Grundinformationen
- CAS
555-44-2- Standard-SMILES
CCCCCCCCCCCCCCCC(=O)OCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC- InChIKey
PVNIQBQSYATKKL-UHFFFAOYSA-N- Summenformel
- C51H98O6
- Durchschnittliche Molmasse
- 807,3 g/mol
- Monoisotopische Masse
- 806,73634084
Namen und Bezeichner
- Bevorzugter Name
- Tripalmitin
- IUPAC
- 2,3-di(hexadecanoyloxy)propyl hexadecanoate
- Lokaler Name
- Glycerintripalmitat
- Englischer Name
- Tripalmitin
- Summenformel
- C51H98O6
- Molmasse
- 807.32
Namen und Synonyme
TRIPALMITIN555-44-2Glycerol tripalmitateTripalmitoylglycerolGlyceryl tripalmitatePalmitic triglycerideTripalmitateDynasan 116Triglyceryl palmitateBarolubSpezialfett 116Speziafett 116
Weitere Namen anzeigen
PALMITINC16:0dynasan116Tripalmotintri-palmiti
Glyceryl trihexadecanoateBarolub LCDHexadecanoic acid, 1,2,3-propanetriyl esterPalmitic acid triglycerin esterDynosan 114Hexadecanoic acid, 1,1',1''-(1,2,3-propanetriyl) esterTripalmitoyl glyceroltripalmitina
Datenbank-Bezeichner
- CAS
555-44-2- PubChem CID
- 11147
- DTXSID
DTXSID8046169- ChEMBL
CHEMBL2002154- ChEBI
CHEBI:77393- UNII
- D133ZRF50U
- EC Number
- 209-098-1
- Nikkaji
- J6.469F
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 21,9
- Polarare Oberfläche (TPSA)
- 78,9 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 50
- Schwere Atome
- 57
- Formalladung
- 0
- Komplexität
- 798
Experimentelle und physikochemische Eigenschaften
Physical Description
Solid; [Merck Index] White powder; [Acros Organics MSDS]
Solid
Ionization Efficiency
Positive
2.27
2.7
Agilent XCT
Electrospray ionization
formic acid (5.3nM)
Collision Cross Section309.9 Ų [M+Na]+ [CCS Type: TIMS; Method: single field calibrated]；312.88 Ų [M+NH4]+ [CCS Type: TIMS; Method: single field calibrated]
Physikochemische Eigenschaften
- Schmelzpunkt
- 66 · 66-68 °C
- Siedepunkt
- 310 · bp 310-320°
- Dichte
- 0.8752 g/cm3 · 0.8752 g/cm3 (70 ºC)
- Brechungsindex
- 80 · nD80 1.43807
- storage temp.
- -20 °C · -20°C
- Löslichkeit
- Chloroform (Sparingly), Ethyl Acetate (Slightly), Hexanes (Very Slightly)
- Aggregatzustand
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 85.6% (107 of 125) of all reports.
H411 (14.4%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]
P273, P391, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 125 reports by companies from 2 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 107 of 125 reports by companies.；There is 1 notification provided by 18 of 125 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Gefahrenhinweise
Regulatory Information
Chemical: Hexadecanoic acid, 1,2,3-propanetriyl ester
Hexadecanoic acid, 1,2,3-propanetriyl ester: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Hexadecanoic acid, 1,2,3-propanetriyl ester: Environment tier I assessment；IMAP assessments - Hexadecanoic acid, 1,2,3-propanetriyl ester: Human health tier I assessment
Hazards SummaryIntraperitoneal lethal-dose (mouse) > 500 mg/kg; [RTECS] May cause irritation; [Acros Organics MSDS]
Hazard Classes and CategoriesAquatic Chronic 2 (14.4%)
Toxikologische Informationen
Chemie und Industrie
Pharmakologische Informationen
Cellular LocationsExtracellular；Membrane
Metabolite PathwaysD-glyceric acidura；De Novo Triacylglycerol Biosynthesis TG(16:0/16:0/16:0)；Familial lipoprotein lipase deficiency；Glycerol Kinase Deficiency；Glycerolipid Metabolism
Verwendung und Herstellung
Uses
CIR ingredient: Tripalmitin
Found in fats; [Merck Index]
Use ClassificationCosmetics -> Refatting; Viscosity controlling; Emollient; Solvent; Skin conditioning
General Manufacturing InformationHexadecanoic acid, 1,1',1''-(1,2,3-propanetriyl) ester: ACTIVE
Anwendungen
BeschreibungTripalmitin, also known as Palmitin or 1,2,3-Tripalmitoyl glycerol, comes from the fatty acid palmitic acid and is a triacylglycerol that contains palmitic acid at the sn-1, sn-2, and sn-3 positions and has been found in palm oil. It inhibits glucose-stimulated insulin secretion and reduces viability of INS1 cells in a concentration-dependent manner. Myocardial levels of 1,2,3-tripalmitoyl glycerol are elevated by greater than 5-fold in a rat model of diabetes induced by streptozotocin . 1,2,3-Tripalmitoyl glycerol has been used to form the lipid matrices of etoposide-incorporated nanoparticles. Formulations containing 1,2,3-tripalmitoyl glycerol have been used in cosmetic products as thickening and skin-conditioning agents.
VerwendenTripalmitin is a triglyceride derived from Palmitic Acid (P144500), a common fatty acid found in plants and animals. Tripalmitin is used in the preparation of solid lipid particles for oral delivery of drugs.
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