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Eosin
Eosin · Acid Red 87 · Esoin Y · Eosin Y Na · AMI-5 · RED 22 · RED 21 LAKE · EOSIN Y DISODIUM
Identifikatoren & physikalische Daten
| CAS No. | 17372-87-1 |
|---|---|
| Summenformel | C20H6Br4Na2O5 |
| Durchschnittliche Molmasse | 691,9 g/mol |
| SMILES | O=C([O-])c1ccccc1-c1c2cc(Br)c(=O)c(Br)c-2oc2c(Br)c([O-])c(Br)cc12.[Na+].[Na+] |
| InChIKey | SEACYXSIPDVVMV-UHFFFAOYSA-L |
| PubChem CID | 11048 |
| ChEMBL | CHEMBL408917 |
| ChEBI | CHEBI:52053 |
| EC No. | 241-409-6 |
| DTXSID | DTXSID901015574 |
| Lokaler Name | Eosin |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 89,5 |
|---|---|
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 5 |
| Frei drehbare Bindungen | 1 |
| Schwere Atome | 31 |
| Formalladung | 0 |
| Komplexität | 796 |
| Stoffklassen | Dyes -> Di- and Triaryl Dyes |
| Kosmetika | Hair dyeingCosmetic colorant |
| Lebensmittelzusatzstoffe | Drugs, Cosmetics -> FDA Regulatory Status of Color Additives |
| Löslichkeit | greater than or equal to 100 mg/mL at 70 °F (NTP, 1992)H2O: 0.1 g/mL, dark redfreely soluble |
| Schmelzpunkt | 572 °F (decomposes) (NTP, 1992)>300°C |
| Physical Description | Eosin is a red crystalline powder. (NTP, 1992)Red with a bluish tinge or brownish-red solid[Merck Index] |
| Dichte | 1.02 g/mL at 20 °C |
| Dampfdruck | 0Pa at 25℃ |
| Flammpunkt | 11 °C |
| Lagerbedingungen | Store at RT. |
| Aggregatzustand | Solid |
| pKa (Säurekonstante) | 2.9, 4.5(at 25℃) |
| Farbe | Reddish |
| pH | 9.2 (10g/l, H2O, 20℃) |
| Merck | 14,3603 |
| BRN | 3586809 |
| Stabilität | Stable. Incompatible with strong oxidizing agents. |
| Hauptanwendungen | Photovoltaic devices, color filter, nanoscale host material, detection of latent fingerprints, inks, detergents, hair dyes, cosmetics, implantable drug delivery devices, stents, diagnosis of breast lesions, labeling nucleic acids, detecting proteins, stress biomarkers, phosphoprotein, breast cancer metastases, antimicrobial agent, treatment of burns, endodontic, diabetes, obesity, cancer, radiochemotherapy, DNA sequencing, gene expression profiling, wound healing promoters |
| Kosmetik-Inhaltsstoffe Funktionen | HAIR DYEINGCOLORANT |
| InChI | 1S/C20H8Br4O5.2Na/c21-11-5-9-13(7-3-1-2-4-8(7)20(27)28)10-6-12(22)17(26)15(24)19(10)29-18(9)14(23)16(11)25/h1-6,25H,(H,27,28)/q2*+1/p-2 |
| InChIKey | SEACYXSIPDVVMV-UHFFFAOYSA-L |
| SMILES | [Na+].[Na+].Brc1c2[o][c]3[c](c(c2cc([c]1=O)Br)c4c(cccc4)C(=O)[O-])=CC(=C(C=3Br)[O-])Br |
| LogP (Verteilungskoeffizient) | -1.33 |
| CAS Datenbank | 17372-87-1(CAS DataBase Reference) |
| EPA chemische Informationen | Eosin Yellowish (YS) (17372-87-1) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 7% (47 of 671) of reports.WarningH319 (87%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)Aggregated GHS information provided per 671 reports by companies from 12 notifications to the ECHA C&L Inventory.This chemical does not meet GHS hazard criteria for 50% (1 of 2) of reports. |
|---|---|
| Regulatorische Informationen | Chemical: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-, disodium saltREACH registered substance: Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate (EC: 241-409-6)Eosin disodium salt: Does not have an individual approval but may be used under an appropriate group standardC.I. Acid red 87: Does not have an individual approval but may be used under an appropriate group standard |
| Brandgefahren | Flash point data for this chemical are not availablehowever, it is probably combustible. (NTP, 1992) |
| Gesundheitsgefahren | SYMPTOMS: Symptoms of exposure to this chemical include cheilitis, facial dermatitis and stomatitis. |
| Gefahrenübersicht | May cause facial dermatitis[NTP] A moderate eye irritant[Sigma-Aldrich MSDS] |
| Reaktive Gruppe | Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters |
| Air and Water Reactions | Water soluble. |
| Hazard Classes and Categories | Eye Irrit. 2 (87%) |
| Brandbekämpfung | Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992) |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
Anwendungen & Verwendung
Verwenden
Eosin is most often used as a counterstain to haematoxylin in H&E (haematoxylin and eosin) staining. H&E staining is one of the most commonly used techniques in histology.
Herstellung & Synthese
synthetische
countries called red. Fluorescent element (C.I. Acid Yellow 73, C.I. 45350) in water or ethanol solution bromine into four bromine derivatives, and then into sodium salt.