Cyclanilide

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Tolerances are established for residues of the plant growth regulator, cyclanilide, (1-(2,4-dichlorophenylaminocarbonyl)-cyclopropane carboxylic acid) determined as 2,4-dichloroaniline (calculated as cyclanilide) in or on the following food commodities and processed feed: cattle, fat: 0.10 ppm; cattle, meat: 0.02 ppm; cattle, mbyp (except kidney): 0.2 ppm; cattle, kidney: 2.0 ppm; cottonseed: 0.60 ppm; cotton gin byproducts: 25.0 ppm; goats, fat: 0.10 ppm; goats, meat: 0.02 ppm; goats, mbyp (except kidney): 0.20 ppm; goats, kidney: 2.0 ppm; horses, fat: 0.10 ppm; horses, meat: 0.02 ppm; horses, mbyp (except kidney): 0.2 ppm; horses, kidney: 2.0 ppm; hogs, fat: 0.10 ppm; hogs, meat: 0.02 ppm; hogs, mbyp (except kidney): 0.2 ppm; hogs, kidney: 2.0 ppm; milk: 0.04 ppm; sheep, fat: 0.10 ppm; sheep, meat: 0.02 ppm; sheep, mbyp (except kidney): 0.2 ppm; sheep, kidney: 2.0 ppm.

LD50 Bobwhite quail 240 mg ai/kg bw (14 day) /Conditions of bioassay not specified./

LC50 Bobwhite quail 2580 ppm (8 day) /Conditions of bioassay not specified./

LC50 Mallard duck 1740 ppm (8 day) /Conditions of bioassay not specified./

LC50 Bluegill sunfish >16 mg ai/L (96 hr) /Conditions of bioassay not specified./

For more Ecotoxicity Values (Complete) data for CYCLANILIDE (9 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), a Koc range of 194 to 565(3) indicates that cyclanilide is expected to have moderate mobility in soil(SRC). Volatilization of cyclanilide from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 7.31X10-10 atm-cu m/mole(2). Cyclanilide is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 9.1X10-9 mm Hg(SRC), determined from a fragment constant method(3). Biodegradation may be an important environmental fate process in soil as it has been reported to be readily biodegradable to 2,4-dichloroaniline with a half-life of 95 days for the parent compound(4).

AQUATIC FATE: Based on a classification scheme(1), Koc values ranging from 194 to 565(6) indicate that cyclanilide is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 7.31X10-10 atm-cu m/mole(2). According to a classification scheme(4), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(5), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Cyclanilide is relatively stable to hydrolysis(2). Biodegradation may be an important environmental fate process in water as it has been reported to be readily biodegradable in soil at a half-life of 95 days(6).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), cyclanilide, which has an estimated vapor pressure of 9.1X10-9 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase cyclanilide may be removed from the air by wet and dry deposition(SRC). Cyclanilide is relatively stable to photolysis; the half-life in aqueous solutions under simulated sunlight is approximately 50 to 55 summer Florida days(3). Photodegradation is not a major degradation pathway on soil surfaces(3).

AEROBIC: Cyclanilide, applied at 0.25 ppm, was readily degraded with a half-life of 95 days to 2,4-dichloroaniline, which is further degraded in soil to carbon dioxide(1). Based on field observations, degradation rates are slower during dry and cool autumn and winter seasons but increase with the increased moisture and warmth of the spring and summer seasons(1).

ANAEROBIC: Cyclanilide was not degraded in a water-sediment system(1).

An estimated BCF of 3 was calculated for cyclanilide(SRC), using a log Kow of 3.25(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for cyclanilide is 7.31X10-10 atm-cu m/mole(1). This Henry's Law constant indicates that cyclanilide is expected to be essentially nonvolatile from water surfaces(2). Cyclanilide is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 9.1X10-9 mm Hg(SRC), determined from a fragment constant method(3).

Severe ocular reaction (rabbits). /Finish Harvest Aid for Cotton/

Primary skin irritation (rabbits): erythema, edema & necrosis with resolution by day 10. /Finish Harvest Aid for Cotton/

Particulate-phase cyclanilide may be removed from the air by wet and dry deposition(SRC). Cyclanilide is relatively stable to hydrolysis(1). The compound is stable to photolysis as shown by continued stability after 14 days of exposure to artificial sunlight at 23 °C(1).

New Active Ingredients ... includes pesticide active ingredients initially registered after November 1, 1984, that currently have active product registrations. By law, these newer pesticides are not subject to the reregistration program. They must, however, meet the new safety standard of the FQPA, and will be reviewed on a 15-year cycle under the registration review program. ... Active Ingredient Number: 026201; Type of Pesticide: fungicide; Use Site: non-food use (cotton); Year: 1997.

Tolerances are established for residues of the plant growth regulator, cyclanilide, (1-(2,4-dichlorophenylaminocarbonyl)-cyclopropane carboxylic acid) determined as 2,4-dichloroaniline (calculated as cyclanilide) in or on the following food commodities and processed feed: cattle, fat; cattle, meat; cattle, mbyp (except kidney); cattle, kidney; cottonseed; cotton gin byproducts; goats, fat; goats, meat; goats, mbyp (except kidney); goats, kidney; horses, fat; horses, meat; horses, mbyp (except kidney); horses, kidney; hogs, fat; hogs, meat; hogs, mbyp (except kidney); hogs, kidney; milk; sheep, fat; sheep, meat; sheep, mbyp (except kidney); sheep, kidney.