HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methamphetamin
crystal · LEVMETAMFETAMINE · Methylamphetamine · Metamfetamine · Metamphetamine · N-Methylamphetamine · (S)-N-methyl-1-phenylpropan-2-amine · (2S)-N-methyl-1-phenylpropan-2-amine
Identifikatoren & physikalische Daten
| CAS No. | 537-46-2 |
|---|---|
| Summenformel | C10H15N |
| Durchschnittliche Molmasse | 149,23 g/mol |
| Monoisotopische Masse | 149,12044948 g/mol |
| SMILES | CN[C@@H](C)Cc1ccccc1 |
| InChIKey | MYWUZJCMWCOHBA-VIFPVBQESA-N |
| PubChem CID | 10836 |
| ChEMBL | CHEMBL1201201 |
| ChEBI | CHEBI:6809 |
| EC No. | 208-668-7 |
| DTXSID | DTXSID8037128 |
| Lokaler Name | Methamphetamin |
Chemische & physikalische Eigenschaften
| XLogP | 2,1 |
|---|---|
| Polarare Oberfläche (TPSA) | 12 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 1 |
| Frei drehbare Bindungen | 3 |
| Schwere Atome | 11 |
| Formalladung | 0 |
| Komplexität | 95 |
| Arzneimittel | DEA NFLIS-Drug Category -> Phenethylamines (Amphetamines) (S)Pharmaceuticals -> Illicit drugsPharmaceuticals -> Synthetic Cannabinoids or Psychoactive CompoundsPharmaceuticals -> Listed in ZINC15 |
| pH | A saturated soln in water is alkaline to litmus |
| SpringerMaterials Properties | Boiling point |
| LogP (Verteilungskoeffizient) | log Kow = 2.07 |
| Geruch | Characteristic odor resembling geranium leavesOdorless |
| Geschmack | Bitter-tasting |
| Color/Form | Clear, colorless liquidWhite crystalline powder |
| Löslichkeit | In water, 0.5 g/mLSoluble in ethanol, diethyl etherMiscible with chloroform9.28e-01 g/L |
| Flammpunkt | 9.7 °C (49.5 °F) - closed cup9℃ |
| Human Drugs | Breast FeedingLactationMilk, HumanStreet DrugsSympathomimeticsDopamine AgentsCentral Nervous System StimulantsAdrenergic AgentsWakefulness-Promoting AgentsPharmaceuticals |
| Siedepunkt | 212 °C230.33°C (estimate) |
| Decomposition | When heated to decomposition it emits toxic vapors of Nitric oxides. |
| Schmelzpunkt | 143°C (estimate) |
| Dichte | 0.9285 (estimate) |
| Brechungsindex | 1.5105 (estimate) |
| Lagerbedingungen | 2-8°C |
| pKa (Säurekonstante) | 10.38±0.10(Predicted) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH301 (97.6%): Toxic if swallowed [Danger Acute toxicity, oral]P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 42 reports by companies from 3 notifications to the ECHA C&L Inventory.H225: Highly Flammable liquid and vapor [Danger Flammable liquids] |
|---|---|
| Regulatorische Informationen | Status: Active Update: 23-10-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/27285 |
| FDA-Anforderungen | The Approved Drug Products with Therapeutic Equivalence Evaluations identifies currently marketed prescription drug products, including methamphetamine hydrochloride, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act. /Methamphetamine hydrochloride/Schedule II shall consist of the drugs and other substances, by whatever official name, common or usual name, chemical name, or brand name designated, listed in this section. Each drug or substance has been assigned the DEA Controlled Substances Code Number set forth opposite it. ... (d) Stimulants. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances having a stimulant effect on the central nervous system: Methamphetamine, its salts, isomers, and salts of its isomers (DEA Code Number: 1105) is included on this list. /Methamphetamine, its salts, isomers, and salts of its isomers/ |
| Special Reports | DHHS/NIDAResearch Monograph Series 52: Testing Drugs for Physical Dependence Potential and Abuse Liability (1984) DHHS Pub No. (ADM)87-1332Research Monograph Series 54: Mechanisms of Tolerance and Dependence (1984) DHHS Pub No. (ADM)88-1330Research Monograph Series 56: Etiology of Drug Abuse: Implications for Prevention (1987) DHHS Pub No. (ADM)87-1335Research Monograph Series 59: Current Research on the Consequences of Maternal Drug Abuse (1985) DHHS Pub No. (ADM)85-1400For more Special Reports (Complete) data for d-METHAMPHETAMINE (8 total), please visit the HSDB record page. |
| Hazard Classes and Categories | Acute Tox. 3 (97.6%) |
Anwendungen & Verwendung
Verwenden
Nasal decongestant.