HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,2-Dichlorethen
1,2-dichloroethene · (Z)-1,2-Dichloroethene · Dioform · Dichloroethylene · Dichloroethylenes · Ethene, 1,2-dichloro- · Residual Solvent Class 2 - 1,2-Dichloroethene · NCI-C56031
Identifikatoren & physikalische Daten
| CAS No. | 540-59-0 |
|---|---|
| Summenformel | C2H2Cl2 |
| Durchschnittliche Molmasse | 96,94 g/mol |
| Monoisotopische Masse | 95,95335542 g/mol |
| SMILES | ClC=CCl |
| InChIKey | KFUSEUYYWQURPO-UHFFFAOYSA-N |
| PubChem CID | 10900 |
| ChEMBL | CHEMBL1385560 |
| EC No. | 208-750-2 |
| DTXSID | DTXSID8024991 |
| Lokaler Name | 1,2-Dichlorethen |
Chemische & physikalische Eigenschaften
| XLogP | 1,9 |
|---|---|
| Polarare Oberfläche (TPSA) | 0 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 0 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 4 |
| Formalladung | 0 |
| Komplexität | 19,2 |
| Stoffklassen | Flammable agents - 3rd degree |
| Solvents | Solvents -> Chlorinated Aliphatics |
| SpringerMaterials Properties | Corrosion |
| LogP (Verteilungskoeffizient) | log Kow = 1.862 |
| Geruch | Ethereal, slightly acridPleasantSweet, slightly irritating chloroform-like odor... Slightly acrid, chloroform-like odor |
| Dichte | 1.27 at 77 °F (USCG, 1999) - Denser than waterwill sinkApproximately 1.28Relative density (water = 1): 1.28~1.28 No temp(77 °F): 1.271.265 g/mL at 25 °C(lit.) |
| Color/Form | Colorless liquid (usually a mixture of the cis- and trans-isomers) ...Mobile liquid |
| Löslichkeit | less than 1 mg/mL at 70 °F (NTP, 1992)In water, 3.50X10+3 mg/L at 25 °CInsoluble in waterSoluble in alcohol, ether, and most other organic solventsSoluble in most organic solventsSolubility in water: poorAcetonitrile (Slightly), Chloroform (Soluble) |
| Corrosivity | 1,2-Dichloroethylene will attack some forms of plastics, rubber, and coatings. |
| Flammpunkt | 39 °F (NTP, 1992)2 °C6 °C (43 °F) - closed cup36 °F (2 °C) - closed cup2 °C c.c.36-39 °F |
| Siedepunkt | 118 to 140 °F at 760 mmHg (NTP, 1992)55 °C118-140 °F55 °C @760 [mm Hg]48-60 °C(lit.) |
| Decomposition | Hazardous decomposition products formed under fire conditions - Carbon oxides, hydrogen chloride gas.... Gradually decomposed by light, air, and moisture, forming /hydrogen chloride/.Gradual decomposition results in hydrochloric acid formation in the presence of ultraviolet light or upon contact with hot metal or other hot surfaces.When heated to decomposition it emits highly toxic fumes of /chloride/. |
| Schmelzpunkt | −57 °C(lit.) |
| Dampfdruck | 5.32 psi ( 20 °C) |
| Brechungsindex | n20/D 1.447(lit.) |
| Aggregatzustand | Colorless liquid |
| Geruch | Ethereal, slightly acridpleasant, chloroform-like. |
| Merck | 13,94 |
| Henry-Konstante | 1.2×10-2 mol/(m3Pa) at 25℃, Keshavarz et al. (2022) |
| Dielektrizitätskonstante | 4.6(17℃) |
| Stabilität | Light Sensitive, Volatile |
| InChI | InChI=1S/C2H2Cl2/c3-1-2-4/h1-2H |
| InChIKey | KFUSEUYYWQURPO-UHFFFAOYSA-N |
| SMILES | C(Cl)=CCl |
| LogP (Verteilungskoeffizient) | 2.000 |
| EPA chemische Informationen | 1,2-Dichloroethylene (540-59-0) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH225: Highly Flammable liquid and vapor [Danger Flammable liquids]P210, P233, P240, P241, P242, P243, P261, P271, P273, P280, P303+P361+P353, P304+P340, P317, P370+P378, P403+P235, and P501 (click each P-code to see the statement)H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids] |
|---|---|
| Regulatorische Informationen | Chemical: Ethene, 1,2-dichloro-Ethene, 1,2-dichloro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethene, 1,2-dichloro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)1,2-Dichloroethylene: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| DOT-Kennzeichnung | Flammable Liquid |
| Brandgefahren | Special Hazards of Combustion Products: Phosgene and hydrogen chloride fumes may form in fires.· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire. Vapour/air mixtures are explosive. |
| Brandpotenzial | Flammable liquid.Highly flammable ... . |
| Gesundheitsgefahren | Inhalation causes nausea, vomiting, weakness, tremor, epigastric cramps, central nervous depression. Contact with liquid causes irritation of eyes and (on prolonged contact) skin. Ingestion causes slight depression to deep narcosis. (USCG, 1999)· May cause toxic effects if inhaled or absorbed through skin. |
| Gefahrenübersicht | 1, 2-Dichloroethene, also called 1, 2-dichloroethylene, is a highly flammable, colorless liquid with a sharp, harsh odor. It is used to produce solvents and in chemical mixtures. You can smell very small amounts of 1, 2-dichloroethene in air (about 17 parts of 1, 2-dichloroethene per million parts of air [17 ppm]). There are two forms of 1, 2-dichloroetheneone is called cis-1, 2-dichloroethene and the other is called trans-1,2-di-chloroethene. Sometimes both forms are present as a mixture.Liver injury observed in acute animal toxicology studies[ACGIH] A skin, eye, and respiratory tract irritantInhalation of high concentrations may cause CNS effects[ICSC]1,2-Dichloroethylene (UN1150) has warning of explosive polymerization[ERG 2016] See trans-1,2-Dichloroethylene and cis-1,2-Dichloroethylene. |
| DOT-Nummer und Handbuch | 1150 130P |
| FDA-Anforderungen | 1,2-Dichloroethylene (mixed isomers) is an indirect food additive for use only as a component of adhesives. |
| Reaktive Gruppe | Halogenated Organic Compounds |
| EG-Einstufung | Symbol: F, XnR: 11-20-52/53S: (2)-7-16-29-61Note: C |
| UN-Einstufung | UN Hazard Class: 3UN Pack Group: II |
| Special Reports | USEPAAmbient Water Quality Criteria Doc: Dichloroethylenes (1980) EPA 440/5-80-041Ahrenholz SHNIOSH, US Dept Health No. HETA-83-375-1521 (1984). Area and breathing zone samples were analyzed for carbon disulfide, carbon monoxide, carbon tetrachloride, chloroform, 1,2-dichloroethylene, ethylene dibromide, ethylene dichloride, methyl-bromide, and grain dust at the US Dept of Agriculture Federal Grain Inspection Service field office, Portland, Oregon in November, 1983 and April, 1984.U.S. Dept Health & Human Services/Agency for Toxic Substances & Disease RegistryToxicological Profile for 1,2-Dichloroethene (CAS#: 540-59-0 (mixture)156-59-2 (cis)156-60-5 (trans)) (August 1996)[Available from, as of May 1, 2018: http://www.atsdr.cdc.gov/toxprofiles/index.asp] |
| Brandbekämpfung | Fire Extinguishing Agents Not to Be Used: Water may be ineffective.Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
| Erste-Hilfe-Maßnahmen | Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse skin with plenty of water or shower.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention . |
| Freisetungsmaßnahmen | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.General First Aid:(General first aid procedures) |
| Sichere Lagerung | Fireproof. Well closed. See Chemical Dangers. |
| Firefighting Hazards | Vapors are heavier than air and may travel to a source of ignition and flash back. ... Closed containers may rupture violently when heated. |
| Expositionsschutz und Persönliche Schutzausrüstung | · Wear positive pressure self-contained breathing apparatus (SCBA).200.0 [ppm] |
| Brandbekämpfungsverfahren | Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.Use water spray to cool unopened containers.Use dry chemical, foam, carbon dioxide, or water spray. Use flooding quantities of water to blanket the fire. Water may be ineffective. Use water spray to keep fire-exposed containers cool. Fight fire from protected location or maximum possible distance.If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. |
| Lagerbedingungen | Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Air, light, and moisture sensitive.Store in a flammable liquid storage area or approved cabinet away from ignition sources and corrosive and reactive materials. Prior to working with 1,2-DCE you should be trained on its proper handling and storage. Before entering a confined space where this chemical may be present, check to make sure that an explosive concentration does not exist. 1,2-Dichloroethylene must be stored to avoid contact with strong oxidizers (such as chlorine, bromine, and fluorine) since violent reactions occur. Store in tightly closed containers in a cool, well-ventilated area away from heat. Sources of ignition, such as smoking and open flames, are prohibited where 1,2-dichloroethylene is used, handled, or stored. Metal containers involving the transfer of 5 gallons or more of 1,2-dichloroethylene should be grounded and bonded. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only nonsparking tools and equipment, especially when opening and closing containers of 1,2-dichloroethylene. Wherever 1,2-dichloroethylene is used, handled, manufactured, or stored, use explosion-proof electrical equipment and fittings.Store in a cool, dry, well-ventilated location. Separate from air, light, heat, strong oxidizing materials. |
| Reinigungsverfahren | ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.Spill or leak procedures: Eliminate all ignition sources. Stop or control the leak, if this can be done without undue risk. Use appropriate foam to blanket release and suppress vapors. Absorb in noncombustible material for proper disposal.Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Establish forced ventilation to keep levels below explosive limit. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or a similar material and deposit in sealed containers. Keep this chemical out of a confined space, such as a sewer, because of the possibility of an explosion ... . It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. ...Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Remove all ignition sources. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations. |
| Freisetung ohne Brand | Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)polymerization hazard]: |
| Entsorgungsverfahren | Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U079, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this materialContaminated packaging: Dispose of as unused product.SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. Also, a potential candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids. Also a potential candidate for liquid injection incineration at a temperature range of 650 to 1,600 °C and a residence time of 0.1 to 2 seconds. /Trans-1,2-Dichloroethylene/For more Disposal Methods (Complete) data for 1,2-Dichloroethylene (7 total), please visit the HSDB record page. |
| Toxikologische Informationen | CDC-ATSDR Toxicological Profile |
| Treatment | Following inhalation exposure, move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids. In case of seizures, administer a benzodiazepine IV. Irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes in case of eye exposure. Following dermal exposure, remove contaminated clothing and wash exposed area thoroughly with soap and water. Treat dermal irritation or burns with standard topical therapy. Patients developing dermal hypersensitivity reactions may require treatment with systemic or topical corticosteroids or antihistamines. (T36) |
| Wechselwirkungen | Inhalation studies were conducted to determine the potential subchronic toxicity of a mixture of trans-1,2-dichloroethylene (70%), cis-1,2-dichloroethylene (5%), and perfluorobutylethylene (25%). Groups of rats were exposed to 0, 400, 2000, or 8000 ppm concentrations of the mixture vapor 6 hr/day, 5 days/wk, for a total of 20 exposures. Subgroups of rats were further observed during a 1-month recovery period. Functional observational battery (FOB) and motor activity (MA) behavioral tests were conducted prior to initiation of the exposures, during exposure wk 4, and after a 1-month post-exposure recovery period. Clinical pathology evaluations were conducted at the end of the exposure period and after a 1-month recovery period. At the end of the 4-wk exposure period, tissues from rats were collected, histologically processed, and evaluated by light microscopy. Test substance-related, biologically significant decreased body weights and body weight gains occurred in male and female rats exposed to 8000 ppm. In addition, test substance-related, statistically significant decreases in food consumption and/or food efficiency were observed in male rats exposed to 8000 ppm. During exposures to 8000 ppm, some rats exhibited tremors and ataxia. Usually tremors and ataxia were observed within 1 hr after initiation of the daily exposure period and were observed during each exposure day. Tremors were also observed during 1 exposure day in the 2000 ppm animals. In addition to the tremors and ataxia, rats exposed to 2000 ppm or 8000 ppm had a diminished and/or no alerting response to a sharp, sound stimulus during each of the daily exposure periods. These effects were transient since no clinical observations of compromised neurological function were detected when the rats were evaluated upon return to the animal room following exposure. Daily reoccurrence of this apparently acute effect in the 8000 ppm group did not produce enduring neurological changes since there were no test substance-related effects on FOB parameters or on MA conducted the day following the last exposure or during the recovery period. In addition, there were no toxicologically significant changes in hematology, clinical chemistry, or urinalysis parameters in either males or females for any exposure concentrationand there were no test substance-related gross or microscopic morphological changes in males or females administered any exposure concentration. Under the conditions of the study, the no-observed-effect level (NOEL) was 400 ppm in males and females based on clinical signs of toxicity during exposure to 2000 or 8000 ppm. /Mixture of trans-1,2-dichloroethylene (70%), cis-1,2-dichloroethylene (5%), and perfluorobutylethylene (25%)/ |
| Zielorgane | Dermal (Skin), Immunological (Immune System), Ocular (Eyes)Eyes, respiratory system, central nervous system |
| Gesundheitliche Auswirkungen | Breathing trans-1,2-DCE can cause sever liver and kidney damages, pulmonary capillary hyperemia, as well as alveolar septal distentiondepression of the central nervous sustem can occurmoderate iritis and conjunctivitis can follow eye exposuredermatitis and irritation of mucous membranes can follow dermal exposure. Symptoms associated with lethal oral doses included decreased activity, ataxia, suppressed or total loss of righting reflex, and depressed respiration. (L585) |
| Ökotoxizitätswerte | LC50Species: Lepomis macrochirus (Bluegill) Young of Year, weight 0.32-1.2 gConditions: freshwater, static, 21-23 °C, pH 6.5-7.9, hardness 32-48 mg/L CaCO3, alkalinity 28-34 mg/L CaCO3, conductivity 93-190 umhos/cm, dissolved oxygen 0.3-9.7 mg/LConcentration: 165000 uM for 24 hr /> or = 80% purity/Concentration: 140000 ug/L for 96 hr (95% confidence interval: 120000-160000 ug/L) /> or = 80% purity/Species: Eisenia fetida (Earthworm) adult, weight 300-500 mgdermal 286 ug/sq cm for 48 hr (95% confidence interval: 264-308 ug/sq cm) /> or =98% purity/ |
| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 40(SRC), determined from a structure estimation method(2), indicates that 1,2-dichloroethylene is expected to have very high mobility in soil(SRC). Volatilization of 1,2-dichloroethylene from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 4.08X10-3 atm-cu m/mole(3). 1,2-Dichloroethylene is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 201 mm Hg at 25 °C(4). cis- and trans-1,2-Dichloroethylene, present at 2.62 and 2.32 mg/L, respectively, reached 0% of its Theoretical BOD in 4 weeks using an activated sludge inoculum in the Japanese MITI test(5), suggesting that biodegradation is not an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 40(SRC), determined from a structure estimation method(2), indicates that 1,2-dichloroethylene is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 4.08X10-3 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 3 hours and 4 days, respectively(SRC). 1,2-Dichloroethylene is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). According to a classification scheme(5), an estimated BCF of 8(SRC), from its log Kow of 1.86(6) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low. 1,2-Dichloroethylene has a first-order biodegradation half-life of 31 and 478 days in stream bed sediment under aerobic and anaerobic conditions, respectively(7), suggesting that biodegradation may proceed under certain environmental conditions(SRC). No biodegradation of trans-1,2-dichloroethylene occurred in a river die-away test(8). Biodegradation of 1,2-dichloroethylene was 50% and 73% of the cis- and trans- isomer, respectively, studied in microcosms prepared from uncontaminated organic sediment from the Everglades incubated anaerobically for 6 months(9).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,2-dichloroethylene, which has a vapor pressure of 201 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,2-dichloroethylene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 8 days(SRC), calculated from its isomer average rate constant of 2.1X10-12 cu cm/molecule-sec at 25 °C(3). Vapor-phase 1,2-dichloroethylene is also degraded in the atmosphere by reaction with ozone(SRC)the half-life for this reaction in air is estimated to be 480 days(SRC), calculated from its isomer average rate constant of 2.7X10-20 cu cm/molecule-sec at 25 °C(4). 1,2-Dichloroethylene does not contain chromophores that absorb at wavelengths >290 nm(5) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). |
| Unerwünschte Wirkungen | Neurotoxin - Acute solvent syndrome |
| Expositionspfade | The substance can be absorbed into the body by inhalation of its vapour and by ingestion.inhalation, ingestion, skin and/or eye contactInhalation (L585)oral (L585)dermal (L585)eye contact (L585) |
| Toxizitätsübersicht | IDENTIFICATION AND USE: 1,2-Dichloroethylene (DCE) is a colorless mobile liquid. It is used as a refrigerant, in the manufacture of pharmaceuticals and artificial pearls, and in the extraction of oils and fats from fish and meat. It is also a solvent for fats, phenol, camphor, and an intermediate in synthesis of chlorinated solvents and compounds. HUMAN STUDIES: Clinical effects caused by acute exposure to DCE include central nervous system and respiratory depression, eye and upper respiratory irritation, nausea, vomiting, weakness, tremors, and epigastric cramps, all of which may resolve rapidly after the exposure ceases. The investigation of workers exposed to DCE indicated that prematurities among exposed female workers and wives of exposed male workers were higher than that of control groups. The DNA breakage capacity and the cytotoxicity of DCE was assessed in the alkaline single cell gel electrophoresis test (comet assay) with and without metabolic activation in isolated human lymphocytes. DCE induced DNA breakage, in the presence or absence of the metabolic activation system. ANIMAL STUDIES: Some but not all dogs experienced CNS depression by inhaling the DCE vapor and have developed delicate superficial corneal turbidity. A subchronic inhalation study was conducted in which rats, rabbits, guinea pigs, and beagle dogs were exposed to 0, 500, or 1,000 ppm (0, 1,980, or 3,960 mg/cu m) DCE mixture (58% cis-, 42% trans- isomer), 7 hours/day for 6 months. No significant toxicity was found. Behavioral changes have been observed in mice exposed for 4 hr to DCE. The reported changes consisted of a dose-related decrease in the duration of immobility in the "behavioral despair" swimming test. A 45% decrease in the total duration of immobility occurred at a concentration of 1,720 ppm. Gonadotoxicity and embryotoxicity were found in rodents exposed to concentration of DCE at 24.8 mg/cu m. DCE could reach the fetus through the placenta. Cis,trans-DCE was found to be negative when tested for mutagenicity using the Salmonella/microsome preincubation assay in as many as 5 Salmonella typhimurium strains (TA1535, TA1537, TA97, TA98, and TA100) in the presence and absence of metabolic activation.Trans-1,2-dichloroethene is a volatile, lipophilic molecule that easily moves through the respiratory and gastrointestinal systems. It has a high affinity for lipids and blood, but little accumulation in tissues. 1,2-Dichloroethene isomers inhibit liver enzymes involved in metabolism and may increase the “toxic” response to other chemicals. Reactive metabolites of trans-1,2-dichloroethene modify the heme moiety of hepatic microsomal cytochrome P-450, resulting in a loss of both cytochrome P-450 and heme. Trans-1,2-dichloroethene can also mixed-function oxidase activities. Metabolism of trans-1,2-dichloroethene can lead to dose-related decrease in the levels of serum glutamicoxaloacetic transaminase (SGOT) and serum glutamic-pyruvic transaminase (SGPT). (L585) |
| Signs and Symptoms | Cough. Sore throat. Dizziness. Nausea. Drowsiness. Weakness. Unconsciousness. Vomiting.Dry skin.Redness. Pain.Abdominal pain. Further see Inhalation.irritation eyes, respiratory systemcentral nervous system depressionSymptoms of trans-1,2-DCE exposure include nausea, dowiness, and tiredness. Mild or moderate erythema may follow dermal exposure, and skin or eye irritation can follow dermal/eye contact. (L585) |
| Ongoing Test Status | EPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPAICSS Dashboard ApplicationAvailable from, as of August 9, 2018: http://actor.epa.gov/dashboard/]The following link will take the user to the National Toxicology Program (NTP) Test Status of Agents Search page, which tabulates the results and current status of tests such as "Short-Term Toxicity Studies", "Long-term Carcinogenicity Studies", "Developmental Studies", "Genetic Toxicology Studies", etc., performed with this chemical. Testing status for 1,2-dichloroethylene is available.[Available from, as of August 8, 2018: https://ntpsearch.niehs.nih.gov/?e=True&ContentType=Testing+Status] |
| RCRA-Anforderungen | U079As stipulated in 40 CFR 261.33, when trans-1,2-dichloroethylene, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5). /Trans-1,2-Dichloroethylene/ |
| TSCA-Anforderungen | Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329. Effective date: 3/11/94Reporting date: 5/10/94.Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. 1,2-Dichloroethylene is included on this list. Effective date: 3/11/94Sunset date: 6/30/98. |
| CERCLA-Meldepflichtmengen | Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV.D.3.b). /trans-1,2-Dichloroethylene/ |
| Clean Water Act Anforderungen | Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. |
| State Drinking Water Standards | (FL) FLORIDA 70 ug/L |
| Landesrichtlinien für Trinkwasser | (AZ) ARIZONA 70 ug/L |
| Berufliche Expositionsstufe (OEB) | A |
| Arbeitsplatzgrenzwert (OEL) | TWA: 200 ppm (790 mg/m3) |
| Wassergefährdungsklasse (WGK) | 2 |
| Sofort lebensgefährliche Konzentration | 1,000 ppm |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN 1150 |
| RTECS-Nr. | KV9360000 |
| R-Sätze (R) | 11-20-52/53 |
| Toxizität | LD50 i.p. in mice: ~2150 mg/kg (Gradiski) |
| Gefahrensymbole | F,Xn |
| Sicherheitshinweise (S) | 7-16-29-61 |
| Gefahrenklasse | 3Acute Tox. 4 InhalationAquatic Chronic 3Flam. Liq. 2 |
| Verpackungsgruppe | II |
| Lagerklasse | 3 - Flammable liquids |
| Gefahrstoffdaten | 540-59-0(Hazardous Substances Data) |
Anwendungen & Verwendung
Beschreibung
Acetylene dichloride is a colourless liquid (usually a mixture of the cis and trans isomers) with a slightly acrid, chloroform-like odour. Acetylene dichloride is a chemical used mainly in the production of perfumes, dyes, and thermoplastics. The type and severity of symptoms varies depending on the amount of chemical involved and the nature of the exposure. It is incompatible with strong oxidisers, strong alkalis, potassium hydroxide, and copper. Acetylene dichloride is highly flammable and in a fire gives off irritating or toxic fumes/gases. (Acetylene dichloride usually contains inhibitors to prevent polymerisation.)
Verwenden
1,2-Dichloroethylene is used as a solvent for organic materials and as an intermediate in the synthesis of other chlorinated compounds; it may be produced by the chlorination of acetylene but is often produced as a by-product in the manufacture of other chlorinated compounds.