2-Desoxy-D-glucose

This chemical does not meet GHS hazard criteria for 100% (2 of 2) of all reports.

Not Classified

Aggregated GHS information provided per 2 reports by companies from 1 notifications to the ECHA C&L Inventory.

Chemical: D-arabino-Hexose, 2-deoxy-

D-arabino-Hexose, 2-deoxy-: Does not have an individual approval but may be used under an appropriate group standard

2-DEOXYGLUCOSE INJECTED INTRAPERITONEALLY IN RATS IN LARGE DOSES CAUSED CHANGES IN THE ELECTRORETINOGRAM CONSISTING OF A DECR IN BOTH ALPHA- AND BETA-WAVES. THE EFFECT WAS ANTAGONIZED BY D-GLUCOSE.

SIMULTANEOUS ADMIN OF GLUCOSE @ DOSE EXCEEDING ITS MAX TUBULAR TRANSPORT CAPACITY INHIBITED TUBULAR REABSORPTION OF 2-DEOXYGLUCOSE. THUS, THE PROCESS OF TUBULAR REABSORPTION IS PROBABLY THE SAME AS THAT FOR GLUCOSE.

IN ANESTROUS SHEEP, 2-DEOXYGLUCOSE INFUSION INHIBITED LH RELEASE INDUCED BY ESTRADIOL BUT NOT BY LH-RH.

2-DEOXY-D-GLUCOSE INHIBITED REPAIR OF POTENTIALLY LETHAL DAMAGE INDUCED BY X-RAYS IN MOUSE EHRLICH ASCITES TUMOR CELLS.

For more Interactions (Complete) data for 2-DEOXY-D-GLUCOSE (6 total), please visit the HSDB record page.

2-DEOXYGLUCOSE INJECTED INTRAPERITONEALLY IN RATS IN LARGE DOSES CAUSED CHANGES IN THE ELECTRORETINOGRAM CONSISTING OF A DECR IN BOTH ALPHA- AND BETA-WAVES.

...120 MG/DAY /GIVEN TO RAT/ FROM THE 9TH THROUGH THE 20TH GESTATIONAL DAY... RESORPTIONS WERE 69% AND THE SURVIVING FETUSES WERE ALL MALFORMED. ANOPHTHALMIA, CLEFT LIP AND PALATE AND LESIONS OF THE EXTREMITIES WERE OBSERVED. ...GAVE 1 G/KG ON DAYS 8, 9, 10 OR 11 & FOUND NO MALFORMATIONS IN SURVIVING RAT FETUSES.

2-DEOXY-D-GLUCOSE (DGLC) SELECTIVELY INHIBITED VIRUS DNA SYNTHESIS IN HUMAN EMBRYONIC LUNG CELLS INFECTED WITH HUMAN CYTOMEGALOVIRUS (HCMV). THE EFFECTIVE CONCN OF DGLC WAS APPROX 10-FOLD HIGHER IN CULTURE MEDIUM CONTAINING GLUCOSE INSTEAD OF SODIUM PYRUVATE. VIRUS DNA SYNTHESIS COULD BE SELECTIVELY INHIBITED BY ADDN OF DGLC EVEN AFTER INITIATION OF HCMV DNA REPLICATION. APPARENTLY, DGLC INTERFERES WITH THE FUNCTION OF AN EARLY CHROMATIN-ASSOCIATED GLYCOPROTEIN ESSENTIAL FOR VIRUS DNA SYNTHESIS.

2-DEOXY-D-GLUCOSE (0.3-1.2 MOL) INJECTED INTO THE 3RD VENTRICLE OF RATS DEPRESSED APPETITE FOR 72 HR. THE BLOOD SUGAR WAS INCR FOR 48 HR, WHILE FREE FATTY ACID INITIALLY INCR BUT DECR BY 24 HR.

For more Non-Human Toxicity Excerpts (Complete) data for 2-DEOXY-D-GLUCOSE (7 total), please visit the HSDB record page.

Solid tumors have hypoxic areas with slow growing cells that are resistant to chemotherapy, which attacks rapidly dividing cells. In the hypoxic area of the tumor, the cells rely on anaerobic glycolysis to produce energy in the form of ATP while non-tumor cells can rely on additional pathways such as fatty acid and amino acid metabolism to produce ATP. 2-deoxyglucose is an inhibitor of glycolysis because as a modified glucose molecule (it has a hydrogen at the carbon 2 position instead of a hydroxyl group), it is unable to complete the glycolysis process, and as such will hinder the survival of slow growing cancer cells. Regarding 2-deoxyglucose's antiviral activity, it prevents the glycosylation of specific proteins and lipids as well as prevents proper penetration of the virus into the target cells. In temporal lobe epilepsy, 2-deoxyglucose represses the overactive brain-derived neurotrophic factor (BDNF) promoter and prevents the increased expression of BDNF protein and TrkB receptor (BDNF's receptor) that is observed in epileptic patients.

Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033)

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.

WHEN THE RENAL EXCRETION OF 2-DEOXYGLUCOSE WAS STUDIED IN DOGS AND RATS BY CONVENTIONAL CLEARANCE AND STOP-FLOW TECHNIQUES, IT WAS REABSORBED BY THE RENAL TUBULES AT AN AVG OF 68-89% OF THE FILTERED LOADS AND THE REABSORPTION SITE WAS IN THE PROXIMAL TUBULES.

2-DEOXYGLUCOSE IS A GLUCOSE ANTIMETABOLITE, INHIBITING GLYCOLYSIS; IT IS A WIDELY USED RESEARCH TOOL TO STUDY GLUCOSE-DEPENDENT OR -MEDIATED REACTIONS

RESEARCH CHEMICAL

MEDICATION (VET)

(1979) No Data

(1981) No Data

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D-arabino-Hexose, 2-deoxy-: ACTIVE

THE DEOXYSUGARS SUCH AS 2-DEOXYGLUCOSE ARE POTENT HERBICIDES. 2-DEOXYGLUCOSE SPRAYED AT 100 G/ACRE COMPLETELY CONTROLLED PLANTAGO ASIATICA IN AGROPYRON KAMOCHI AND ELEUSINE INDICA.