL QUANTITIES BY FERMENTATIVE OXIDN OF ALDEHYDE GROUP IN GLUCOSE FROM CORN USING ASPERGILLUS NIGER, ASPERGILLUS FUMARICUS, ACETOBACTER ACETI, PENICILLIUM CHRYSOGENUM, & OTHER PENICILLIA.

CANNIZZARO REACTION ON GLUCOSE UNDER ALKALINE CONDITIONS FORMS SORBITOL AND GLUCONIC ACID

For more Methods of Manufacturing (Complete) data for GLUCONIC ACID (6 total), please visit the HSDB record page.

BECAUSE OF DIFFICULTIES OF PREPARING SOLID CRYSTAL PRODUCT, GLUCONIC ACID OF COMMERCE IS 50% AQ SOLN...

GRADES: TECHNICAL, 50% SOLN.

Information on 24 consumer products that contain D-Gluconic acid in the following categories is provided:

Information on 4 consumer products that contain Gluconic acid in the following categories is provided:

EPA Safer Chemical Functional Use Classes -> Chelating Agents;Processing Aids and Additives

Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern

Food additives

Food Additives -> ACID; ACIDITY_REGULATOR; RAISING_AGENT; SEQUESTRANT -> JECFA Functional Classes

Cosmetics -> Humectant; Solvent; Buffering

Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing

D-Gluconic acid: ACTIVE

IT IS CHIEF ACID IN HONEY.