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2-Hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]propansulfonsure
APSO · TAPSO · TAPSO Buffer · TAPSO FREE ACID · TAPSO ULTRAPURE · TAPSO,BIOLOGICALBUFFER · TAPSO, for biochemistry · Tapso≥ 99.9% (titration)
![Molekülstruktur von 2-Hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]propansulfonsure](/img/chemical/109334.png)
Identifikatoren & physikalische Daten
| CAS No. | 68399-81-5 |
|---|---|
| Summenformel | C7H17NO7S |
| Durchschnittliche Molmasse | 259,28 g/mol |
| Monoisotopische Masse | 259,07257288 g/mol |
| SMILES | O=S(=O)(O)CC(O)CNC(CO)(CO)CO |
| InChIKey | RZQXOGQSPBYUKH-UHFFFAOYSA-N |
| PubChem CID | 109334 |
| EC No. | 269-993-8 |
| DTXSID | DTXSID80887356 |
| Lokaler Name | 2-Hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]propansulfonsure |
Chemische & physikalische Eigenschaften
| XLogP | -6,4 |
|---|---|
| Polarare Oberfläche (TPSA) | 156 |
| H-Brücken-Donoren | 6 |
| H-Brücken-Akzeptoren | 8 |
| Frei drehbare Bindungen | 8 |
| Schwere Atome | 16 |
| Formalladung | 0 |
| Komplexität | 273 |
| Stoffklassen | Other Uses -> Biological Buffers |
| Physical Description | Colorless solid[Merck Index] White crystalline solid[Sigma-Aldrich MSDS] |
| Schmelzpunkt | 224-229 °C (dec.) |
| Dichte | 1.07607 g/cm3(Temp: 25.00 °C) |
| Lagerbedingungen | Keep in dark place,Inert atmosphere,Room temperature |
| Löslichkeit | H2O: 1 M at 20 °C, clear, colorlesssoluble |
| Aggregatzustand | Powder |
| Farbe | Off-white to yellow |
| pKa (Säurekonstante) | 7.6(at 25℃) |
| pH | 7.0-8.2 |
| Merck | 13,9148 |
| BRN | 2113949 |
| Hauptanwendungen | diagnostic assay manufacturing |
| InChI | InChI=1S/C7H17NO7S/c9-3-7(4-10,5-11)8-1-6(12)2-16(13,14)15/h6,8-12H,1-5H2,(H,13,14,15) |
| InChIKey | RZQXOGQSPBYUKH-UHFFFAOYSA-N |
| SMILES | C(S(O)(=O)=O)C(O)CNC(CO)(CO)CO |
| CAS Datenbank | 68399-81-5(CAS DataBase Reference) |
| EPA chemische Informationen | 1-Propanesulfonic acid, 2-hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]- (68399-81-5) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 4.5% (2 of 44) of reports.WarningH315 (95.5%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 44 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Gefahrenübersicht | A skin and strong eye irritant[Sigma-Aldrich MSDS] See 3-(Tris(hydroxymethyl)methylamino)-1-propanesulfonic acid. |
| Hazard Classes and Categories | Skin Irrit. 2 (95.5%) |
| Wassergefährdungsklasse (WGK) | 3 |
| TSCA-Inventar-Status | TSCA listed |
| Zollcode | 29221990 |
| R-Sätze (R) | 36/37/38 |
| Gefahrensymbole | Xi |
| Sicherheitshinweise (S) | 26-36 |
| Gefahrenklasse | IRRITANTEye Irrit. 2Skin Irrit. 2STOT SE 3 |
| Lagerklasse | 11 - Combustible Solids |
Anwendungen & Verwendung
Verwenden
TAPSO is a zwitterionic biological buffer often used as a buffering agent in biological and biochemical research. It has a pKa value of 7.635 (I=0, 25°C) and can be used to make buffer solutions in the pH range 7.0-8.2. As an Good'buffer, TAPSO contains Tris groups and exhibits quite reactive activity with zwitterionic glycine peptides[1]. TAPSO can serve as good stabilizers for the globular protein BSA, in the aqueous solutions[2].The solubilities of TAPSO increase with increasing concentration of the salts (salting-in effect)[3].