Grundinformationen
- CAS
532-43-4- Standard-SMILES
Cc1ncc(C[n+]2csc(CCO)c2C)c(N)n1.O=[N+]([O-])[O-]- InChIKey
UIERGBJEBXXIGO-UHFFFAOYSA-N- Summenformel
- C12H17N4OS.NO3
- Durchschnittliche Molmasse
- 327,36 g/mol
- Monoisotopische Masse
- 327,10012502
Namen und Bezeichner
- Bevorzugter Name
- Thiamine Nitrate
- IUPAC
- 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol nitrate
- Lokaler Name
- Thiaminnitrat
- Englischer Name
- Thiamine nitrate
- Summenformel
- C12H17N5O4S
- Molmasse
- 327.36
Namen und Synonyme
thiamine nitrate532-43-4THIAMINE MONONITRATEVitamin B1 mononitrateAneurine mononitrateBetabion mononitrateThiamine nitrate (salt)thiamin mononitrateThiamini mononitrasDTXSID4038762Vitamin b1 (as thiamine nitrate)Mononitrate, Thiamine
Weitere Namen anzeigen
Vitamin B1 MonoThiaMine MonohydrateVITAMIN B1 NITRATEThiamine nitrate CRSvitamin Bl mononitrateThia532-43-4mine NitrateVitamin B1 Nitrate 〔Thiamine Nitrate〕
8K0I04919XThiamine mononitrate (USP)Thiamine mononitrate [USP]DTXCID20187623-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium nitrate3-((4-amino-2-methylpyrimidin-5-yl)methyl)-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium nitrateRefChem:1892523-(4-Amino-2-methylpyrimidin-5-ylmethyl)-5-(2-hydroxyethyl)-4-methylthiazolium nitrate
Datenbank-Bezeichner
- CAS
532-43-4
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 167 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 8
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 22
- Formalladung
- 0
- Komplexität
- 287
Experimentelle und physikochemische Eigenschaften
CosmeticsSkin conditioning
Food AdditivesNUTRIENT SUPPLEMENT -> FDA Substance added to food
Physikochemische Eigenschaften
- Schmelzpunkt
- 374 · 374-392 °C
- Dichte
- 1.58 g/cm3 · 1.58 g/cm3
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- Sparingly soluble in water, freely soluble in boiling water, slightly soluble in alcohol and in methanol.
- Aggregatzustand
- solid
- pka
- 4.8 · 4.8(at 25℃)
- Farbe
- White to Off-White
- Geruch (Odor)
- wh. cryst. or cryst. powd., sl. char. odor
- Biologische Quelle
- synthetic
- Merck
- 14 · 14,9295
- BRN
- 3857790 · 3857790
- Stabilität
- Stable. Incompatible with strong oxidizing agents.
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 100% (67 of 67) of all reports.
Not Classified
Aggregated GHS information provided per 67 reports by companies from 2 notifications to the ECHA C&L Inventory.
Gefahrenhinweise
Regulatory Information
Chemical: Thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-, nitrate (salt)
Regulation (EC) No 1831/2003 (amended)
Thiamine mononitrate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationEvaluation - Chemicals that are unlikely to require further regulation to manage risks to environment
Hazard Classes and CategoriesNot Classified
Sicherheitsdaten
- wgk
- 1
- tsca
- TSCA listed
- hs_code
- 29362200
- RTECS-Nr.
- XI7400000
- safety_code
- 22-24/25
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological ClassificationA group of water-soluble vitamins, some of which are COENZYMES.
Verwendung und Herstellung
Use ClassificationCosmetics -> Skin conditioning
General Manufacturing InformationThiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-, nitrate (1:1): ACTIVE
Anwendungen
BeschreibungThiamine is a water-soluble vitamin with antioxidant, neuroprotective, and anxiolytic properties. It inhibits lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro when used at concentrations ranging from 1 to 100 μM. In vivo, thiamine (100 mg/kg) reduces hepatic levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), lipid peroxidation, and protein damage in a rat model of acute ethanol intoxication. It reverses predator stress-induced suppression of hippocampal neurogenesis and decreases the latency of step-down from a platform, indicating anxiolytic-like activity in mice. Thiamine (8.5 mg/100 g food) reduces neurodegeneration and increases survival in Slc19a3-/- mice, a model of thiamine metabolism dysfunction syndrome-2 (THMD-2).
VerwendenThiamine Nitrate is an orally administered vitamin. Thiamine is a essential nutrient required for carbohydrate metabolism and is involved in nerve function.
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