6α,9-Difluor-11β,17,21-trihydroxy-16α-methylpregna-1,4-dien-3,20-dion-21-acetat
Flumethasone Acetate
Grundinformationen
- CAS
2823-42-9- Standard-SMILES
CC(=O)OCC(=O)[C@@]1(O)[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C- InChIKey
ISSQQUKLQJHHOR-OSNGSNEUSA-N- Summenformel
- C24H30F2O6
- Durchschnittliche Molmasse
- 452,5 g/mol
- Monoisotopische Masse
- 452,201045
Namen und Bezeichner
- Bevorzugter Name
- Flumethasone Acetate
- IUPAC
- [2-[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
- Lokaler Name
- 6α,9-Difluor-11β,17,21-trihydroxy-16α-methylpregna-1,4-dien-3,20-dion-21-acetat
- Englischer Name
- Flumethasone-17-acetate
- Summenformel
- C24H30F2O6
- Molmasse
- 452.49
Namen und Synonyme
Flumethasone 21-acetateFlumethasone acetateFLUMETASONE ACETATEUNII-HB84ATQ00XHB84ATQ00XEINECS 220-581-6DTXSID50182481Fluosmin SuspensionRefChem:57255DTXCID60104972220-581-62823-42-9
Weitere Namen anzeigen
Flumethasone21-acetateflumethasone-17-acetateRegadenoson Impurity 326α-FluorodexaMethasone 21-AcetateFluticasone Propionate Impurity 23Flumethasone Pivalate EP Impurity BFlumetasone pivalate EP Impurity B(Flumethasone-17-acetate)6a,9-difluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 21-acetate1, 4-PREGNADIEN-6α, 9α-DIFLUORO-16α-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE 21-ACETATE
[2-[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate2-((6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetateFlumethasone 21-Acetate; 6a-Fluorodexamethasone 21-Acetate; 6a,9-Difluoro-11ss,17,21-trihydroxy-16a-methyl-pregna-1,4-diene-3,20-dione 21-Acetate;orb1705203SCHEMBL7155353ISSQQUKLQJHHOR-OSNGSNEUSA-N6a-Fluorodexamethasone 21-acetateGLXC-20127
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,5
- Polarare Oberfläche (TPSA)
- 101 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 8
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 32
- Formalladung
- 0
- Komplexität
- 945
Experimentelle und physikochemische Eigenschaften
Animal DrugsFDA approved animal drugs -> Active ingredient
Physikochemische Eigenschaften
- Schmelzpunkt
- 260 · 260-264 °C
- Siedepunkt
- 581 · 581.0±50.0 °C(Predicted)
- Dichte
- 1.33 · 1.33±0.1 g/cm3(Predicted)
- Löslichkeit
- DMSO (Slightly), Ethanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 11.93 · 11.93±0.70(Predicted)
- Farbe
- White to Off-White
- LogP
- 2.33 · 2.33
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory InformationREACH registered substance: 6α,9-difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate (EC: 220-581-6)
Hazard Classes and CategoriesAcute Tox. 4 (50%)
Sicherheitsdaten
- Alarmwort
- Warnung
- Gefahrenhinweise
- Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302
Chemie und Industrie
Anwendungen
VerwendenAn anti-inflammatory corticosteroid.
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