Decamethoniumbromid
1,10-Decanediaminium, N,N,N,N',N',N'-hexamethyl-, dibromide
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Grundinformationen
- CAS
541-22-0- Standard-SMILES
C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C.[Br-].[Br-]- InChIKey
HLXQFVXURMXRPU-UHFFFAOYSA-L- Summenformel
- C16H38Br2N2
- Durchschnittliche Molmasse
- 418,302 g/mol
- Monoisotopische Masse
- 416,14017342
Namen und Bezeichner
- Bevorzugter Name
- 1,10-Decanediaminium, N,N,N,N',N',N'-hexamethyl-, dibromide
- IUPAC
- N~1~,N~1~,N~1~,N~10~,N~10~,N~10~-Hexamethyldecane-1,10-bis(aminium) dibromide
- Lokaler Name
- Decamethoniumbromid
- Englischer Name
- DECAMETHONIUM BROMIDE
- Summenformel
- C16H38Br2N2
- Molmasse
- 418.29
Namen und Synonyme
decacuransyncurinedekamethoniumbromidDECAMETHONIUM BROMIDEdecamethoniumdibromideDecamethonium Bromide >Decamethonium bromide ,98%Decamethonium Bromide, ≥ 98.0%DECAMETHONIUM BROMIDE USP/EP/BPDecamethonium bromide, 10 mM in DMSO
Datenbank-Bezeichner
- CAS
541-22-0- PubChem CID
- 10921
- DTXSID
DTXSID2022886- ChEMBL
CHEMBL1134- UNII
- 55C6RK944K
- EC Number
- 208-772-2
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 263 · 263-267 °C(lit.)
- storage temp.
- Inert atmosphere,Room Temperature
- Löslichkeit
- 2 mg/ml; · DMF: 2 mg/ml; DMSO: 16 mg/ml; Ethanol: 33 mg/ml; PBS (pH 7.2): 5 mg/ml
- Aggregatzustand
- crystalline
- Farbe
- off-white
- Wasserlöslichkeit
- almost transparency
- Merck
- 14 · 14,2847
- BRN
- 3728288 · 3728288
- Stabilität
- Stable. Incompatible with strong oxidizing agents.
- InChI
- 1S/C16H38N2.2BrH/c1-17(2,3)15-13-11-9-7-8-10-12-14-16-18(4,5)6;;/h7-16H2,1-6H3;2*1H/q+2;;/p-2
- InChIKey
- HLXQFVXURMXRPU-UHFFFAOYSA-L
- SMILES
- [Br-].[Br-].C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C
- CAS Datenbank
- 541 · 541-22-0(CAS DataBase Reference)
- EPA chemische Informationen
- Decamethonium dibromide (541-22-0)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- F
- 3-10
- wgk
- 3
- tsca
- TSCA listed
- ridadr
- UN 2811 6.1/PG 3
- hs_code
- 2923.90.0100
- RTECS-Nr.
- BP5950000
- risk_code
- 25-36/37/38
- Toxizität
- LD50 oral in mouse: 190mg/kg
- hazard_code
- T
- safety_code
- 26-45
- hazard_class
- 6.1(b)
- packing_group
- III
- Speicherklasse
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- Hazard Classifications
- Acute Tox. 3 OralEye Irrit. 2Skin Irrit. 2STOT SE 3
Chemie und Industrie
Anwendungen
BeschreibungDecamethonium is a depolarizing neuromuscular blocking agent. It is a partial agonist of muscle-type nicotinic acetylcholine receptors (nAChRs). Decamethonium activates α1β1-containing adult mouse muscle-type nAChRs expressed in X. laevis oocytes with an EC50 value of 40 μM using voltage clamp electrophysiology. It is also a nondepolarizing antagonist of neuronal-type nAChRs, inhibiting mouse α7-, α3β2-, α3β4-, and α4β2-containing receptors with IC50 values of 7.4, 405, 28, and 59 μM, respectively. Decamethonoium is a competitive antagonist of α4β2-containing nAChRs expressed in SH-EP1 cells (IC50 = 52 μM for the human receptor). It also inhibits electric eel acetylcholinesterase (AChE) and blocks electrically-evoked tibialis muscle twitches in anesthetized cats with ED95 values of 35 and 70 μg/kg for cats under chloralose and ether anesthesia, respectively. Formulations containing decamethonium have been used to induce paralysis during anesthesia.
Verwendenantipsychotic
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