Kupferdi-D-gluconat

Cosmetic ingredients (Copper Gluconate) -> CIR (Cosmetic Ingredient Review)

Skin conditioning; Skin protecting

Light blue to bluish-green, odorless crystals and crystalline powder. Astringent taste. 30 g soluble in 100 ml water at 25 °C; slightly sol in alcohol; practically insol in most org solvents. /Hydrate/

Sol in water; insol in acetone, alcohol, ether

This chemical does not meet GHS hazard criteria for 0.4% (1 of 251) of reports.

Warning

H302 (99.2%): Harmful if swallowed [Warning Acute toxicity, oral]

P260, P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 251 reports by companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Chemical: Copper, bis(D-gluconato)-

Regulation (EC) No 1107/2009 (amended)

REACH registered substance: Copper di-D-gluconate (EC: 208-408-2)

Copper gluconate: Does not have an individual approval but may be used under an appropriate group standard

Trace minerals added to animal feeds. These substances added to animal feeds as nutritional dietary supplements are generally recognized as safe when added are levels consistent with good feeding practice. Element: Copper; Source compound: copper gluconate. (All substances listed may be in anhydrous or hydrated form.)

Substance added directly to human food affirmed as generally recognized as safe (GRAS).

This substance is generally recognized as safe for use at a level not exceeding 0.005 percent in accordance with good manufacturing practice.

Copper is mainly absorbed through the gastrointestinal tract, but it can also be inhalated and absorbed dermally. It passes through the basolateral membrane, possibly via regulatory copper transporters, and is transported to the liver and kidney bound to serum albumin. The liver is the critical organ for copper homoeostasis. In the liver and other tissues, copper is stored bound to metallothionein, amino acids, and in association with copper-dependent enzymes, then partitioned for excretion through the bile or incorporation into intra- and extracellular proteins. The transport of copper to the peripheral tissues is accomplished through the plasma attached to serum albumin, ceruloplasmin or low-molecular-weight complexes. Copper may induce the production of metallothionein and ceruloplasmin. The membrane-bound copper transporting adenosine triphosphatase (Cu-ATPase) transports copper ions into and out of cells. Physiologically normal levels of copper in the body are held constant by alterations in the rate and amount of copper absorption, compartmental distribution, and excretion. (L277, L279)

CIR ingredient: Copper Gluconate

Used in dietary supplements, oral deodorants, and feed additives; [HSDB] Used as a synergist and nutritional supplement for foods; [FDA]

Farming (Feed Additives) [Category: Industry]

For Cupric gluconate (USEPA/OPP Pesticide Code: 024405) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

In dietary supplements as a readily assimilable form of copper; as oral deodorant

Feed additive

Prepd from gluconic acid and basic cupric carbonate: Suzuki et al, Japan pat 2889('63) (to Dainippon), C.A. 59, 11264c (1963)

Reaction of gluconic acid solutions with basic copper(II) carbonates or copper(II) hydroxide

Copper carbonate, basic/copper hydroxide + gluconic acid (salt formation)