Semicarbazide hydrochloride｜Huagongshe

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HCID 11236Erstellt: 27. Oktober 2026

Semicarbazide hydrochloride

https://huagongshe.com/de/chemical/11236

Molekülstruktur von Semicarbazide hydrochloride

Identifikatoren & physikalische Daten

CAS No.	18396-65-1
Summenformel	CH5N3O.ClH
Durchschnittliche Molmasse	111,53 g/mol
Monoisotopische Masse	111,01993949 g/mol
SMILES	Cl.NNC(N)=O
InChIKey	XHQYBDSXTDXSHY-UHFFFAOYSA-N
PubChem CID	11236
ChEMBL	CHEMBL1256355
ChEBI	CHEBI:82532
EC No.	209-247-0
DTXSID	DTXSID4020244

Chemische & physikalische Eigenschaften

Polarare Oberfläche (TPSA)	81,1
H-Brücken-Donoren	4
H-Brücken-Akzeptoren	2
Frei drehbare Bindungen	0
Schwere Atome	6
Formalladung	0
Komplexität	42,2
Stoffklassen	Nitrogen Compounds -> Other Nitrogen Compounds
LogP (Verteilungskoeffizient)	log Kow = -2.75
Color/Form	Prisms from dilute alcoholWhite crystals
Löslichkeit	Very soluble (NTP, 1992)Freely sol in water with acid reactionvery slightly sol in hot alcoholInsol in anhyd etherInsoluble in absolute alcoholIn water, 1X10+6 mg/L at 25 °C /Estimated/9.2 [ug/mL] (The mean of the results at pH 7.4)
Siedepunkt	347 to 365 °F at 760 mmHg DECOMPOSES (NTP, 1992)
Decomposition	When heated to decomposition it emits very toxic fumes of /nitrogen oxides and hydrogen chloride/.
Schmelzpunkt	342 to 347 °F decomposes at 347-365 °F (EPA, 1998)175-185 °C /decomposes/MP: 96 °C /Base/
Dampfdruck	0.13 [mmHg]0.13 mm Hg at 25 °C /Estimated/
Henry-Konstante	Henry's Law constant = 1.5X10-12 atm-cu m/mol at 25 °C /Estimated/
Physical Description	Snow white crystals. Used as a reagent for ketones and aldehydes with which it affords crystalline compounds having characteristic melting points. (EPA, 1998)White solid[Hawley] White powder[MSDSonline]
Dissociation Constants	pKa = 10.8
Other Experimental Properties	Ammonolysis with liquid NH3 gives 95% yield of free baseHydroxyl radical reaction rate constant = 2X10-12 cu cm/molec-sec at 25 °C /Estimated/

Sicherheit & Vorschriften

GHS-Einstufung	This chemical does not meet GHS hazard criteria for 2.2% (2 of 93) of reports.DangerH301 (96.8%): Toxic if swallowed [Danger Acute toxicity, oral]P203, P260, P264, P264+P265, P270, P280, P301+P316, P302+P352, P305+P351+P338, P305+P354+P338, P317, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 93 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Warning
Regulatorische Informationen	Chemical: Hydrazinecarboxamide, monohydrochlorideStatus: Active Update: 08-02-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/29438Semicarbazide hydrochloride: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
DOT-Kennzeichnung	Poison
Brandgefahren	When heated to decomposition, it emits very toxic fumes of nitrogen oxides and hydrogen chloride. (EPA, 1998)
Gesundheitsgefahren	Toxic by ingestion. (EPA, 1998)
Gefahrenübersicht	Toxic by ingestion[Hawley] An irritant[MSDSonline] See Semicarbazide.
Reaktive Gruppe	Amides and Imides
Reactivity Profile	When heated to decomposition, it emits very toxic fumes of nitrogen oxides and hydrogen chloride. [EPA, 1998].
Air and Water Reactions	Water soluble. Acid reaction in water. (NTP, 1992)
CERCLA-Meldepflichtmengen	Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Semicarbazide hydrochloride is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 1,000/10,000 lbs.

Erste Hilfe	Signs and Symptoms of Semicarbazide Hydrochloride Exposure: No information on specific clinical effects of exposure to semicarbazide hydrochloride was found in available references. However, animal data indicate that signs and symptoms of acute exposure to semicarbazide hydrochloride may include loss of coordination, dizziness, tremors, convulsions, and seizures.

Freisetung ohne Brand

(Non-Specific -- Poisonous Solid, n.o.s.) Isolate hazard area. Stay upwindkeep out of low areas. Do not touch spilled material. Absorb small spills with sand or other noncombustible absorbent material and place into containers for later disposal. Take up small, dry spills with clean shovelplace material into clean, dry container and covermove containers from spill area. Dike far ahead of large spills for later disposal. (EPA, 1998)

Entsorgungsverfahren

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.

Personal Protective Equipment (PPE)	For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

Ökotoxizitätswerte	EC50 Xenopus laevis (Clawed toad embryosabnormal growth) 10,800 ug/L/96 hr (95% confidence interval: 9200-12,100)renewalLC50 Xenopus laevis (Clawed toad embryos) ca. 6 g/L/96 hr, (95% confidence interval: 5.3-6.1 g/L)

Lebensmitteluntersuchungswerte	Semicarbazide is present in certain foods packaged in glass jars and bottles in very low quantities (ppb or ug/kg of food) due to migration from the plastic gasket which forms the airtight seal in the metal lid. Amount of up to 25 ppb have been found in baby foods, which give an estimate of intake of around 2 ug/kg bw/day as a worst case for infants /age 4-12 months/. /Semicarbazide/

Non-Human Toxicity Excerpts

/LABORATORY ANIMALS: Acute Exposure/ Administration of 200 mg/kg to acute spinal cats resulted in gradual and complete depression of dorsal root reflex and potential..., also decreased long-latency. Time course of these effects correlated with time course of induced depletion of gamma-aminobutyric acid in spinal cord./LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Fourteen chemicals of varied uses were tested for carcinogenicity by oral administration in male and female Charles River CD rats. ...Semicarbazide hydrochloride /was/ not carcinogenic under the test conditions./LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ ... Admin to 25 male and 25 female 6-wk old Swiss mice for lifetime as 0.0625% solution in drinking water. Average daily intakes...3.3 mg/female and 4.8 mg/male. ... Tumors of vascular origin ... in 9/50 ... females, compared with 5/99 ... controls, and in 3/50 ... males, compared with 6/99 ... controls. ... Including 6 angiosarcomas and 2 angiomas of liver. ... In females, 37 lung tumors occurred in 25/50 ... compared with 31 in 21/99 female controls...no increase in incidence of lung tumors in treated males./LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ ...6-8-wk old female DD mice were fed diet containing 0.1%...for 7 mo. at end of treatment, 8 survivors were killed and examined for lung tumors: 6 mice had total of 8 lung tumors, compared with 1 tumor in 20 controls.For more Non-Human Toxicity Excerpts (Complete) data for SEMICARBAZIDE HYDROCHLORIDE (12 total), please visit the HSDB record page.

Populations at Special Risk	Biological half-lives were significantly different among the three acetylation phenotypes (analysis of variance, P < 0.05): 3.94+/-1.70 hours for slow acetylators, 2.25+/-0.37 hours for intermediate acetylators, and 1.86+/-0.67 hours for rapid acetylators. /Hydrazine/

Evidence for Carcinogenicity	No data are available in humans. Limited evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.

Antidote and Emergency Treatment

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry, sterile dressings after decontamination ... . /Hydrazine and Related Compounds/Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam ... . Monitor for signs of hypoglycemia (decreased level of consciousness, tachycardia, pallor, dilated pupils, diaphoresis, and/or a dextrose strip or glucometer reading less than 50 mg/dl) and administer 50% dextrose if necessary. Draw blood sample before administration ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Hydrazine and Related Compounds/