Zinkdi(acetat)

Keep in well-closed containers.

Finely divided ... zinc compounds, can be fire and explosion hazard if stored in damp places, sources of spontaneous combustion. /Zinc cmpd/

Environmental considerations: Land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be contained with a flexible impermeable membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.

Environmental considerations: Water spill: Neutralize with agricultural lime (CaO), crushed limestone, or sodium bicarbonate. Add soda ash. Adjust pH to neutral (pH 7). Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates or greater concentration.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Chemical Treatability of Zinc; Concentration Process: Ultrafiltration; Chemical Classification: Metals; Scale of Study: Continuous flow, pilot scale; Type of Wastewater Used: Industrial wastewater; Results of Study: 0.38 ppm effluent concentration. /Zinc/

Chemical Treatability of Zinc; Concentration Process: Miscellaneous sorbents; Chemical Classification: Metals; Scale of Study: Literature review; Type of Wastewater Used: Unknown; Results of Study: Final concentration reduced to 0.1 ppb; SiO2 + CaO slags used. /Zinc/

The proprietary Sulfex process (Permutit Co) has been applied to zinc wastes. The process involves addition of ferrous sulfide, which gradually releases sulfide to precipitate the zinc ... . /Zinc/

For more Disposal Methods (Complete) data for ZINC ACETATE (11 total), please visit the HSDB record page.

If material not on fire and not involved in fire: Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Keep up wind. Avoid breathing vapors or dusts. Wash away any material which may have contacted the body with copious amounts of water or soap and water.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Prevention ... /of metal fume fever/ is a matter of keeping exposure of workers below level of concn currently accepted as satisfactory for working with the metal in industry, preferably by employment of proper local exhaust ventilation to collect fumes at their source. Acceptable respirators are avail commercially but should be used only under suitable conditions. /Zinc/

In all cases where zinc is heated to the point where fume is produced, it is most important to ensure that adequate ventilation is provided. Individual protection is best ensured by education of the worker concerning metal-fume fever & the provision of local exhaust ventilation, or, in some situations by wearing of supplied-air hood or mask.

7.5 [mg/m3]

83 [mg/m3]

500 [mg/m3]

Bu. Mines approved respirator; rubber gloves; chemical goggles (USCG, 1999)

... Recommended appropriate protective equipment including protective eyewear, long-sleeved shirts and long-legged pants, rubber gloves, and boots. /zinc salts/

/NISOH certified respirator/; Rubber gloves; Chemical goggles.

Organic zinc salts such as zinc aspartate, zinc orotate, zinc histidine and zinc acetate protected mice against the lethality of an acute intraperitoneal challenge with ethanol. A similar activity was also provided by salts of cobalt, zirconium, lithium, and magnesium. Organic zinc salts acted synergistically with sulfhydryl compounds in protecting the mice and potentiation between the two categories of agents was seen.

The effect of zinc on mercuric chloride induced lipid peroxidation in the rat kidney was investigated. The rats received zinc acetate (2.0 nmol/kg, po) for 2 days before being given mercuric chloride (15 umol/kg, sc) and were killed 6, 12, and 24 hr after the last injection. Lipid peroxidation occurred in the rat kidney 12 hr after mercury administration, and this mercury induced lipid peroxidation was significantly reduced by zinc pretreatment. A decrease in vitamin C and E contents in the kidney was observed 12 hr after the administration of mercury, and this decrease was prevented by zinc pretreatment. In the kidney of rats pretreated with zinc, the activities of the protective enzymes, glutathione peroxidase and glucose-6-phosphate dehydrogenase, were increased after mercury injection. Non-protein sulfhydryl content (mostly glutathione) also rose markedly.

In comparison with similar experiments in which no zinc acetate was used, the addition of small amounts of zinc acetate to sodium N-methyl-N-dithiocarboxyglucamine produces a significant increase in the amount of cadmium mobilized from the liver and kidneys of mice loaded ip with 10 mg cadmium chloride/kg 2 wk prior to the initiation of treatment. Neither treatment results in the transport of significant amounts of cadmium to the brain. The injection of zinc acetate alone did not produce this effect. Experiments in which zinc acetate in drinking water was administered to cadmium loaded animals showed that the liver and kidney cadmium levels were significantly increased, presumably via zinc mediated processes.

Wistar rats were injected (ip) either with 5 mg cis-diamminedichloro-platinum-II (cis-DDP)/kg, or pretreated with zinc acetate and then injected with cis-DDP. The zinc pretreatment significantly increased the binding of zinc (Zn) and copper (Cu) to both the renal and hepatic metallothioneins, but the proportion of cytosolic platinum associated with metallothioneins in the kidney tissue slightly reduced, and that in the liver showed no difference in comparison to rats treated with cis-diamminedichloro-platinum-II only. The results indicate that an increased cis-diamminedichloro-platinum-II biosynthesis the zinc pretreatment may not correspondingly increase the binding of intracellular Pt to cis-diamminedichloro-platinum-II. In the zinc acetate pretreated rats, the renal tissue and subellular Pt levels were significantly lower (p less than 0.01) than those in untreated rats, although the liver levels showed practically no difference.

For more Interactions (Complete) data for ZINC ACETATE (9 total), please visit the HSDB record page.

TLm Pimephales promelas (fathead minnow) 0.88 ppm/96 hr (soft water) /Conditions of bioassay not specified/

LC50 Eisenia fetida (Earthworm, adult) contact on filter paper 13 ug/sq cm/48 hr (95% confidecne interval: 10-16 ug/sq cm)

LC50 Oncorhynchus mykiss (Rainbow trout) 0.55 mg/L/96 hr; flow through

LC50 Oryzias latipes (Medaka, killfish) 37 mg/L/24 hr; static, 10 °C

For more Ecotoxicity Values (Complete) data for ZINC ACETATE (13 total), please visit the HSDB record page.

Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org

Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49)

Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49)

The assessment of zinc exposure can be accomplished through measurement of zinc. The presence of excess zinc ... can indicate high exposure to zinc; however, no information was found in the literature regarding the accuracy of these levels in predicting possible health effects. Blood Reference Ranges: Normal - average level 1200 ug/dl; Exposed - not established; Toxic - not established. Serum or Plasma Reference Ranges: Normal - average levels 100 ug/dl; Exposed - not established; Toxic - not established. Urine Reference Ranges: Normal - average levels 0.5 mg/g creatinine or 150 to 1200 ug/24 hours; Exposed - urinary concentrations of 600 to 700 ug/l were found in workers exposed to zinc oxide at levels of 3 to 5 mg/cu m; Toxic - greater than 1200 ug/24 hours has been indicated as a toxic urinary level of zinc; however no information was located relating to the severity of symptoms seen with high urinary zinc levels. /Zinc/

Respiratory Symptom Questionnaires: Questionnaires have been published by the American Thoracic Society and the British Medical Research Council. These questionnaires have been found to be useful in identification of people with chronic bronchitis, however certain pulmonary function tests such as FEV1 have been found to be better predictors of chronic airflow obstruction. /Zinc/

Chest Radiography: This test is widely used for assessing pulmonary disease. Chest radiographs have been found to be useful for detection of early lung cancer in asymptomatic people, especially for detection of peripheral tumors such as adenocarcinomas. However, even though OSHA mandates this test for exposure to some toxicants such as asbestos, there are conflicting views on its efficacy in detection of pulmonary disease. /Zinc/

Pulmonary Function Tests: The tests that have been found to be practical for population monitoring include: Spirometry and expiratory flow-volume curves; Determination of lung volumes; Diffusing capacity for carbon monoxide; Single-breath nitrogen washout; Inhalation challenge tests; Serial measurements of peak expiratory flow; Exercise testing. /Zinc/

For more Medical Surveillance (Complete) data for ZINC ACETATE (8 total), please visit the HSDB record page.

/HUMAN EXPOSURE STUDIES/ Researchers/ exposed groups of eight healthy women to 0, 15, 50, or 100 mg supplemental zinc as zinc acetate daily for 60 days (approximately 0, 0.25, 0.83, or 1.7 mg supplemental Zn/kg-day, assuming a reference female body weight of 60 kg) and evaluated effects on serum zinc and cholesterol levels. Zinc exposure resulted in significant, dose-related increases in serum zinc. In the highest exposure group only, plasma HDL-cholesterol was significantly reduced at 4 weeks of exposure, but not at any other timepoint examined. A direct correlation between dietary zinc and whole-blood copper was observed in treated subjects. The study authors noted that in the 50 and 100 mg groups, some bloating, nausea, and abdominal cramps were noted unless the supplement was taken with a large glass of water at mealtime.

/SIGNS AND SYMPTOMS/ ... Metal fume fever results from inhalation of fumes of zinc oxide produced when zinc is heated to high temperatures, such as during welding, metal cutting, or smelting zinc alloys. Victims complain of nausea and vomiting, chills and fever, muscular aches and pains, and weakness.

/LABORATORY ANIMALS: Acute Exposure/ The dermal irritancy of six zinc compounds was examined in three animal models, In open patch tests involving five daily applications, zinc chloride (1% aqueous solution) was severely irritant in rabbit, guinea-pig and mouse tests, inducing epidermal hyperplasia and ulceration; aqueous zinc acetate (20%) was slightly less irritant ... Epidermal irritancy in these studies is related to the interaction of zinc ion with epidermal keratin. The compounds studied were not consistently bacteriostatic in the three species tested.

/LABORATORY ANIMALS: Acute Exposure/ Rats were treated with zinc acetate for four days. The zinc doses were 5 mg Zn/kg and 10 mg Zn/kg body weight respectively. Two groups of the zinc acetate-treated rats were later challenged with a single dose of CCl4 (1.5 mL/kg body weight). Compared to control animals, the plasma of rats treated with CCl4 showed hyperbilirubinemia, hypoglycemia, hypercreatinemia and hypoproteinemia. When the animals were however supplemented with zinc in form of zinc acetate before being dosed with CCl4, the 5 mg Zn/kg body weight of zinc acetate reversed the hypoproteinemia induced by CCl4, whereas the 10 mg Zn/kg body weight of zinc acetate reversed the hypoglycemia, hyperbilirubinemia and hypercreatinemia induced by CCl4. The 10 mg Zn/kg body weight of zinc acetate is more consistent in protecting against CCl4 hepatotoxicity. The possible mechanisms of protection are highlighted.

/LABORATORY ANIMALS: Acute Exposure/ A study was conducted to determine whether divalent metal salts act antagonistically on nickel induced natural killer cell suppression. CBA/J mice were treated with nickel chloride, and/or zinc acetate. In mice injected with nickel chloride at doses of 9, 18, and 36 ug/g, significant suppression of natural killer activity was observed. The injection of nickel alone or in combination with zinc or calcium slightly reduced natural killer activity.

/LABORATORY ANIMALS: Acute Exposure/ Large doses produced violent vomiting, purgation, and abdominal pain and collapse. Wistar rats received 1.0 and 3.0 g/kg bw /of zinc acetate/. The treatment decreased hematocrit, caused an increase in erythrocyte count, and reduction in the percentage of neutrophils and monocytes.

For more Non-Human Toxicity Excerpts (Complete) data for ZINC ACETATE (20 total), please visit the HSDB record page.

Zinc acetate is an indirect food additive for use only as a component of adhesives.

Trace minerals added to animal feeds as nutritional dietary supplements are generally recognized as safe when added at levels consistent with good feeding practice. Zinc acetate is included on this list.

The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl zinc acetate, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.

Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: zinc acetate is included in skin protectant drug products (wound healing claims only).

Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: zinc acetate is included in diaper rash products.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1,000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Zinc acetate is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.

Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Zinc and compounds/

(AZ) ARIZONA 5000 ug/l /Zinc/

(MN) MINNESOTA 2000 ug/l /Zinc/

EPA 5000 ug/l /Zinc/

EPA 2000 ug/l /Zinc, Lifetime health advisory/

CIR ingredient: Zinc Acetate

Used as a wood preservative, mordant in dyeing, antiseptic, feed additive, cross-linking agent for polymers, catalyst, waterproofing agent, therapeutic styptic and astringent, and topical fungicide; Also used to make glazes for porcelain, to treat Wilson's disease, in dental cement for temporary fillings, in tobacco smoke filters, in adhesives for food contact, and as a reagent in testing for albumin, tannin, urobilin, phosphate, and blood; [HSDB] Used to make other zinc compounds; [CAMEO]

Working with Glues and Adhesives [Category: Other]

Preserving wood; as mordant in dyeing; manutactures glazes for painting on porcelain; as a reagent in testing for albumin, tannin, urobilin, phosphate, blood.

Feed additive; cross-linking agent for polymers

Antihistamines were separated by TLC on metal salt-impregnated silica gel plates with ethanol/DMF/ammonium hydroxide as developing solvent and visualization with Dragendorff reagent. Of the metal salts used to impregnate the TLC plates, zinc acetate (1%) gave the best results.

2023: 50,000 - <250,000 lb

(1985) 408X10+3 lb

(1986) >500 thousand-1 million pounds

(1990) >500 thousand-1 million pounds

(1994) >1 million-10 million pounds

For more U.S. Production (Complete) data for ZINC ACETATE (6 total), please visit the HSDB record page.

(2001) 1410 thousand metric tons zinc. /Apparent, all forms/

(2002) 1420 thousand metric tons zinc. /Apparent, all forms/

(2003) 1340 thousand metric tons zinc. /Apparent, all forms/

(2004) 1400 thousand metric tons zinc. /Apparent, all forms/

(2005) 1370 thousand metric tons zinc. /Apparent, all forms/

... Anhydrous salt from zinc nitrate and acetic anhydride.

Action of acetic acid on zinc oxide

REAGENT, 99%; COMMERCIAL, 98.4%

USP, reagent, & technical grades /Dihydrate/

ACS, USP, technical, crystal grades; liquid grade, high purity, ready to use; crystal & anhydrous crystal form, technical grade

GALZIN, Zinc Acetate Capsules (25 mg zinc content) are #1 capsules with aqua blue opaque cap and body, imprinted "93-215." Packaged in bottles of 250 (NDC 57844-215-52). GALZIN, Zinc Acetate Capsules (50 mg zinc content) are #1 capsules with orange opaque cap and body, imprinted "93-208." Packaged in bottles of 250 (NDC 57844-208-52).

Food additives

Cosmetics -> Antimicrobial

All Other Chemical Product and Preparation Manufacturing

Acetic acid, zinc salt (2:1): ACTIVE