Sarkosin
Sar · Methylglycine · N-METHYLGLYCINE · H-SAR-OH · Sarcosin · SAR-OH · N-ME-GLY-OH · Methyl-glycocoll
Identifikatoren & physikalische Daten
| CAS No. | 107-97-1 |
|---|---|
| Summenformel | C3H7NO2 |
| Durchschnittliche Molmasse | 89,09 g/mol |
| Monoisotopische Masse | 89,04767846 g/mol |
| SMILES | CNCC(=O)O |
| InChIKey | FSYKKLYZXJSNPZ-UHFFFAOYSA-N |
| PubChem CID | 1088 |
| ChEMBL | CHEMBL304383 |
| ChEBI | CHEBI:15611 |
| EC No. | 203-538-6 |
| DTXSID | DTXSID1047025 |
| Lokaler Name | Sarkosin |
Chemische & physikalische Eigenschaften
| XLogP | -2,8 |
|---|---|
| Polarare Oberfläche (TPSA) | 49,3 |
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 3 |
| Frei drehbare Bindungen | 2 |
| Schwere Atome | 6 |
| Formalladung | 0 |
| Komplexität | 52,8 |
| Stoffklassen | Biological Agents -> Amino Acids and Derivatives |
| Arzneimittel | Pharmaceuticals -> Listed in ZINC15 |
| Kosmetika | Cosmetic ingredients (Cocoyl Sarcosine) -> CIR (Cosmetic Ingredient Review)CleansingSurfactantSkin conditioningPersonal care product |
| LogP (Verteilungskoeffizient) | -2.78 |
| Löslichkeit | greater than or equal to 100 mg/mL at 61 °F (NTP, 1992)300.0 mg/mL5.6 [ug/mL] (The mean of the results at pH 7.4)H2O: 1 M at 20 °C1480 g/L (20 ºC) |
| Schmelzpunkt | 406 °F (Decomposes) (NTP, 1992)208 °C208-212 °C (dec.)(lit.) |
| Dampfdruck | 0.00000017 [mmHg] |
| Food Contact Substances | FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR |
| Physical Description | Deliquescent crystals or powder. Has a sweetish taste. (NTP, 1992)Deliquescent solid[Merck Index] Cream-colored hygroscopic solid[NTP] White odorless crystalline powder[Alfa Aesar MSDS] |
| Siedepunkt | 165.17°C (rough estimate) |
| Dichte | 1.1948 (rough estimate) |
| Brechungsindex | 1.4368 (estimate) |
| Flammpunkt | >100℃ |
| Lagerbedingungen | Store below +30°C. |
| pKa (Säurekonstante) | 2.21(at 25℃) |
| Aggregatzustand | Crystals or Powder |
| Farbe | Colorless or white to yellow |
| pH | 6.1 (100g/l, H2O, 20℃) |
| Merck | 14,8373 |
| BRN | 1699442 |
| Hauptanwendungen | peptide synthesis |
| Kosmetik-Inhaltsstoffe Funktionen | SKIN CONDITIONING |
| InChI | 1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) |
| InChIKey | FSYKKLYZXJSNPZ-UHFFFAOYSA-N |
| SMILES | CNCC(O)=O |
| CAS Datenbank | 107-97-1(CAS DataBase Reference) |
| NIST chemische Informationen | Sarcosine(107-97-1) |
| EPA chemische Informationen | Sarcosine (107-97-1) |
| CAS Number Unlabeled | 107-97-1 |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 98.7% (149 of 151) of all reports.Not ClassifiedAggregated GHS information provided per 151 reports by companies from 3 notifications to the ECHA C&L Inventory. |
|---|---|
| Regulatorische Informationen | Chemical: Glycine, N-methyl-Status: Active Update: 20-12-2016 https://echa.europa.eu/registration-dossier/-/registered-dossier/18702Glycine, N-methyl-: Does not have an individual approval but may be used under an appropriate group standard |
| Weitere Sicherheitsinformationen | Evaluation - Chemicals that are unlikely to require further regulation to manage risks to environment |
| Brandgefahren | Flash point data for this chemical are not available. It is probably combustible. (NTP, 1992) |
| Gefahrenübersicht | Causes analgesia in acute intravenous studies of mice[RTECS] May cause irritation[Alfa Aesar MSDS] |
| Reaktive Gruppe | Acids, Carboxylic |
| Reactivity Profile | SARCOSINE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). This chemical is incompatible with acids. (NTP, 1992). |
| Air and Water Reactions | Deliquescent. Water soluble. |
| Hazard Classes and Categories | Not Classified |
| Brandbekämpfung | Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992) |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
Anwendungen & Verwendung
Verwenden
Sarcosine can improve people's intelligence, especially for exams such as the students need to temporarily increase the effectiveness of intelligence is more obvious. sarcosine can increase muscle strength and anaerobic explosiveness.To prevent damage caused by the brain injury. Sarcosine can effectively improve athletic performance,power, and shorten muscle recovery time.
Verwenden
Sarcosine is an important component for the production of the amino acid glycine and a byproduct of glycine breakdown. In the body, it is produced by converting dietary choline to glycine or breaking down methionine into glycine. It can also be synthesized in the laboratory with chloroacetic acid and methylamine. Sarcosine has a unique mild sweetness. Since a derivative of creatine helps prevent tooth decay and causes foam, it acts as an ingredient in toothpaste. Sarcosine can also be used as a drug, and research over the past 20 years has revealed its role in treating mental health disorders such as schizophrenia and depression.