Grundinformationen
- CAS
562-10-7- Standard-SMILES
CN(C)CCOC(C)(c1ccccc1)c1ccccn1.O=C(O)CCC(=O)O- InChIKey
KBAUFVUYFNWQFM-UHFFFAOYSA-N- Summenformel
- C17H22N2O.C4H6O4
- Durchschnittliche Molmasse
- 388,5 g/mol
- Monoisotopische Masse
- 388,199822
Überblick
Doxylamine succinate appears as white or creamy white powder. pH (1% aqueous solution) between 4.9 and 5.1. (NTP, 1992)
Namen und Bezeichner
- Bevorzugter Name
- Donormil
- IUPAC
- butanedioic acid;N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine
- Lokaler Name
- Doxylaminhydrogensuccinat
- Englischer Name
- Doxylamine succinate
- Summenformel
- C21H28N2O5
- Molmasse
- 388.46
Namen und Synonyme
Doxylamine succinate562-10-7DecaprynGittalunUnisomHoggar NDoxy-sleep-aidA-H InjectionDonormilMereprineSedaplusDoxylamine succinate (1:1)
Weitere Namen anzeigen
hoggarnalsadormDoxylaMineSuccinatDecapryn succinate
AlsodormDonormylDormidinaMeraprinaDecapryn succinate (1:1)Topcare sleep aidDTXSID7020552V9BI9B5YI2
Datenbank-Bezeichner
- CAS
562-10-7- PubChem CID
- 11224
- DTXSID
DTXSID7020552- ChEMBL
CHEMBL1200392- ChEBI
CHEBI:82461- UNII
- V9BI9B5YI2
- EC Number
- 209-228-7
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 100 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 7
- Frei drehbare Bindungen
- 9
- Schwere Atome
- 28
- Formalladung
- 0
- Komplexität
- 369
Experimentelle und physikochemische Eigenschaften
Solubility
greater than or equal to 100 mg/mL at 72 °F (NTP, 1992)
>58.3 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal DrugsFDA approved animal drugs -> Active ingredient
Melting Point217 to 226 °F (NTP, 1992)
Physical DescriptionDoxylamine succinate appears as white or creamy white powder. pH (1% aqueous solution) between 4.9 and 5.1. (NTP, 1992)
Collision Cross Section162.6 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physikochemische Eigenschaften
- Schmelzpunkt
- 95 · 95-98C
- Flammpunkt
- 9 ℃ · 9℃
- storage temp.
- 2 · 2-8°C
- Löslichkeit
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 1.1% (1 of 88) of reports.
Warning
H302 (98.9%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 88 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Other Safety InformationIMAP assessments - Butanedioic acid, compound with N,N-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]ethanamine (1:1): Environment tier I assessment
Fire HazardsFlash point data for this chemical are not available. It is probably combustible. (NTP, 1992)
Health HazardsSYMPTOMS: Symptoms of exposure to this compound may include drowsiness, excitability, nervousness, dizziness and sleeplessness. (NTP, 1992)
Reactive GroupAcids, Carboxylic
Air and Water ReactionsWater soluble.
Hazard Classes and CategoriesAcute Tox. 4 (98.9%)
Sicherheit und Schutzausrüstung
Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
Chemie und Industrie
Pharmakologische Informationen
FDA Pharmacological Classification
DOXYLAMINE SUCCINATE
Antihistamine [EPC]; Histamine Receptor Antagonists [MoA]
NIGHTTIME SLEEP AID
Antihistamine [EPC]; Histamine Receptor Antagonists [MoA]; Histamine H1 Receptor Antagonists [MoA]; Histamine-1 Receptor Antagonist [EPC]
SLEEP AID
Histamine H1 Receptor Antagonists [MoA]; Histamine-1 Receptor Antagonist [EPC]
MeSH Pharmacological Classification
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
Anwendungen
VerwendenDoxylamine succinate salt has been used as a therapeutic drug to check developmental toxicity.
Anbieter100 Anbieter
国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
上海沛灵生物科技有限公司13127581762 13127581762 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Shandong chuangyingchemical Co., Ltd.18853181302 · [email protected]
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